Method for improved utilization of the production potential of transgenic plants

ABSTRACT

The invention relates to a method for improving the utilization of the production potential of transgenic plants by treating the plant with an effective amount of at least one compound of the formula (I) as described herein.

The invention relates to a method for improving the utilization of the production potential of transgenic plants and for controlling pests such as insects and/or nematodes.

In recent years, there has been a marked increase in the proportion of transgenic plants in agriculture.

Transgenic plants are employed mainly to utilize the production potential of respective plant varieties in the most favourable manner, at the lowest possible input of production means. The aim of the genetic modification of the plants is in particular the generation of resistance in the plants to certain pests or harmful organisms or else herbicides and also to abiotic stress (for example drought, heat or elevated salt levels). It is also possible to modify a plant genetically to increase certain quality or product features, such as, for example, the content of selected vitamins or oils, or to improve certain fibre properties.

Herbicide resistance or tolerance can be achieved, for example, by incorporating genes into the useful plant for expressing enzymes to detoxify certain herbicides, so that a relatively unimpeded growth of these plants is possible even in the presence of these herbicides for controlling broad-leaved weeds and weed grasses. Examples which may be mentioned are cotton varieties or maize varieties which tolerate the herbicidally active compound glyphosate (Roundup®), (Roundup Ready®, Monsanto) or the herbicides glufosinate or oxynil.

There has also been the development of useful plants comprising two or more genetic modifications (“stacked transgenic plants” or multiply transgenic crops). Thus, for example, Monsanto has developed multiply transgenic maize varieties which are resistant to the European corn borer (Ostrinia nubilalis) and the Western corn rootworm (Diabrotica virgifera). Also known are maize and cotton crops which are both resistant to the Western corn rootworm and the cotton bollworm and tolerant to the herbicide Roundup®.

It has now been found that the utilization of the production potential of transgenic useful plants can be improved even more by treating the plants with one or more compounds of the formula (I) defined below. Here, the term “treatment” includes all measures resulting in a contact between these active compounds and at least one plant part. “Plant parts” are to be understood as meaning all above-ground and below-ground parts and organs of plants, such as shoot, leaf, flower and root, by way of example leaves, needles, stalks, stems, flowers, fruit bodies, fruits and seed, and also roots, tubers and rhizomes. The plant parts also include harvested material and also vegetative and generative propagation material, for example cuttings, tubers, rhizomes, slips and seed.

SUMMARY OF THE INVENTION

One aspect refers to a method for improving the utilization of the production potential of a transgenic plant and/or for controlling/combating/treating pests, characterized in that the plant is treated with an effective amount of at least one compound of the formula (I)

-   -   wherein     -   A represents individually halogen, cyano, nitro, hydroxyl,         amino, C₁-C₈ alkyl group, substituted C₁-C₈ alkyl group having         at least one substituent elected from the group consisting of         halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group,         C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group, C₁-C₃ alkylthio         group, halo C₁-C₃ alkylthio group, C₁-C₃ alkylsulfinyl group,         halo C₁-C₃ alkylsulfinyl group, C₁-C₃ alkylsulfonyl group, halo         C₁-C₃ alkylsulfonyl group and C₁-C₃ alkylthio, C₁-C₃ alkyl         group; further, an arbitrary saturated carbon atom in said         optionally substituted C₁-C₈ alkyl group;     -   n represents 0, 1, 2, 3 or 4, preferably 0, 1 or 2;     -   R₁ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈         haloalkyl;     -   R₂ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈         haloalkyl;     -   R₃ represents O or S;     -   R₄ represents O or S;     -   Y represents individually hydrogen, halogen, cyano, nitro, C₁-C₆         alkyl group, halo C₁-C₆ alkyl group, C₂-C₆ alkenyl group, halo         C₂-C₆ alkenyl group, C₂-C₆ alkynyl group, halo C₂-C₆ alkynyl         group, C₃-C₆ cycloalkyl group, halo C₃-C₆ cycloalkyl group,         C₁-C₆ alkoxy group, halo C₁-C₆ alkoxy group, C₁-C₆ alkylthio         group, halo C₁-C₆ alkylthio group, C₁-C₆ alkylsulfinyl group,         halo C₁-C₆ alkylsulfinyl group, C₁-C₆ alkylsulfonyl group, or         halo C₁-C₆ alkylsulfonyl group;     -   m represents 0, 1, 2, 3, or 4;     -   X represents a C₁-C₈ alkyl group or a substituted C₁-C₈ alkyl         group having at least one substituent selected from the group         consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃         alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group

One preferred embodiment refers to the method described above, characterized in that the compound of the formula (I) is formula (I-1):

-   -   wherein     -   Hal represents F, Cl, I or Br; and     -   X′ represents C₁-C₆ alkyl or substituted C₁-C₆ alkyl having at         least one substituent selected from the group consisting of         halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group,         preferably a C₁-C₆ cyanoalkyl;     -   A′ represents C₁-C₃ alkyl, C₁-C₃ haloalkyl, halogen, preferably         methyl, halomethyl, ethyl or haloethyl, more preferably methyl         or ethyl;     -   n represents 0, 1, 2, 3 or 4, preferably 0, 1 or 2, more         preferably 1.

One preferred embodiment refers to the method described above, characterized in that the compound of the formula (I) is selected from the group consisting of compound (I-2), (I-3), (I-4) or (I-5):

One preferred embodiment refers to the method described above, characterized in that the compound of the formula (I) is compound (I-5).

Further preferred embodiments refer to the method described above, characterized in that the plant has at least one genetically modified structure or a tolerance according to Table A or Table B or Table C.

Further preferred embodiments refer to the method described above, characterized in that the transgenic plant contains at least one cry-gene or a cry-gene fragment coding for a Bt toxin.

One preferred embodiment refers to the method described above, characterized in that the transgenic plant is a vegetable plant, maize plant, soya bean plant, cotton plant, tobacco plant, rice plant, sugar beet plant, oilseed rape plant or potato plant.

One preferred embodiment refers to the method described above, characterized in that the use form of the compound of the formula (I) is present in a mixture with at least one mixing partner.

One preferred embodiment refers to the method described above, characterized in that the Bt toxin of a Bt-plant is encoded by a bt-gene or fragment thereof comprising event MON87701.

Another aspect refers to a synergistic composition comprising a Bt toxin and a compound of formula (I) as described above.

One preferred embodiment refers to said synergistic composition, characterized in that the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the group consisting of cry1, cry2, cry3, cry5 and cry9.

One preferred embodiment refers to said synergistic composition, characterized in that the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the group consisting of especially preferred are cry1Ab, cry1Ac, cry3A, cry3B and cry9C.

One preferred embodiment refers to said synergistic composition, characterized in that the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the subgroup cry1A, preferably cry1Aa, cry1Ab, cry1Ac or a hybrid thereof (e.g., a hybrid of cry1Ac and cry1Ab).

One preferred embodiment refers to said synergistic composition, characterized in that the Bt toxin is encoded by a bt-gene or fragment thereof comprising event MON87701.

A Bt plant, preferably a Bt-soybean plant comprising event MON87701 or a Bt-soybean plant comprising event MON87701 and MON89788, characterized in that at least 0.00001 g of a compound of formula (I) is attached to it.

The preferred embodiments may be combined as long as such a combination would not contravene existing natural laws.

DETAILED DESCRIPTION

Compounds of the formula (I)

wherein A represents individually halogen, cyano, nitro, hydroxyl, amino, C₁-C₈ alkyl group, substituted C₁-C₈ alkyl group having at least one substituent elected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group, C₁-C₃ alkylthio group, halo C₁-C₃ alkylthio group, C₁-C₃ alkylsulfinyl group, halo C₁-C₃ alkylsulfinyl group, C₁-C₃ alkylsulfonyl group, halo C₁-C₃ alkylsulfonyl group and C₁-C₃ alkylthio, C₁-C₃ alkyl group; further, an arbitrary saturated carbon atom in said optionally substituted C₁-C₈ alkyl group; n represents 0, 1, 2, 3 or 4, preferably 0, 1 or 2; R₁ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₂ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₃ represents O or S; R₄ represents O or S; Y represents individually hydrogen, halogen, cyano, nitro, C₁-C₆ alkyl group, halo C₁-C₆ alkyl group, C₂-C₆ alkenyl group, halo C₂-C₆ alkenyl group, C₂-C₆ alkynyl group, halo C₂-C₆ alkynyl group, C₃-C₆ cycloalkyl group, halo C₃-C₆ cycloalkyl group, C₁-C₆ alkoxy group, halo C₁-C₆ alkoxy group, C₁-C₆ alkylthio group, halo C₁-C₆ alkylthio group, C₁-C₆ alkylsulfinyl group, halo C₁-C₆ alkylsulfinyl group, C₁-C₆ alkylsulfonyl group, or halo C₁-C₆ alkylsulfonyl group; m represents 0, 1, 2, 3, or 4; X represents a C₁-C₈ alkyl group or a substituted C₁-C₈ alkyl group having at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group and their insecticidal action are known from the prior art (see, e.g., EP 0 919 542, W0 2004/018410, W0 2010/012442 or WO 2012/034472).

From these documents, the person skilled in the art will be familiar with processes for preparing and methods for using compounds of the formula (I) and with the action of compounds of the formula (I).

Preferred sub-groups and compounds of formula (I) mentioned above are listed below.

In a preferred embodiment of the present invention, the compounds of the general formula (I) is represented by compounds of formula (I-1):

wherein Hal represents F, Cl, I or Br; and X′ represents C₁-C₆ alkyl or substituted C₁-C₆ alkyl having at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, preferably a C₁-C₆ cyanoalkyl; A′ represents C₁-C₃ alkyl, C₁-C₃ haloalkyl, halogen, preferably methyl, halomethyl, ethyl or haloethyl, more preferably methyl or ethyl; n represents 0, 1, 2, 3 or 4, preferably 0, 1 or 2, more preferably 1.

In a more preferred embodiment of the present invention, a composition comprises at least one compound of the general formula (I) selected from the group consisting of compound (I-2), (I-3), (I-4) or (I-5):

Even more preferably, a compound of formula (I) is selected from the group consisting of compound (I-2) or compound (I-5).

In one preferred embodiment, the compound of formula (I) is compound (I-5).

According to the invention, “alkyl” represents straight-chain or branched aliphatic hydrocarbons having 1 to 8, preferably 1 to 6, more preferably 1 to 3, carbon atoms. Suitable alkyl groups are, for example, methyl, ethyl, n-propyl, i-propyl, n-, iso-, sec- or tert-butyl, pentyl or hexyl. The alkyl group may be unsubstituted or is substituted by at least one of the substituents mentioned here.

According to the invention, “halogen” or “Hal” represents fluorine, chlorine, bromine or iodine, preferably fluorine, chlorine or bromine.

According to the invention, “haloalkyl” represents alkyl groups having up to 8 carbon atoms in which at least one hydrogen atom has been replaced by a halogen. Suitable haloalkyl groups are, for example, CH₂F, CHF₂, CF₃, CF₂Cl, CFCl₂, CCl₃, CF₂Br, CF₂CF₃, CFHCF₃, CH₂CF₃, CH₂CH₂F, CH₂CHF₂, CFClCF₃, CCl₂CF₃, CF₂CH₃, CF₂CH₂F, CF₂CHF₂, CF₂CF₂Cl, CF₂CF₂Br, CFHCH₃, CFHCHF₂, CHFCF₃, CHFCF₂Cl, CHFCF₂Br, CFClCF₃, CCl₂CF₃, CF₂CF₂CF₃, CH₂CH₂CH₂F, CH₂CHFCH₃, CH₂CF₂CF₃, CF₂CH₂CF₃, CF₂CF₂CH₃, CHFCF₂CF₃, CF₂CHFCF₃, CF₂CF₂CHF₂, CF₂CF₂CH₂F, CF₂CF₂CF₂Cl, CF₂CF₂CF₂Br, 1,2,2,2-tetrafluoro-1-(trifluoromethyl)ethyl, 2,2,2-trifluoro-1-(trifluoromethyl)ethyl, pentafluoroethyl, 1-(difluoromethyl)-1,2,2,2-tetrafluoroethyl, 2-bromo-1,2,2-trifluoro-1-(trifluoromethyl)ethyl, 1-(difluoromethyl)-2,2,2-trifluoroethyl. The haloalkyl group may be unsubstituted or is substituted by at least one of the substituents mentioned here.

“Production potential” as used herein refers to the yield of a transgenic plant under specific conditions. “Improving the utilization of the production potential of transgenic plants” thus refers to an increase of yield under unfavorable environmental conditions such as use of herbicides, drought stress, cold stress, stress induced by insects, nematodes, or fungus etc. compared to the yield of such plants under the same conditions without the use of the compounds of formula (I) as described herein.

The method can also be used for an increased control/an increased treatment of pests such as insects and/or nematodes. Thus, the combination of a transgenic plant such as a Bt-plant and a compound of formula (I) can show better treatment/control/combating of insects and/or nematodes compared to the expected effect.

According to the method proposed according to the invention, transgenic plants, in particular useful plants, are treated with compounds of the formula (I) to increase agricultural productivity and/or to control and/or to combat pests, especially nematodes and insects. Preferably, the invention refers to a method for combating pests by treating transgenic plants, preferably insect-resistant transgenic plant such as Bt-plants or Vip-plants with a compound of formula (I), preferably with a compound of formula (I-5).

For the purpose of the invention, genetically modified organisms (GMOs), e.g. plants or seeds, are genetically modified plants (or transgenic plants) are plants of which a heterologous gene has been stably integrated into genome. The expression “heterologous gene” essentially means a gene which is provided or assembled outside the plant and when introduced in the nuclear, chloroplastic or mitochondrial genome gives the transformed plant new or improved agronomic or other properties by expressing a protein or polypeptide of interest or by downregulating or silencing other gene(s) which are present in the plant (using for example, antisense technology, cosuppression technology, RNA interference—RNAi—technology or microRNA—miRNA—technology). A heterologous gene that is located in the genome is also called a transgene. A transgene that is defined by its particular location in the plant genome is called a transformation or transgenic event.

Depending on the plant species or plant cultivars, their location and growth conditions (soils, climate, vegetation period, diet), the treatment according to the invention may also result in superadditive (“synergistic”) effects. Thus, for example, reduced application rates and/or a widening of the activity spectrum and/or an increase in the activity of the active compounds and compositions which can be used according to the invention, better plant growth, increased tolerance to high or low temperatures, increased tolerance to drought or to water or soil salt content, increased flowering performance, easier harvesting, accelerated maturation, higher harvest yields, bigger fruits, larger plant height, greener leaf color, earlier flowering, higher quality and/or a higher nutritional value of the harvested products, higher sugar concentration within the fruits, better storage stability, increased combating of pests, especially nematodes and insects and/or processability of the harvested products are possible, which exceed the effects which were actually to be expected.

At certain application rates, the active compound combinations according to the invention may also have a strengthening effect in plants. Accordingly, they are also suitable for mobilizing the defense system of the plant against attack by unwanted microorganisms. This may, if appropriate, be one of the reasons of the enhanced activity of the combinations according to the invention, for example against fungi. Plant-strengthening (resistance-inducing) substances are to be understood as meaning, in the present context, those substances or combinations of substances which are capable of stimulating the defense system of plants in such a way that, when subsequently inoculated with unwanted microorganisms, the treated plants display a substantial degree of resistance to these microorganisms. In the present case, unwanted microorganisms are to be understood as meaning phytopathogenic fungi, bacteria and viruses. Thus, the substances according to the invention can be employed for protecting plants against attack by the abovementioned pathogens within a certain period of time after the treatment. The period of time within which protection is effected generally extends from 1 to 10 days, preferably 1 to 7 days, after the treatment of the plants with the active compounds.

Plants and plant cultivars which are preferably to be treated according to the invention include all plants which have genetic modified material which impart particularly advantageous, useful traits to these plants (whether obtained by breeding and/or biotechnological means).

Plants and plant cultivars which are also preferably to be treated according to the invention are resistant against one or more biotic stresses, i.e. said plants show a better defense against animal and microbial pests, such as against nematodes, insects, mites, phytopathogenic fungi, bacteria, viruses and/or viroids.

Examples of nematode or insect resistant plants are described in e.g. U.S. patent application Ser. Nos. 11/765,491, 11/765,494, 10/926,819, 10/782,020, 12/032,479, 10/783,417, 10/782,096, 11/657,964, 12/192,904, 11/396,808, 12/166,253, 12/166,239, 12/166,124, 12/166,209, 11/762,886, 12/364,335, 11/763,947, 12/252,453, 12/209,354, 12/491,396, 12/497,221, 12/644,632, 12/646,004, 12/701,058, 12/718,059, 12/721,595, 12/638,591, and in WO 11/002992, WO 11/014749, WO 11/103247, WO 11/103248, WO 12/135436, WO 12/135501.

Examples of plants resistant to other types of pathogens are described in e.g. WO13/050410.

Plants and plant cultivars which may also be treated according to the invention are those plants which are resistant to one or more abiotic stresses. Abiotic stress conditions may include, for example, drought, cold temperature exposure, heat exposure, osmotic stress, flooding, increased soil salinity, increased mineral exposure, ozone exposure, high light exposure, limited availability of nitrogen nutrients, limited availability of phosphorus nutrients, shade avoidance.

Plants and plant cultivars which may also be treated according to the invention, are those plants characterized by enhanced yield characteristics. Increased yield in said plants can be the result of, for example, improved plant physiology, growth and development, such as water use efficiency, water retention efficiency, improved nitrogen use, enhanced carbon assimilation, improved photosynthesis, increased germination efficiency, improved combating of insects and accelerated maturation. Yield can furthermore be affected by improved plant architecture (under stress and non-stress conditions), including but not limited to, early flowering, flowering control for hybrid seed production, seedling vigor, plant size, internode number and distance, root growth, seed size, fruit size, pod size, pod or ear number, seed number per pod or ear, seed mass, enhanced seed filling, reduced seed dispersal, reduced pod dehiscence and lodging resistance. Further yield traits include seed composition, such as carbohydrate content, protein content, oil content and composition, nutritional value, reduction in anti-nutritional compounds, improved processability and better storage stability.

Examples of plants with the above-mentioned traits are non-exhaustively listed in Table A.

TABLE A Event Company Description Crop Patent Ref ASR36 Scotts Glyphosate tolerance derived by inserting a Agrostis US 2006- 8 Seeds modified 5-enolpyruvylshikimate-3- stolonifera 162007 phosphate synthase (EPSPS) encoding gene Creeping from Agrobacterium tumefaciens, parent Bentgrass line B99061 GT200 Monsanto Glyphosate herbicide tolerant canola Brassica Company produced by inserting genes encoding the napus enzymes 5-enolypyruvylshikimate-3- (Argentine phosphate synthase (EPSPS) from the CP4 Canola) strain of Agrobacterium tumefaciens and glyphosate oxidase from Ochrobactrum anthropi. B, Da, Zeneca Delayed softening tomatoes produced by Lycopersicon F Seeds inserting a truncated version of the esculentum polygalacturonase (PG) encoding gene in the (Tomato) sense or anti-sense orientation in order to reduce expression of the endogenous PG gene, and thus reduce pectin degradation. FLAVR Calgene Delayed softening tomatoes produced by Lycopersicon SAVR Inc. inserting an additional copy of the esculentum polygalacturonase (PG) encoding gene in the (Tomato) anti-sense orientation in order to reduce expression of the endogenous PG gene and thus reduce pectin degradation. J101, Monsanto Glyphosate herbicide tolerant alfalfa Medicago J163 Company (lucerne) produced by inserting a gene sativa (Alfalfa) and Forage encoding the enzyme 5- Genetics enolypyruvylshikimate-3-phosphate International synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. C/F/93/ Societe Tolerance to the herbicides bromoxynil and Nicotiana 08-02 National ioxynil by incorporation of the nitrilase gene tabacum d'Exploitation from Klebsiella pneumoniae. L. (Tobacco) des Tabacs et Allumettes Vector Vector Reduced nicotine content through Nicotiana 21-41 Tobacco introduction of a second copy of the tobacco tabacum Inc. quinolinic acid phosphoribosyltransferase L. (Tobacco) (QTPase) in the antisense orientation. The NPTII encoding gene from E. coli was introduced as a selectable marker to identify transformants. CL121, BASF Inc. Tolerance to the imidazolinone herbicide, Oryza CL141, imazethapyr, induced by chemical sativa (Rice) CFX51 mutagenesis of the acetolactate synthase (ALS) enzyme using ethyl methanesulfonate (EMS). GAT- AVENTIS Glufosinate tolerance; WO 01/83818 Oryza WO 01/83818 OS2 CROPSCIENCE sativa (Rice) NV GAT- BAYER Glufosinate tolerance; US 2008-289060 Oryza US 2008- OS3 BIOSCIENCE sativa (Rice) 289060 NV [BE] IMINT BASF Inc. Tolerance to imidazolinone herbicides Oryza A-1, induced by chemical mutagenesis of the sativa (Rice) IMINT acetolactate synthase (ALS) enzyme using A-4 sodium azide. LLRIC Aventis Glufosinate ammonium herbicide tolerant Oryza E06, CropSience rice produced by inserting a modified sativa (Rice) LLRIC phosphinothricin acetyltransferase (PAT) E62 encoding gene from the soil bacterium Streptomyces hygroscopicus). GT73, Monsanto Glyphosate herbicide tolerant canola Brassica RT73 Company produced by inserting genes encoding the napus enzymes 5-enolypyruvylshikimate-3- (Argentine phosphate synthase (EPSPS) from the CP4 Canola) strain of Agrobacterium tumefaciens and glyphosate oxidase from Ochrobactrum anthropi. LLRIC Bayer Glufosinate ammonium herbicide tolerant Oryza E601 CropScience rice produced by inserting a modified sativa (Rice) (Aventis phosphinothricin acetyltransferase (PAT) CropScience encoding gene from the soil bacterium (AgrEvo)) Streptomyces hygroscopicus). PE-7 MAHARA Insect resistance (Cry1Ac); WO Oryza WO SHTRA 2008/114282 sativa (Rice) 2008/114282 HYBRID SEEDS COMPA PWC16 BASF Inc. Tolerance to the imidazolinone herbicide, Oryza imazethapyr, induced by chemical sativa (Rice) mutagenesis of the acetolactate synthase (ALS) enzyme using ethyl methanesulfonate (EMS). TT51 ZHEJIANG Insect resistance (Cry1Ab/Cry1Ac); Oryza CN1840655 UNIVERSITY CN1840655 sativa (Rice) C5 United Plum pox virus (PPV) resistant plum tree Prunus States produced through Agrobacterium-mediated domestica Department transformation with a coat protein (CP) gene (Plum) of from the virus. Agriculture Agricultural Research Service ATBT0 Monsanto Colorado potato beetle resistant potatoes Solanum 4-6, Company produced by inserting the cry3A gene from tuberosum ATBT0 Bacillus thuringiensis (subsp. Tenebrionis). L. (Potato) 4-27, ATBT0 4-30, ATBT0 4-31, ATBT0 4-36, SPBT0 2-5, SPBT0 2-7 BT6, Monsanto Colorado potato beetle resistant potatoes Solanum BT10, Company produced by inserting the cry3A gene from tuberosum BT12, Bacillus thuringiensis (subsp. Tenebrionis). L. (Potato) BT16, BT17, BT18, BT23 RBMT Monsanto Colorado potato beetle and potato virus Y Solanum 15-101, Company (PVY) resistant potatoes produced by tuberosum SEMT1 inserting the cry3A gene from Bacillus L. (Potato) 5-02, thuringiensis (subsp. Tenebrionis) and the SEMT1 coat protein encoding gene from PVY. 5-15 RBMT Monsanto Colorado potato beetle and potato leafroll Solanum 21-129, Company virus (PLRV) resistant potatoes produced by tuberosum RBMT inserting the cry3A gene from Bacillus L. (Potato) 21-350, thuringiensis (subsp. Tenebrionis) and the RBMT replicase encoding gene from PLRV. 22-082 HCN10 Aventis Introduction of the PPT-acetyltransferase Brassica CropScience (PAT) encoding gene from Streptomyces napus viridochromogenes, an aerobic soil bacteria. (Argentine PPT normally acts to inhibit glutamine Canola) synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. AP205 BASF Inc. Selection for a mutagenized version of the Triticum CL enzyme acetohydroxyacid synthase (AHAS) aestivum also known as acetolactate synthase (ALS) (AHAS), (Wheat) or acetolactate pyruvate-lyase. AP602 BASF Inc. Selection for a mutagenized version of the Triticum CL enzyme acetohydroxyacid synthase (AHAS) , aestivum also known as acetolactate synthase (ALS) (Wheat) or acetolactate pyruvate-lyase. BW255- BASF Inc. Selection for a mutagenized version of the Triticum 2, enzyme acetohydroxyacid synthase (AHAS), aestivum BW238- also known as acetolactate synthase (ALS) (Wheat) 3 or acetolactate pyruvate-lyase. BW7 BASF Inc. Tolerance to imidazolinone herbicides Triticum induced by chemical mutagenesis of the aestivum acetohydroxyacid synthase (AHAS) gene (Wheat) using sodium azide. Event 1 Syngenta Fusarium resistance (trichothecene 3-O- Triticum CA 2561992 Participations acetyltransferase); CA 2561992 aestivum AG (Wheat) JOPLI Syngenta disease (fungal) resistance (trichothecene 3- Triticum US N1 Participations O-acetyltransferase); US 2008064032 aestivum 2008064032 AG (Wheat) MON7 Monsanto Glyphosate tolerant wheat variety produced Triticum 1800 Company by inserting a modified 5- aestivum enolpyruvylshikimate-3-phosphate synthase (Wheat) (EPSPS) encoding gene from the soil bacterium Agrobacterium tumefaciens, strain CP4. SWP96 Cyanamid Selection for a mutagenized version of the Triticum 5001 Crop enzyme acetohydroxyacid synthase (AHAS), aestivum Protection also known as acetolactate synthase (ALS) (Wheat) or acetolactate pyruvate-lyase. Teal BASF Inc. Selection for a mutagenized version of the Triticum 11A enzyme acetohydroxyacid synthase (AHAS) , aestivum also known as acetolactate synthase (ALS) (Wheat) or acetolactate pyruvate-lyase. 176 Syngenta Insect-resistant maize produced by inserting Zea mays Seeds, Inc. the cry1Ab gene from Bacillus thuringiensis L. (Maize) subsp. kurstaki. The genetic modification affords resistance to attack by the European corn borer (ECB). HCN92 Bayer Introduction of the PPT-acetyltransferase Brassica CropScience (PAT) encoding gene from Streptomyces napus (Aventis viridochromogenes, an aerobic soil bacteria. (Argentine CropScience PPT normally acts to inhibit glutamine Canola) (AgrEvo)) synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. 3272 Syngenta Self processing corn (alpha-amylase); US Zea mays US 2006- Participations 2006-230473 L. (Maize) 230473, AG US2010063265 3751IR Pioneer Selection of somaclonal variants by culture Zea mays Hi-Bred of embryos on imidazolinone containing L. (Maize) International media. Inc. 676, Pioneer Male-sterile and glufosinate ammonium Zea mays 678, Hi-Bred herbicide tolerant maize produced by L. (Maize) 680 International inserting genes encoding DNA adenine Inc. methylase and phosphinothricin acetyltransferase (PAT) from Escherichia coli and Streptomyces viridochromogenes, respectively. ACS- Bayer Stacked insect resistant and herbicide Zea mays ZMØØ CropScience tolerant corn hybrid derived from L. (Maize) 3-2 x (Aventis conventional cross-breeding of the parental ØØ81Ø- MON- lines T25 (OECD identifier: ACS-ZMØØ3- 6 CropScience 2) and MON810 (OECD identifier:MON- (AgrE vo)) ØØ81Ø-6). B16 DEKALB Glufosinate resistance; US 2003-126634 Zea mays US 2003- GENETICS L. (Maize) 126634 CORP B16 Dekalb Glufosinate ammonium herbicide tolerant Zea mays (DLL25) Genetics maize produced by inserting the gene L. (Maize) Corporation encoding phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus. BT11 Syngenta Insect-resistant and herbicide tolerant maize Zea mays WO (X4334 Seeds, Inc. produced by inserting the cry1Ab gene from L. (Maize) 2010148268 CBR, Bacillus thuringiensis subsp. kurstaki, and X4734 the phosphinothricin N-acetyltransferase CBR) (PAT) encoding gene from S. viridochromogenes. BT11 x Syngenta Stacked insect resistant and herbicide Zea mays GA21 Seeds, Inc. tolerant maize produced by conventional L. (Maize) cross breeding of parental lines BT11 (OECD unique identifier: SYN-BTØ11-1) and GA21 (OECD unique identifier: MON- ØØØ21-9). BT11 x Syngenta Stacked insect resistant and herbicide Zea mays MIR16 Seeds, Inc. tolerant maize produced by conventional L. (Maize) 2 cross breeding of parental lines BT11 (OECD unique identifier: SYN-BTØ11-1) and MIR162 (OECD unique identifier: SYN-IR162-4). Resistance to the European Corn Borer and tolerance to the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S. viridochromogenes. Resistance to other lepidopteran pests, including H. zea, S. frugiperda, A. ipsilon, and S. albicosta, is derived from MIR162, which contains the vip3Aa gene from Bacillus thuringiensis strain AB88. BT11 x Syngenta Bacillus thuringiensis Cry1Ab delta- Zea mays MIR16 Seeds, Inc. endotoxin protein and the genetic material L. (Maize) 2 x necessary for its production (via elements of MIR60 vector pZO1502) in Event Bt11 corn 4 (OECD Unique Identifier: SYN-BTØ11-1) x Bacillus thuringiensis Vip3Aa20 insecticidal protein and the genetic material necessary for its production (via elements of vector pNOV1300) in Event MIR162 maize (OECD Unique Identifier: SYN-IR162-4) x modified Cry3A protein and the genetic material necessary for its production (via elements of vector pZM26) in Event MIR604 corn (OECD Unique Identifier: SYN-IR6Ø4-5). MS1, Aventis Male-sterility, fertility restoration, Brassica RF1 CropScience pollination control system displaying napus =>PGS (formerly glufosinate herbicide tolerance. MS lines (Argentine 1 Plant contained the barnase gene from Bacillus Canola) Genetic amyloliquefaciens, RF lines contained the Systems) barstar gene from the same bacteria, and both lines contained the phosphinothricin N- acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus. BT11 x Syngenta Stacked insect resistant and herbicide Zea mays MIR60 Seeds, Inc. tolerant maize produced by conventional L. (Maize) 4 cross breeding of parental lines BT11 (OECD unique identifier: SYN-BTØ11-1) and MIR604 (OECD unique identifier: SYN-IR6Ø5-5). Resistance to the European Corn Borer and tolerance to the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S. viridochromogenes. Corn rootworm- resistance is derived from MIR604 which contains the mcry3A gene from Bacillus thuringiensis. BT11 x Syngenta Stacked insect resistant and herbicide Zea mays MIR60 Seeds, Inc. tolerant maize produced by conventional L. (Maize) 4 x cross breeding of parental lines BT11 GA21 (OECD unique identifier: SYN-BTØ11-1), MIR604 (OECD unique identifier: SYN- IR6Ø5-5) and GA21 (OECD unique identifier: MON-ØØØ21-9). Resistance to the European Corn Borer and tolerance to the herbicide glufosinate ammonium (Liberty) is derived from BT11, which contains the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki, and the phosphinothricin N-acetyltransferase (PAT) encoding gene from S. viridochromogenes. Corn rootworm-resistance is derived from MIR604 which contains the mcry3A gene from Bacillus thuringiensis. Tolerance to glyphosate herbcicide is derived from GA21 which contains a a modified EPSPS gene from maize CBH- Aventis Insect-resistant and glufosinate ammonium Zea mays 351 CropScience herbicide tolerant maize developed by L. (Maize) inserting genes encoding Cry9C protein from Bacillus thuringiensis subsp tolworthi and phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus. DAS- DOW Lepidopteran insect resistant and glufosinate Zea mays 06275- AgroSciences ammonium herbicide-tolerant maize variety L. (Maize) 8 LLC produced by inserting the cry1F gene from Bacillus thuringiensis var aizawai and the phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus. DAS- DOW Corn rootworm-resistant maize produced by Zea mays US 2006- 59122- AgroSciences inserting the cry34Ab1 and cry35Ab1 genes L. (Maize) 070139, US 7 LLC from Bacillus thuringiensis strain PS149B1. 2011030086 and The PAT encoding gene from Streptomyces Pioneer viridochromogenes was introduced as a Hi-Bred selectable marker; US 2006-070139 International Inc. DAS- DOW Stacked insect resistant and herbicide Zea mays 59122- AgroSciences tolerant maize produced by conventional L. (Maize) 7 x LLC cross breeding of parental lines DAS-59122- NK603 and 7 (OECD unique identifier: DAS-59122-7) Pioneer with NK603 (OECD unique identifier: Hi-Bred MON-ØØ6Ø3-6). Corn rootworm-resistance International is derived from DAS-59122-7 which Inc. contains the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Tolerance to glyphosate herbcicide is derived from NK603. DAS DOW Stacked insect resistant and herbicide Zea mays 59122- AgroSciences tolerant maize produced by conventional L. (Maize) 7 x LLC cross breeding of parental lines DAS-59122- TC1507 and 7 (OECD unique identifier: DAS-59122-7) x Pioneer and TC1507 (OECD unique identifier: DAS- NK603 Hi-Bred Ø15Ø7-1) with NK603 (OECD unique International identifier: MON-ØØ6Ø3-6). Corn Inc. rootworm-resistance is derived from DAS- 59122-7 which contains the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Lepidopteran resistance and toleraance to glufosinate ammonium herbicide is derived from TC1507. Tolerance to glyphosate herbcicide is derived from NK603. DAS- DOW Stacked insect resistant and herbicide Zea mays Ø15Ø7- AgroSciences tolerant corn hybrid derived from L. (Maize) 1 x LLC conventional cross-breeding of the parental MON- lines 1507 (OECD identifier: DAS-Ø15Ø7- ØØ6Ø3- 1) and NK603 (OECD identifier: MON- 6 ØØ6Ø3-6). DB T41 Dekalb Insect-resistant and glufosinate ammonium Zea mays 8 Genetics herbicide tolerant maize developed by L. (Maize) Corporation inserting genes encoding Cry1AC protein from Bacillus thuringiensis subsp kurstaki and phosphinothricin acetyltransferase (PAT) from Streptomyces hygroscopicus DK404 BASF Inc. Somaclonal variants with a modified acetyl- Zea mays SR CoA-carboxylase (ACCase) were selected L. (Maize) by culture of embryos on sethoxydim enriched medium. MS1, Aventis Male-sterility, fertility restoration, Brassica RF2 CropScience pollination control system displaying napus =>PGS (formerly glufosinate herbicide tolerance. MS lines (Argentine 2 Plant contained the barnase gene from Bacillus Canola) Genetic amyloliquefaciens, RF lines contained the Systems) barstar gene from the same bacteria, and both lines contained the phosphinothricin N- acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus. DP- Pioneer Corn line 98140 was genetically engineered Zea mays Ø9814 Hi-Bred to express the GAT4621 (glyphosate L. (Maize) Ø-6 International acetyltransferase) and ZM-HRA (modified (Event Inc. version of a maize acetolactate synthase) 98140) proteins. The GAT4621 protein, encoded by the gat4621 gene, confers tolerance to glyphosate-containing herbicides by acetylating glyphosate and thereby rendering it non-phytotoxic. The ZM-HRA protein, encoded by the zm-hra gene, confers tolerance to the ALS-inhibiting class of herbicides. Event Syngenta Maize line expressing a heat stable alpha- Zea mays 3272 Seeds, Inc. amylase gene amy797E for use in the dry- L. (Maize) grind ethanol process. The phosphomannose isomerase gene from E.coli was used as a selectable marker. Event Pioneer Maize event expressing tolerance to Zea mays 98140 Hi-Bred glyphosate herbicide, via expression of a L. (Maize) International modified bacterial glyphosate N- Inc. acetlytransferase, and ALS-inhibiting herbicides, vial expression of a modified form of the maize acetolactate synthase enzyme. EXP19 Syngenta Tolerance to the imidazolinone herbicide, Zea mays 10IT Seeds, Inc. imazethapyr, induced by chemical L. (Maize) (formerly mutagenesis of the acetolactate synthase Zeneca (ALS) enzyme using ethyl methanesulfonate Seeds) (EMS). FI117 Glyphosate resistance; U.S. Pat. No. 6,040,497 Zea mays L. (Maize) GA21 Monsanto Introduction, by particle bombardment, of a Zea mays U.S. Pat. No. Company modified 5-enolpyruvyl shikimate-3- L. (Maize) 6,040,497 phosphate synthase (EPSPS), an enzyme involved in the shikimate biochemical pathway for the production of the aromatic amino acids; U.S. Pat. No. 6,040,497 GA21 x Monsanto Stacked insect resistant and herbicide Zea mays U.S. Pat. No. MON8 Company tolerant corn hybrid derived from L. (Maize) 6,040,497 10 conventional cross-breeding of the parental lines GA21 (OECD identifider: MON- ØØØ21-9) and MON810 (OECD identifier: MON-ØØ81Ø-6). GAT- AVENTIS Glufosinate tolerance; WO 01/51654 Zea mays ZM1 CROPSCIENCE L. (Maize) NV GG25 DEKALB Glyphosate resistance; U.S. Pat. No. 6,040,497 Zea mays WO 01/51654 GENETICS L. (Maize) CORP MS8xR Bayer Male-sterility, fertility restoration, Brassica U.S. Pat. No. F3 CropScience pollination control system displaying napus 6,040,497 (Aventis glufosinate herbicide tolerance. MS lines (Argentine CropScience contained the barnase gene from Bacillus Canola) (AgrEvo)) amyloliquefaciens, RF lines contained the barstar gene from the same bacteria, and both lines contained the phosphinothricin N- acetyltransferase (PAT) encoding gene from Streptomyces hygroscopicus. GJ11 DEKALB Glyphosate resistance; U.S. Pat. No. 6,040,497 Zea mays GENETICS L. (Maize) CORP IT Pioneer Tolerance to the imidazolinone herbicide, Zea mays U.S. Pat. No. Hi-Bred imazethapyr, was obtained by in vitro L. (Maize) 6,040,497 International selection of somaclonal variants. Inc. LY038 Monsanto Altered amino acid composition, specifically Zea mays Company elevated levels of lysine, through the L. (Maize) introduction of the cordapA gene, derived from Corynebacterium glutamicum, encoding the enzyme dihydrodipicolinate synthase (cDHDPS) ; U.S. Pat. No. 7,157,281 MIR16 Insect resistance; WO 2007142840 Zea mays U.S. Pat. No. 2 L. (Maize) 7,157,281, US2010212051 MIR60 Syngenta Corn rootworm resistant maize produced by Zea mays WO 4 Seeds, Inc. transformation with a modified cry3A gene. L. (Maize) 2007142840 The phosphomannose isomerase gene from E.coli was used as a selectable marker; (Cry3a055); EP 1 737 290 MIR60 Syngenta Stacked insect resistant and herbicide Zea mays EP 1 737 290 4 x Seeds, Inc. tolerant maize produced by conventional L. (Maize) GA21 cross breeding of parental lines MIR604 (OECD unique identifier: SYN-IR6Ø5-5) and GA21 (OECD unique identifier: MON- ØØØ21-9). Corn rootworm-resistance is derived from MIR604 which contains the mcry3A gene from Bacillus thuringiensis. Tolerance to glyphosate herbcicide is derived from GA21. MON8 Monsanto Insect-resistant maize produced by inserting Zea mays 0100 Companpy the cry1Ab gene from Bacillus thuringiensis L. Maize ) subsp. kurstaki. The genetic modification affords resistance to attack by the European corn borer (ECB). MON8 Monsanto Insect-resistant and glyphosate herbicide Zea mays 02 Company tolerant maize produced by inserting the L. (Maize) genes encoding the Cry1Ab protein from Bacillus thuringiensis and the 5- enolpyruvylshikimate-3-phosphate synthase (EPSPS) from A. tumefaciens strain CP4. MON8 Pioneer Resistance to European corn borer (Ostrinia Zea mays 09 Hi-Bred nubilalis) by introduction of a synthetic L. (Maize) Internation cry1Ab gene. Glyphosate resistance via al Inc. introduction of the bacterial version of a plant enzyme, 5-enolpyruvyl shikimate-3- phosphate synthase (EPSPS). MON8 Monsanto Insect-resistant maize produced by inserting Zea mays 10 Company a truncated form of the cry1Ab gene from L. (Maize) Bacillus thuringiensis subsp. kurstaki HD-1. The genetic modification affords resistance to attack by the European corn borer (ECB); US 2004-180373 MS-B2 AVENTIS Male sterility; WO 01/31042 Brassica US 2004- CROPSCIENCE napus 180373 NV (Argentine Canola) MON8 Monsanto Stacked insect resistant and glyphosate Zea mays WO 01/31042 10 x Company tolerant maize derived from conventional L. (Maize) MON8 cross-breeding of the parental lines 8017 MON810 (OECD identifier: MON-ØØ81Ø- 6) and MON88017 (OECD identifier:MON- 88Ø17-3). European corn borer (ECB) resistance is derived from a truncated form of the cry1Ab gene from Bacillus thuringiensis subsp. kurstaki HD-1 present in MON810. Corn rootworm resistance is derived from the cry3Bb1 gene from Bacillus thuringiensis subspecies kumamotoensis strain EG4691 present in MON88017. Glyphosate tolerance is derived from a 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens strain CP4 present in MON88017. MON8 Monsanto Introduction, by particle bombardment, of Zea mays 32 Company glyphosate oxidase (GOX) and a modified L. (Maize) 5-enolpyruvyl shikimate-3-phosphate synthase (EPSPS), an enzyme involved in the shikimate biochemical pathway for the production of the aromatic amino acids. MON8 Monsanto Corn root worm resistant maize produced by Zea mays 63 Company inserting the cry3Bb1 gene from Bacillus L. (Maize) thuringiensis subsp. kumamotoensis. MON8 Monsanto Stacked insect resistant corn hybrid derived Zea mays 63 x Company from conventional cross-breeding of the L. (Maize) MON8 parental lines MON863 (OECD identifier: 10 MON-ØØ863-5) and MON810 (OECD identifier: MON-ØØ81Ø-6) MON8 Monsanto Stacked insect resistant and herbicide Zea mays 63 x Company tolerant corn hybrid derived from L. (Maize) MON8 conventional cross-breeding of the stacked 10 x hybrid MON-ØØ863-5 x MON-ØØ81Ø-6 NK603 and NK603 (OECD identifier:MON- ØØ6Ø3-6). MON8 Monsanto Stacked insect resistant and herbicide Zea mays 63 x Company tolerant corn hybrid derived from L. (Maize) NK603 conventional cross-breeding of the parental lines MON863 (OECD identifier:MON- ØØ863-5) and NK603 (OECD identifier: MON-ØØ6Ø3-6). MON8 MONSANTO Drought tolerance; Water deficit tolerance; Zea mays 7460 TECHNOLOGY WO 2009/111263 L. (Maize) LLC MON8 Monsanto Corn rootworm-resistant maize produced by Zea mays WO 8017 Company inserting the cry3Bb1 gene from Bacillus L. (Maize) 2009111263 thuringiensis subspecies kumamotoensis strain EG4691. Glyphosate tolerance derived by inserting a 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens strain CP4; WO2005059103 MON8 Monsanto Maize event expressing two different Zea mays WO 9034 Company insecticidal proteins from Bacillus L. (Maize) 2005/059103 thuringiensis providing resistance to number of lepidopteran pests; nsect resistance (Lepidoptera-Cry1A.105-Cry2Ab); WO 2007140256 MON8 Monsanto Stacked insect resistant and glyphosate Zea mays WO 9034 x Company tolerant maize derived from conventional L. (Maize) 2007140256 MON8 cross-breeding of the parental lines 8017 MON89034 (OECD identifier: MON- 89Ø34-3) and MON88017 (OECD identifier:MON-88Ø17-3). Resistance to Lepiopteran insects is derived from two crygenes present in MON89043. Corn rootworm resistance is derived from a single cry genes and glyphosate tolerance is derived from the 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS) encoding gene from Agrobacterium tumefaciens present in MON88017. MS- AVENTIS Male sterility/restoration; WO 01/41558 Brassica BN1/R CROPSCIENCE napus F-BN1 NV (Argentine Canola) MON8 Monsanto Stacked insect resistant and herbicide Zea mays WO 01/41558 9034 x Company tolerant maize produced by conventional L. (Maize) NK603 cross breeding of parental lines MON89034 (OECD identifier: MON-89Ø34-3) with NK603 (OECD unique identifier: MON- ØØ6Ø3-6). Resistance to Lepiopteran insects is derived from two crygenes present in MON89043. Tolerance to glyphosate herbcicide is derived from NK603. MON8 Monsanto Stacked insect resistant and herbicide Zea mays 9034 x Company tolerant maize produced by conventional L. (Maize) TC1507 cross breeding of parental lines: x MON89034, TC1507, MON88017, and MON8 DAS-59122. Resistance to the above-ground 8017 x and below-ground insect pests and tolerance DAS- to glyphosate and glufosinate-ammonium 59122- containing herbicides. 7 MON- Monsanto Stacked insect resistant and herbicide Zea mays ØØ6Ø-6 Company tolerant corn hybrid derived from L. (Maize) x conventional cross-breeding of the parental MON- lines NK603 (OECD identifier: MON- ØØ81Ø-6 ØØ6Ø3-6) and MON810 (OECD identifier: MON-ØØ81Ø-6). MON- Monsanto Stacked insect resistant and enhanced lysine Zea mays ØØ81Ø- Company content maize derived from conventional L. (Maize) 6 x cross-breeding of the parental lines LY038 MON810 (OECD identifier: MON-ØØ81Ø- 6) and LY038 (OECD identifier: REN- ØØØ38-3). MON- Monsanto Stacked insect resistant and herbicide Zea mays 00863- Company tolerant corn hybrid derived from L. (Maize) 5 x conventional cross-breeding of the parental MON- lines MON863 (OECD identifier:MON- ØØ6Ø3- ØØ863-5) and NK603 (OECD identifier: 6 MON-ØØ6Ø3-6). MON Monsanto Stacked insect resistant corn hybrid derived Zea mays ØØ863- Company from conventional cross-breeding of the L. (Maize) 5 x parental lines MON863 (OECD identifier: MON- MON-ØØ863-5) and MON810 (OECD ØØ81Ø- identifier: MON-ØØ81Ø-6) 6 MON- Monsanto Stacked insect resistant and herbicide Zea mays ØØ863- Company tolerant corn hybrid derived from L. (Maize) 5 x conventional cross-breeding of the stacked MON hybrid MON-ØØ863-5 x MON-ØØ81Ø-6 ØØ81Ø and NK603 (OECD identifier:MON- -6 x ØØ6Ø3-6). MON- ØØ6Ø3- 6 MON- Monsanto Stacked insect resistant and herbicide Zea mays ØØ21- Company tolerant corn hybrid derived from L. (Maize) 9 x conventional cross-breeding of the parental MON- lines GA21 (OECD identifider: MON- ØØ81Ø- ØØØ21-9) and MON810 (OECD identifier: 6 MON-ØØ81Ø-6). MS3 Bayer Male sterility caused by expression of the Zea mays CropScience barnase ribonuclease gene from Bacillus L. (Maize) (Aventis amyloliquefaciens; PPT resistance was via CropScience PPT-acetyltransferase (PAT). (AgrEvo)) MS6 Bayer Male sterility caused by expression of the Zea mays CropScience barnase ribonuclease gene from Bacillus L. (Maize) (Aventis amyloliquefaciens; PPT resistance was via CropScience PPT-acetyltransferase (PAT). (AgrEvo)) NS738, Pioneer Selection of somaclonal variants with altered Brassica NS1471, Hi-Bred acetolactate synthase (ALS) enzymes, napus NS1473 International following chemical mutagenesis. Two lines (Argentine Inc. (P1,P2) were initially selected with Canola) modifications at different unlinked loci. NS738 contains the P2 mutation only. NK603 Monsanto Introduction, by particle bombardment, of a Zea mays Company modified 5-enolpyruvyl shikimate-3- L. (Maize) phosphate synthase (EPSPS), an enzyme involved in the shikimate biochemical pathway for the production of the aromatic amino acids. NK603 Monsanto Stacked insect resistant and herbicide Zea mays x Company tolerant corn hybrid derived from L. (Maize) MON8 conventional cross-breeding of the parental 10 lines NK603 (OECD identifier: MON- ØØ6Ø3-6) and MON810 (OECD identifier: MON-ØØ81Ø-6). NK603 Monsanto Stacked glufosinate ammonium and Zea mays x T25 Company glyphosate herbicide tolerant maize hybrid L. (Maize) derived from conventional cross-breeding of the parental lines NK603 (OECD identifier: MON-ØØ6Ø3-6) and T25 (OECD identifier: ACS-ZMO03-2). PV- MONSANTO Glyphosate tolerance; US 2007-056056 Zea mays ZMGT TECHNOL- L. (Maize) 32 OGY (NK603) LLC PV- MONSANTO Glyphosate tolerance; US 2007292854 Zea mays US 2007- ZMGT TECHNOL- L. (Maize) 056056 32(nk6 OGY 03) LLC PV- MONSANTO Insect resistance (Cry3Bb); US 2006- Zea mays US ZMIR1 TECHNOL- 095986 L. (Maize) 2007292854 3 LOGY (MON8 LLC 63) SYN- Syngenta Stacked insect resistant and herbicide Zea mays US 2006- BTØ11- Seeds, Inc. tolerant maize produced by conventional L. (Maize) 095986 1 x cross breeding of parental lines BT11 MON- (OECD unique identifier: SYN-BTØ11-1) ØØØ21- and GA21 (OECD unique identifier: MON- 9 ØØØ21-9). T14 Bayer Glufosinate herbicide tolerant maize Zea mays CropScience produced by inserting the phosphinothricin L. (Maize) (Aventis N-acetyltransferase (PAT) encoding gene CropScience from the aerobic actinomycete Streptomyces (AgrEvo)) viridochromogenes. T14, Bayer Glufosinate herbicide tolerant maize Zea mays T25 CropScience produced by inserting the phosphinothricin L. (Maize) (Aventis N-acetyltransferase (PAT) encoding gene CropScience from the aerobic actinomycete Streptomyces (AgrEvo)) viridochromogenes. T25 x Bayer Stacked insect resistant and herbicide Zea mays MON8 CropScience tolerant corn hybrid derived from L. (Maize) 10 (Aventis conventional cross-breeding of the parental CropScience lines T25 (OECD identifier: ACS-ZMØØ3- (AgrEvo)) 2) and MON810 (OECD identifier:MON- ØØ81Ø-6). OXY- Aventis Tolerance to the herbicides bromoxynil and Brassica 235 CropScience ioxynil by incorporation of the nitrilase gene napus (formerly from Klebsiella pneumoniae. (Argentine Rhone Canola) Poulenc Inc.) TC1507 Mycogen Insect-resistant and glufosinate ammonium Zea mays (c/o Dow herbicide tolerant maize produced by L. (Maize) AgroSciences); inserting the cry1F gene from Bacillus Pioneer thuringiensis var.aizawai and the (c/o phosphinothricin N-acetyltransferase Dupont) encoding gene from Streptomyces viridochromogenes; Insect resistance (Cry1F); U.S. Pat. No. 7,435,807 TC1507 DOW Stacked insect resistant and herbicide Zea mays U.S. Pat. No. x DAS- AgroSciences tolerant maize produced by conventional L. (Maize) 7,435,807 59122- LLC cross breeding of parental lines TC1507 7 and (OECD unique identifier: DAS-Ø15Ø7-1) Pioneer with DAS-59122-7 (OECD unique Hi-Bred identifier: DAS-59122-7). Resistance to International lepidopteran insects is derived from TC1507 Inc. due the presence of the cry1F gene from Bacillus thuringiensis var. aizawai. Corn rootworm-resistance is derived from DAS- 59122-7 which contains the cry34Ab1 and cry35Ab1 genes from Bacillus thuringiensis strain PS149B1. Tolerance to glufosinate ammonium herbcicide is derived from TC1507 from the phosphinothricin N- acetyltransferase encoding gene from Streptomyces viridochromogenes. VIP103 Syngenta Insect resistance; WO 03/052073 Zea mays 4 Participations L. (Maize) AG EH92- BASF Cropcomposition; Amflora; Unique EU WO 03/052073 527 Plant identifier: BPS-25271-9 Science PHY14, Aventis Male sterility was via insertion of the Brassica PHY35 CropScience barnase ribonuclease gene from Bacillus napus (formerly amyloliquefaciens; fertility restoration by (Argentine Plant insertion of the barstar RNase inhibitor; PPT Canola) Genetic resistance was via PPT-acetyltransferase Systems) (PAT) from Streptomyces hygroscopicus. PHY36 Aventis Male sterility was via insertion of the Brassica CropScience barnase ribonuclease gene from Bacillus napus (formerly amyloliquefaciens; fertility restoration by (Argentine Plant insertion of the barstar RNase inhibitor; PPT Canola) Genetic resistance was via PPT-acetyltransferase Systems) (PAT) from Streptomyces hygroscopicus. RT73 MONSANTO Glyphosate resistance; WO 02/36831 Brassica TECHNOL- napus OGY (Argentine LLC Canola) T45 Bayer Introduction of the PPT-acetyltransferase Brassica WO 02/36831 (HCN2 CropScience (PAT) encoding gene from Streptomyces napus 8) (Aventis viridochromogenes, an aerobic soil bacteria. (Argentine CropScience PPT normally acts to inhibit glutamine Canola) (AgrEvo)) synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. HCR-1 Bayer Introduction of the glufosinate ammonium Brassica CropScience herbicide tolerance trait from transgenic B. rapa (Polish (Aventis napus line T45. This trait is mediated by the Canola) CropScience phosphinothricin acetyltransferase (PAT) (AgrEvo)) encoding gene from S. viridochromogenes. ZSR50 Monsanto Introduction of a modified 5-enol- Brassica 0/502 Company pyruvylshikimate-3-phosphate synthase rapa (Polish (EPSPS) and a gene from Achromobacter sp Canola) that degrades glyphosate by conversion to aminomethylphosphonic acid (AMPA) and glyoxylate by interspecific crossing with GT73. EE-1 MAHARA Insect resistance (Cry1Ac); WO Brinjal SHTRA 2007/091277 HYBRID SEEDS COMPA 55- Cornell Papaya ringspot virus (PRSV) resistant Carica WO 1/63-1 University papaya produced by inserting the coat papaya 2007/091277 protein (CP) encoding sequences from this (Papaya) plant potyvirus. X17-2 University Papaya ringspot virus (PRSV) resistant Carica of Florida papaya produced by inserting the coat papaya protein (CP) encoding sequences from (Papaya) PRSV isolate H1K with a thymidine inserted after the initiation codon to yield a frameshift. Also contains nptII as a selectable marker. H7-1 Monsanto Glyphosate herbicide tolerant sugar beet Beta vulgaris Company produced by inserting a gene encoding the (sugar beet) enzyme 5-enolypyruvylshikimate-3- phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens,; WO 2004-074492 RM3-3, Bejo Male sterility was via insertion of the Cichorium WO 2004- RM3-4 Zaden BV barnase ribonuclease gene from Bacillus intybus 074492 RM3-6 amyloliquefaciens; PPT resistance was via (Chicory) the bar gene from S. hygroscopicus, which encodes the PAT enzyme. DP- PIONEER Glyphosate tolerance/ALS inhibitor Zea mays 098140- HI-BRED tolerance L. (Maize) 6 INTERNA- TIONAL INC, E.I DU PONT DE NEMOURS AND COMPANY A, B Agritope Reduced accumulation of S- Cucumis WO Inc. adenosylmethionine (SAM), and melo (Melon) 2008/112019, consequently reduced ethylene synthesis, by US2010240059 introduction of the gene encoding S- adenosylmethionine hydrolase. CZW-3 Asgrow Cucumber mosiac virus (CMV), zucchini Cucurbita (USA); yellows mosaic (ZYMV) and watermelon pepo (Squash) Seminis mosaic virus (WMV) 2 resistant squash Vegetable (Curcurbita pepo) produced by inserting the Inc. coat protein (CP) encoding sequences from (Canada) each of these plant viruses into the host genome. ZW20 Upjohn Zucchini yellows mosaic (ZYMV) and Cucurbita (USA); watermelon mosaic virus (WMV) 2 resistant pepo (Squash) Seminis squash (Curcurbita pepo) produced by Vegetable inserting the coat protein (CP) encoding Inc. sequences from each of these plant (Canada) potyviruses into the host genome. 66 Florigene Delayed senescence and sulfonylurea Dianthus Pty Ltd. herbicide tolerant carnations produced by caryophyllus inserting a truncated copy of the carnation (Carnation) aminocyclopropane cyclase (ACC) synthase encoding gene in order to suppress expression of the endogenous unmodified gene, which is required for normal ethylene biosynthesis. Tolerance to sulfonyl urea herbicides was via the introduction of a chlorsulfuron tolerant version of the acetolactate synthase (ALS) encoding gene from tobacco. 4, 11, Florigene Modified colour and sulfonylurea herbicide Dianthus 15, 16 Pty Ltd. tolerant carnations produced by inserting caryophyllus two anthocyanin biosynthetic genes whose (Carnation) expression results in a violet/mauve colouration.Tolerance to sulfonyl urea herbicides was via the introduction of a chlorsulfuron tolerant version of the acetolactate synthase (ALS) encoding gene from tobacco. 959A, Florigene Introduction of two anthocyanin Dianthus 988A, Pty Ltd. biosynthetic genes to result in a caryophyllus 1226A, violet/mauve colouration; Introduction of a (Carnation) 1351A, variant form of acetolactate synthase (ALS). 1363A, 1400A 3560.4. Pioneer Glyphosate/ALS inhibitor-tolerance; WO Glycine max 3.5 Hi-Bred 2008002872 L. (Soybean) International Inc. A2704- Bayer Glufosinate ammonium herbicide tolerant Glycine max WO 12, CropScience soybean produced by inserting a modified L. (Soybean) 2008002872 A2704- (Aventis phosphinothricin acetyltransferase (PAT) 21 CropScience encoding gene from the soil bacterium (AgrEvo)) Streptomyces viridochromogenes.; WO 2006/108674 T120-7 Bayer Introduction of the PPT-acetyltransferase Beta vulgaris WO CropScience (PAT) encoding gene from Streptomyces (sugar beet) 2006/108674 (Aventis viridochromogenes, an aerobic soil bacteria. CropScience PPT normally acts to inhibit glutamine (AgrEvo)) synthetase, causing a fatal accumulation of ammonia. Acetylated PPT is inactive. A5547- Bayer Glufosinate ammonium herbicide tolerant Glycine max 127 CropScience soybean produced by inserting a modified L. (Soybean) (Aventis phosphinothricin acetyltransferase (PAT) CropScience encoding gene from the soil bacterium (AgrEvo)) Streptomyces viridochromogenes. A5547- Bayer Glufosinate tolerance; WO 2006/108675 Glycine max 35 CropScience L. (Soybean) (Aventis CropScience (AgrEvo)) DP- Pioneer High oleic acid/ALS inhibitor tolerance; Glycine max WO 305423- Hi-Bred WO 2008/054747 L. (Soybean) 2006/108675 1 International Inc. DP3560 Pioneer Soybean event with two herbicide tolerance Glycine max WO 43 Hi-Bred genes: glyphosate N-acetlytransferase, L. (Soybean) 2008/054747 International which detoxifies glyphosate, and a modified Inc. acetolactate synthase (A G94-1, DuPont High oleic acid soybean produced by Glycine max G94- Canada inserting a second copy of the fatty acid L. (Soybean) 19, Agricultural desaturase (GmFad2-1) encoding gene from G168 Products soybean, which resulted in “silencing” of the endogenous host gene. GTS Monsanto Glyphosate tolerant soybean variety Glycine max 40-3-2 Company produced by inserting a modified 5- L. (Soybean) enolpyruvylshikimate-3-phosphate synthase (EPSPS) encoding gene from the soil bacterium Agrobacterium tumefaciens. GU262 Bayer Glufosinate ammonium herbicide tolerant Glycine max CropScience soybean produced by inserting a modified L. (Soybean) (Aventis phosphinothricin acetyltransferase (PAT) CropScience encoding gene from the soil bacterium (AgrEvo)) Streptomyces viridochromogenes. MON8 Monsanto insect resistance (CryIac); WO 2009064652 Glycine max 7701 Company L. (Soybean) MON8 Monsanto altered fatty acid levels (mid-oleic and low Glycine max WO 7705 Company saturate); WO 2010037016 L. (Soybean) 2009064652 MON8 Monsanto increased oil content; WO 2010024976 Glycine max WO 7754 Company L. (Soybean) 2010037016 GTSB7 Novartis Glyphosate herbicide tolerant sugar beet Beta vulgaris WO 7 Seeds; produced by inserting a gene encoding the (sugar beet) 2010024976 Monsanto enzyme 5-enolypyruvylshikimate-3- Company phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. MON8 Monsanto stearidonic acid (SDA) comprising oil ; WO Glycine max 7769 Company 2009102873 L. (Soybean) MON8 Monsanto Glyphosate-tolerant soybean produced by Glycine max WO 9788, Company inserting a modified 5- L. (Soybean) 2009102873 MON1 enolpyruvylshikimate-3-phosphate synthase 9788 (EPSPS) encoding aroA (epsps) gene from Agrobacterium tumefaciens CP4; WO2006130436 OT96- Agriculture Low linolenic acid soybean produced Glycine max — 15 & Agri- through traditional cross-breeding to L. (Soybean) Food incorporate the novel trait from a naturally Canada occurring fanl gene mutant that was selected for low linolenic acid. W62, Bayer Glufosinate ammonium herbicide tolerant Glycine max W98 CropScience soybean produced by inserting a modified L. (Soybean) (Aventis phosphinothricin acetyltransferase (PAT) CropScience encoding gene from the soil bacterium (AgrEvo)) Streptomyces hygroscopicus. 15985 Monsanto Insect resistant cotton derived by Gossypium Company transformation of the DP5OB parent variety, hirsutum which contained event 531 (expressing L. (Cotton) Cry1Ac protein), with purified plasmid DNA containing the cry2Ab gene from B. thuringiensis subsp. kurstaki. 1143- Syngenta Insect resistance (Cry1Ab); WO Gossypium 14A Participations 2006/128569 hirsutum AG L. (Cotton) 1143- Syngenta Insect resistance (Cry1Ab); WO Gossypium WO 51B Participations 2006/128570 hirsutum 2006/128569 AG L. (Cotton) 19-51A DuPont Introduction of a variant form of acetolactate Gossypium WO Canada synthase (ALS). hirsutum 2006/128570 Agricultural L. (Cotton) Products 281-24- DOW Insect-resistant cotton produced by inserting Gossypium 236 AgroSciences the cry1F gene from Bacillus hirsutum LLC thuringiensisvar. aizawai. The PAT L. (Cotton) encoding gene from Streptomyces viridochromogenes was introduced as a selectable marker. T227-1 SES Glyphosate tolerance; US 2004-117870 Beta vulgaris EUROPE (sugar beet) N.V./S.A 3006- DOW Insect-resistant cotton produced by inserting Gossypium US 2004- 210-23 AgroSciences the cry1Ac gene from Bacillus hirsutum 117870 LLC thuringiensissubsp. kurstaki. The PAT L. (Cotton) encoding gene from Streptomyces viridochromogenes was introduced as a selectable marker. 31807/3 Calgene Insect-resistant and bromoxynil herbicide Gossypium 1808 Inc. tolerant cotton produced by inserting the hirsutum cry1Ac gene from Bacillus thuringiensis and L. (Cotton) a nitrilase encoding gene from Klebsiella pneumoniae. BXN Calgene Bromoxynil herbicide tolerant cotton Gossypium Inc. produced by inserting a nitrilase encoding hirsutum gene from Klebsiella pneumoniae. L. (Cotton) CE43- Syngenta Insect resistance (Cry1Ab); WO Gossypium 67B Participations 2006/128573 hirsutum AG L. (Cotton) CE44- Syngenta Insect resistance (Cry1Ab); WO Gossypium WO 69D Participations 2006/128571 hirsutum 2006/128573, AG L. (Cotton) US 2011020828 CE46- Syngenta Insect resistance (Cry1Ab); WO Gossypium WO 02A Participations 2006/128572 hirsutum 2006/128571 AG L. (Cotton) Cot102 Syngenta Insect-resistant cotton produced by inserting Gossypium WO Seeds, Inc. the vip3A(a) gene from Bacillus hirsutum 2006/128572 thuringiensisAB88. The APH4 encoding L. (Cotton) gene from E. coli was introduced as a selectable marker.; US 2006-130175 COT20 Syngenta Insect resistance (VIP3A); US2009181399 Gossypium US 2006- 2 Seeds, Inc. hirsutum 130175, L. (Cotton) WO2004039986, US 2010298553 Cot67B Syngenta Insect-resistant cotton produced by inserting Gossypium — Seeds, Inc. a full-length cry1Ab gene from Bacillus hirsutum thuringiensis. The APH4 encoding gene L. (Cotton) from E. coli was introduced as a selectable marker. 23-18- Monsanto High laurate (12:0) and myristate (14:0) Brassica 17, 23- Company canola produced by inserting a thioesterase napus 198 (formerly encoding gene from the California bay laurel (Argentine Calgene) (Umbellularia californica). Canola) DAS- DOW WideStrike ™, a stacked insect-resistant Gossypium 21Ø23- AgroSciences cotton derived from conventional cross- hirsutum 5 x LLC breeding of parental lines 3006-210-23 L. (Cotton) DAS- (OECD identifier: DAS-21Ø23-5) and 281- 24236- 24-236 (OECD identifier: DAS-24236-5). 5 DAS- DOW Stacked insect-resistant and glyphosate- Gossypium 21023- AgroSciences tolerant cotton derived from conventional hirsutum 5 x LLC cross-breeding of WideStrike cotton (OECD L. (Cotton) DAS- and identifier: DAS-21Ø23-5 x DAS-24236-5) 24236- Pioneer with MON88913, known as RoundupReady 5 x Hi-Bred Flex (OECD identifier: MON-88913-8). MON8 International 8913 Inc. DAS- DOW WideStrikeT ™/Roundup Ready ® cotton, a Gossypium 21Ø23- AgroSciences stacked insect-resistant and glyphosate- hirsutum 5 x LLC tolerant cotton derived from conventional L. (Cotton) DAS- cross-breeding of WideStrike cotton (OECD 24236- identifier: DAS-21Ø23-5 x DAS-24236-5) 5 x with MON1445 (OECD identifier: MON- MON- Ø1445-2). Ø1445- 2 EE- BAYER Glyphosate tolerance; WO 2007/017186 Gossypium GH3 BIOSCIENCE hirsutum NV L. (Cotton) EE- BAYER Insect resistance (Cry1Ab); WO Gossypium WO GH5 BIOSCIENCE 2008/122406 hirsutum 2007/017186 NV L. (Cotton) EE- BAYER Insect resistance (cry2Ae); WO2008151780 Gossypium WO GH6 BIOSCIENCE hirsutum 2008/122406 NV L. (Cotton) event DOW Insect resistance (Cry1F); WO 2005/103266 Gossypium WO2008151780, 281-24- AgroSciences hirsutum US2010218281 236 LLC L. (Cotton) Event-1 JK Agri Insect-resistant cotton produced by inserting Gossypium WO Genetics the cry1Ac gene from Bacillus thuringiensis hirsutum 2005/103266 Ltd (India) subsp. kurstaki HD-73 (B.t.k.). L. (Cotton) event30 DOW Insect resistance (Cry1Ac); WO Gossypium 06-210- AgroSciences 2005/103266 hirsutum 23 LLC L. (Cotton) GBH61 Bayer Glyphosate herbicide tolerant cotton Gossypium WO 4 CropScience produced by inserting 2mepsps gene into hirsutum 2005/103266 (Avents variety Coker312 by Agrobacterium under L. (Cotton) CropSciience the control of Ph4a748At and TPotpC (AgrEvo)) 45A37, Pioneer High oleic acid and low linolenic acid Brassica 46A40 Hi-Bred canola produced through a combination of napus International chemical mutagenesis to select for a fatty (Argentine Inc. acid desaturase mutant with elevated oleic Canola) acid, and traditional back-crossing to introduce the low linolenic acid trait. LLCott Bayer Glufosinate ammonium herbicide tolerant Gossypium on25 CropScience cotton produced by inserting a modified hirsutum (Aventis phosphinothricin acetyltransferase (PAT) L. (Cotton) CropScience encoding gene from the soil bacterium (AgrEvo)) Streptomyces hygroscopicus; WO 2003013224, WO 2007/017186 LLCott Bayer Stacked herbicide tolerant and insect Gossypium WO on25 x CropScience resistant cotton combining tolerance to hirsutum 2003013224, MON1 (Aventis glufosinate ammonium herbicide from L. (Cotton) WO 5985 CropScience LLCotton25 (OECD identifier: ACS- 2007/017186 (AgrEvo)) GHØØ1-3) with resistance to insects from MON15985 (OECD identifier: MON- 15985-7) MON MONSANTO Insect resistance (Cry1A/Cry2Ab); US Gossypium 15985 TECHNOL- 2004-250317 hirsutum OGY L. (Cotton) LLC MON1 Monsanto Glyphosate herbicide tolerant cotton Gossypium US 2004- 445/169 Company produced by inserting a naturally glyphosate hirsutum 250317 8 tolerant form of the enzyme 5-enolpyruvyl L. (Cotton) shikimate-3-phosphate synthase (EPSPS) from A. tumefaciens strain CP4. MON1 Monsanto Stacked insect resistant and glyphosate Gossypium 5985 x Company tolerant cotton produced by conventional hirsutum MON8 cross-breeding of the parental lines L. (Cotton) 8913 MON88913 (OECD identifier: MON- 88913-8) and 15985 (OECD identifier: MON-15985-7). Glyphosate tolerance is derived from MON88913 which contains two genes encoding the enzyme 5- enolypyruvylshikimate-3-phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens. Insect resistance is derived MON15985 which was produced by transformation of the DP50B parent variety, which contained event 531 (expressing Cry1Ac protein), with purified plasmid DNA containing the cry2Ab gene from B. thuringiensis subsp. kurstaki. MON- Monsanto Stacked insect resistant and herbicide Gossypium 15985- Company tolerant cotton derived from conventional hirsutum 7 x cross-breeding of the parental lines 15985 L. (Cotton) MON- (OECD identifier: MON-15985-7) and Ø1445- MON1445 (OECD identifier: MON-Ø1445- 2 2). MONS Monsanto Insect-resistant cotton produced by inserting Gossypium 31/757/ Company the cry1Ac gene from Bacillus thuringiensis hirsutum 1076 subsp. kurstaki HD-73 (B.t.k.). L. (Cotton) MON8 Monsanto Glyphosate herbicide tolerant cotton Gossypium 8913 Company produced by inserting two genes encoding hirsutum the enzyme 5-enolypyruvylshikimate-3- L. (Cotton) phosphate synthase (EPSPS) from the CP4 strain of Agrobacterium tumefaciens,; WO 2004/072235 MON- Monsanto Stacked insect resistant and herbicide Gossypium WO ØØ531- Company tolerant cotton derived from conventional hirsutum 2004/072235 6 x cross-breeding of the parental lines L. (Cotton) MON- MON531 (OECD identifier: MON-00531- Ø1445- 6) and MON1445 (OECD identifier: MON- 2 Ø1445-2). 46A12, Pioneer Combination of chemical mutagenesis, to Brassica 46A16 Hi-Bred achieve the high oleic acid trait, and napus International traditional breeding with registered canola (Argentine Inc. varieties. Canola) PV- MONSANTO Glyphosate tolerance; US 2004-148666 Gossypium GHGT0 TECHNOL- hirsutum 7 OGY L. (Cotton) (1445) LLC T304- BAYER Insect-resistance (Cry1Ab); Gossypium US 2004- 40 BIOSCIENCE WO2008/122406 hirsutum 148666 NV L. (Cotton) T342- Syngenta Insect resistance (Cry1Ab); WO Gossypium WO2008/122406, 142 Participations 2006/128568 hirsutum US2010077501 AG L. (Cotton) X81359 BASF Inc. Tolerance to imidazolinone herbicides by Helianthus WO selection of a naturally occurring mutant. annuus 2006/128568 (Sunflower) RH44 BASF Inc. Selection for a mutagenized version of the Lens enzyme acetohydroxyacid synthase (AHAS)(AHAS), culinaris also known as acetolactate synthase (ALS) (Lentil) or acetolactate pyruvate-lyase. FP967 University A variant form of acetolactate synthase Linum of (ALS) was obtained from a chlorsulfuron usitatissimum Saskatchewan, tolerant line of A. thaliana and used to L. (Flax, Crop transform flax. Linseed) Dev. Centre 5345 Monsanto Resistance to lepidopteran pests through the Lycopersicon Company introduction of the cry1Ac gene from esculentum Bacillus thuringiensis subsp. Kurstaki. (Tomato) 8338 Monsanto Introduction of a gene sequence encoding Lycopersicon Company the enzyme 1-amino-cyclopropane-1- esculentum carboxylic acid deaminase (ACCd) that (Tomato) metabolizes the precursor of the fruit ripening hormone ethylene. 1345-4 DNA Plant Delayed ripening tomatoes produced by Lycopersicon Technology inserting an additional copy of a truncated esculentum Corporation gene encoding 1-aminocyclopropane-1- (Tomato) carboxyllic acid (ACC) synthase, which resulted in downregulation of the endogenous ACC synthase and reduced ethylene accumulation. 35 1 N Agritope Introduction of a gene sequence encoding Lycopersicon Inc. the enzyme S-adenosylmethionine hydrolase esculentum that metabolizes the precursor of the fruit (Tomato) ripening hormone ethylene 127 BASF ALS/AHAS inhibitor-tolerance Glycine max AGROCHE- L. (Soybean) MICAL PRODUCTS B.V. 5307 Syngenta Insect (corn rootworm) resistance (FR8a) Zea mays WO2010080829 Participations L. (Maize) AG 17053 MONSANTO Glyphosate tolerance Oryza WO2010077816 TECHNOL- sativa (Rice) OGY LLC 17314 BAYER Glyphosate tolerance Oryza WO2010117737 BIOSCIENCE sativa (Rice) NV 3560.4. Pioneer Glyphosate/ALS inhibitor-tolerance Glycine max WO2010117735 3.5 Hi-Bred L. (Soybean) International Inc. A2704- BAYER Glufosinate tolerance Glycine max WO 12 BIOSCIENCE L. (Soybean) 2008002872, NV US2010184079 A5547- BAYER Glufosinate tolerance Glycine max WO 35 BIOSCIENCE L. (Soybean) 2006/108674 NV GM Syngenta Beet Necrotic Yellow Vein Virus (BNYVV) Beta vulgaris WO RZ13 Participations resistance (sugar beet) 2006/108675 AG JOPLI Syngenta disease (fungal) resistance (trichothecene 3- Wheat WO2010076212 N1 Participations O-acetyltransferase) AG LLcotto BAYER Glufosinate resistance Gossypium US n25 BIOSCIENCE hirsutum 2008064032 NV L. (Cotton) MS-B2 AVENTIS Male sterility Brassica (A WO CROPSCIENCE genome) 2003013224 N.V. MS- AVENTIS Male sterility/restoration Brassica WO 01/31042 BN1/R CROPSCIENCE (napus) F-BN1 N.V. RT73 MONSANTO Glyphosate resistance Brassica WO 01/41558 TECHNOL- (napus) OGY LLC Kefeng CHINA Transgenic rice Kefeng 6 is a transformation Oryza WO 02/36831 No. 6 NAT event containing two insect-resistant genes, sativa (Rice) RICE RES cry1Ac and SCK (modified CpTI gene) in INST China. E6611. Pioneer 1) MS45: anther-specific 5126 (Zea mays) zea mays CN 101824411 32.1.38/ Hi-Bred promoter > fertility restoration Ms45 (Zea L. (Maize) DP- International mays) coding sequence > fertility restoration 32138- Inc. Ms45 (Zea mays) 3′-untranslated region 2) 1/ ZM-AA1: polygalacturonase 47 (Zea mays) 32138 promoter > brittle-1 (Zea mays) chloroplast transit peptide > alpha-amylase-1 (Zea mays) truncated coding sequence >> In2-1 (Zea mays) 3′-untranslated region 3) DSRED2: 35S (Cauliflower Mosaic Virus) enhancer > lipid transfer protein-2 (Hordeum vulgare) promoter > red fluorescent protein (Dicosoma sp.) variant coding sequence > protein inhibitor II (Solanum tuberosum) 3′-untranslated region DAS- DOW RB7 MARv3 > zmUbiquitin 1 Zea mays WO 40278- AgroSciences promoter > aad1 > zmPER5 3′UTR > RB 7 L. (Maize) 2009103049, 9 LLC MARv4. The aad-1 gene confers tolerance MX to 2,4-dichlorophenoxyacetic acid and 2010008977 aryloxyphenoxypropionate (commonly referred to as “fop” herbicides such as quizalofop) herbicides MIR60 Syngenta 1) CRY3A: metallotionin-like gene (Zea Zea mays WO 2011022469 4 Participations mays) promoter > delta-endotoxin cry3a L. (Maize) AG (Bacillus thuringiensis subsp. tenebrionis) coding sequence, modified to include a cathepsin-G protease recognition site and maize codon optimized > nopaline synthase (Agrobacterium tumefaciens) 3′-untranslated region 2) PMI: polyubiquitin (Zea mays) promoter (incl. first intron) > mannose-6- phosphate isomerase (Escherichia coli) ′ coding sequence > nopaline synthase (Agrobacterium tumefaciens) 3′-untranslated region MON MONSANTO Dicamba herbicide tolerance, transformation Glycine max US 87708 TECHNOL- vector PV-GMHT4355 1) DMO: full length L. (Soybean) 2005216970, OGY transcript (Peanut Chlorotic Streak Virus) US LLC promoter > tobacco Etch Virus leader > 2008167456, ribulose 1,5-biphosphate carboxylase small US subunit (Pisum sativum) chloroplast transit 2011111420 peptide > dicamba mono-oxygenase (Stenotrophomonas maltophilia) coding sequence > ribulose-1,5-bisphosphate carboxylase small subunit E9 (Pisum sativum) 3′-untranslated region. A CP4 epsps chimeric gene contained within a second T-DNA on the transformation vector used was segregated away. MON MONSANTO The transgene insert and expression cassette Zea mays WO 2011034704 87427 TECHNOL- of MON 87427 comprises the promoter and L. (Maize) OGY leader from the cauliflower mosaic virus LLC (CaMV) 35 S containing a duplicated enhancer region (P-e35S); operably linked to a DNA leader derived from the first intron from the maize heat shock protein 70 gene (I-HSP70); operably linked to a DNA molecule encoding an N-terminal chloroplast transit peptide from the shkG gene from Arabidopsis thaliana EPSPS (Ts- CTP2); operably linked to a DNA molecule derived from the aroA gene from the Agrobacterium sp. strain CP4 and encoding the CP4 EPSPS protein; operably linked to a 3′ UTR DNA molecule derived from the nopaline synthase (T-NOS) gene from Agrobacterium tumefaciens . EE- BAYER 1) Ph4a748 ABBC: sequence including the Glycine max WO GM3/ BIOSCIENCE promoter region of the histone H4 gene of L. (Soybean) 2011062904 FG72 NV Arabidopsis thaliana, containing an internal [BE]; MS duplication > 5′tev: sequence including the TECHNOL- leader sequence of the tobacco etch OGIES virus > TPotp Y: coding sequence of an LLC [US] optimized transit peptide derivative (position 55 changed into Tyrosine), containing sequence of the RuBisCO small subunit genes of Zea mays (corn) and Helianthus annuus (sunflower) > hppdPf W336: the coding sequence of the 4- hydroxyphenylpyruvate dioxygenase of Pseudomonas fluorescens strain A32 modified by the replacement of the amino acid Glycine 336 with a Tryptophane > 3′nos: sequence including the 3′ untranslated region of the nopaline synthase gene from the T-DNA of pTiT37 of Agrobacterium tumefaciens. 2) Ph4a748: sequence including the promoter region of the histone H4 gene of Arabidopsis thaliana > intron1 h3At: first intron of gene II of the histone H3.III variant of Arabidopsis thaliana >TPotp C: coding sequence of the optimized transit peptide, containing sequence of the RuBisCO small subunit genes of Zea mays (corn) and Helianthus annuus (sunflower) > 2mepsps: the coding sequence of the double-mutant 5-enol- pyruvylshikimate-3-phosphate synthase gene of Zea mays > 3′histonAt: sequence including the 3′ untranslated region of the histone H4 gene of Arabidopsis thaliana 416/ DOW A novel aad-12 transformation event for Glycine max WO 2011063411 pDAB4 AGRO- herbicide tolerance in soybean plants- L. (Soybean) 468- SCIENCES referred to herein as pDAB4468-0416. The 0416 LLC aad-12 gene (originally from Delftia acidovorans) encodes the aryloxyalkanoate dioxygenase (AAD-12) protein. The trait confers tolerance to 2,4- dichlorophenoxyacetic acid, for example, and to pyridyloxyacetate herbicides. The aad-12 gene, itself, for herbicide tolerance in plants was first disclosed in WO 2007/053482. DP- Pioneer cry1F, cry34Ab1, cry35Ab1, and pat: Zea mays WO 004114 Hi-Bred resistance to certain lepidopteran and L. (Maize) 2011066384 3 International coleopteran pests, as well as tolerance to Inc. phosphinothricin. DP- Pioneer Cry1F, cry34Ab1, cry35Ab1, pat: resistance Zea mays US 2011154523 032316- Hi-Bred to certain lepidopteran and coleopteran L. (Maize) 8 International pests, as well as tolerance to Inc. phosphinothricin DP- Pioneer Cry1F, cry34Ab1, cry35Ab1, pat: resistance Zea mays US 2011154524 040416- Hi-Bred to certain lepidopteran and coleopteran L. (Maize) 8 a International pests, as well as tolerance to Inc. phosphinothricin DP- Pioneer Cry1F, cry34Ab1, cry35Ab1, pat: resistance Zea mays US20110154525 043A47- Hi-Bred to certain lepidopteran and coleopteran L. (Maize) US20110154526 3 International pests, as well as tolerance to Inc. phosphinothricin DP- PIONEER The invention provides DNA compositions maize WO2011/08462 004114- HI-BRED that relate to transgenic insect resistant 1A1 3 INTERNA- maize plants. Also provided are assays for TIONAL, detecting the presence of the maize DP- INC./E.I. 004114-3 event based on the DNA sequence DU PONT of the recombinant construct inserted into DE the maize genome and the DNA sequences NEMOURS flanking the insertion site. Kits and AND conditions useful in conducting the assays COMPANY are provided. DP- PIONEER The invention provides DNA compositions maize WO2011/084632 032316- HI-BRED that relate to transgenic insect resistant 8 INTERNA- maize plants. Also provided are assays for TIONAL, detecting the presence of the maize DP- INC./E.I. 032316-8 event based on the DNA sequence DU PONT of the recombinant construct inserted into DE the maize genome and the DNA sequences NEMOURS flanking the insertion site. Kits and AND conditions useful in conducting the assays COMPANY are provided. MON- MONSANTO The invention provides plants comprising brassica WO2011/153186 88302- TECHNOL- transgenic event MON 88302 that exhibit 9 OGY tolerance to glyphosate herbicide. The LLC invention also provides seeds, plant parts, cells, commodity products, and methods related to the event. The invention also provides DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a Brassica napus plant. SYN- SYNGENTA Soybean plants comprising event soybean WO2012/08254 000H2- PARTICI- SYHT0H2, methods of detecting and using 8A2 5 PATIONS the same, and soybean plants comprising a AG heterologous insert at the same site as SYHT0H2. DAS- DOW This invention relates to soybean event soybean WO2012/07542 14536- AGRO- pDAB8291.45.36.2, which includes a novel 9A1 7 SCIENCES expression cassette comprising multiple LLC; MS traits conferring resistance to glyphosate, TECHNOL- aryloxyalkanoate, and glufosinate OGIES herbicides. This invention also relates in part LLC to methods of controlling resistant weeds, plant breeding, and herbicide tolerant plants. In some embodiments, the event sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect-inhibitory proteins. This invention further relates in part to detection methods, including endpoint TaqMan PCR assays, for the detection of Event pDAB8291.45.36.2 in soybeans and related plant material. Some embodiments can perform high throughput zygosity analysis of plant material and other embodiments can be used to uniquely identify the zygosity of and breed soybean lines comprising the event of the subject invention. Kits and conditions useful in conducting these assays are also provided. DAS- DOW This invention relates in part to soybean soybean WO2012/07542 44406- AGRO- event pDAB8264.44.06.1 and includes a 6A1 6 SCIENCES novel expression cassettes and transgenic LLC; MS inserts comprising multiple traits conferring TECHNOL- resistance to glyphosate, aryloxyalkanoate, OGIES and glufosinate herbicides. This invention LLC also relates in part to methods of controlling resistant weeds, plant breeding and herbicide tolerant plants. In some embodiments, the event sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect- inhibitory proteins. This invention further relates in part to endpoint TaqMan PCR assays for the detection of Event pDAB8264.44.06.1 in soybeans and related plant material. Some embodiments can perform high throughput zygosity analysis of plant material and other embodiments can be used to uniquely identify the zygosity of and breed soybean lines comprising the event of the subject invention. Kits and conditions useful in conducting these assays are also provided. MON- MONSANTO The present invention provides a transgenic soybean WO2012/05119 87712- TECHNOL- soybean comprising event MON87712 that 9A2 4 OGY exhibits increased yield. The invention also LLC provides cells, plant parts, seeds, plants, commodity products related to the event, and DNA molecules that are unique to the event and were created by the insertion of transgenic DNA into the genome of a soybean plant. The invention further provides methods for detecting the presence of said soybean event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said soybean event. DAS DOW This invention relates to soybean event soybean WO2012/03379 21606- AGRO- pDAB4472-1606 (Event 1606). This 4A2 3 SCIENCES invention includes a novel aad-12 LLC transformation event in soybean plants comprising a polynucleotide sequence, as described herein, inserted into a specific site within the genome of a soybean cell. This invention also relates in part to plant breeding and herbicide tolerant plants. In some embodiments, said event/ polynucleotide sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect-inhibitory proteins. DP- PIONEER Compositions and methods related to Brassica WO201204926 061061- HI-BRED transgenic glyphosate tolerant Brassica 8A1 7 INTERNA- plants are provided. Specifically, the present TIONAL invention provides Brassica plants having a INC. DP-061061-7 event which imparts tolerance to glyphosate. The Brassica plant harboring the DP-061061-7 event at the recited chromosomal location comprises genomic/transgene junctions within SEQ ID NO: 2 or with genomic/transgene transgene junctions as set forth in SEQ ID NO: 12 and/or 13. The characterization of the genomic insertion site of events provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the events are provided. DP- PIONEER Compositions and methods related to Brassica WO201204966 073496- HI-BRED transgenic glyphosate tolerant Brassica 1A1 4 INTERNA- plants are provided. Specifically, the present TIONAL invention provides Brassica plants having a INC. DP-073496-4 event which imparts tolerance to glyphosate. The Brassica plant harboring the DP-073496-4 event at the recited chromosomal location comprises genomic/transgene junctions within SEQ ID NO: 2 or with genomic/transgene junctions as set forth in SEQ ID NO: 12 and/or 13. The characterization of the genomic insertion site of the event provides for an enhanced breeding efficiency and enables the use of molecular markers to track the transgene insert in the breeding populations and progeny thereof. Various methods and compositions for the identification, detection, and use of the event are provided. 8264.44. DOW This invention relates in part to soybean Soybean WO201205246 06.1 AGRO- event pDAB8264.44.06.1 and includes a 8A2 SCIENCES novel expression cassettes and transgenic LLC; MS inserts comprising multiple traits conferring TECHNOL- resistance to glyphosate, aryloxyalkanoate, OGIES and glufosinate herbicides. This invention LLC also relates in part to methods of controlling resistant weeds, plant breeding and herbicide tolerant plants. In some embodiments, the event sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect- inhibitory proteins. This invention further relates in part to endpoint TaqMan PCR assays for the detection of Event pDAB8264.44.06.1 in soybeans and related plant material. Some embodiments can perform high throughput zygosity analysis of plant material and other embodiments can be used to uniquely identify the zygosity of and breed soybean lines comprising the event of the subject invention. Kits and conditions useful in conducting these assays are also provided. 8291.45. DOW This invention relates to soybean event Soybean WO201205598 36.2 AGRO- pDAB8291.45.36.2, which includes a novel 2A2 SCIENCES expression cassette comprising multiple LLC; MS traits conferring resistance to glyphosate, TECHNOL- aryloxyalkanoate, and glufosinate OGIES herbicides. This invention also relates in part LLC to methods of controlling resistant weeds, plant breeding, and herbicide tolerant plants. In some embodiments, the event sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect-inhibitory proteins. This invention further relates in part to detection methods, including endpoint TaqMan PCR assays, for the detection of Event pDAB8291.45.36.2 in soybeans and related plant material. Some embodiments can perform high throughput zygosity analysis of plant material and other embodiments can be used to uniquely identify the zygosity of and breed soybean lines comprising the event of the subject invention. Kits and conditions useful in conducting these assays are also provided. SYHT0 SYNGENTA Soybean plants comprising event soybean WO2012/08254 H2 PARTICIPA- SYHTOH2, methods of detecting and using 8A2 TIONS the same, and soybean plants comprising a AG heterologous insert at the same site as SYHT0H2. MON8 MONSANTO The invention provides cotton event MON cotton WO2012/13480 8701 TECHNOL- 88701, and plants, plant cells, seeds, plant 8A1 OGY parts, and commodity products comprising LLC event MON 88701. The invention also provides polynucleotides specific for event MON 88701 and plants, plant cells, seeds, plant parts, and commodity products comprising polynucleotides specific for event MON 88701. The invention also provides methods related to event MON 88701. KK179- MONSANTO The present invention provides a transgenic alfalfa WO201300355 2 TECHNOL- alfalfa event KK179-2. The invention also 8A1 OGY provides cells, plant parts, seeds, plants, LLC ; commodity products related to the event, FORAGE and DNA molecules that are unique to the GENETICS event and were created by the insertion of INTERNA- transgenic DNA into the genome of a alfalfa TIONAL plant. The invention further provides LLC methods for detecting the presence of said alfalfa event nucleotide sequences in a sample, probes and primers for use in detecting nucleotide sequences that are diagnostic for the presence of said alfalfa event. pDAB8 DOW This invention relates to soybean event soybean WO201301009 264.42. AGRO- pDAB8264.42.32.1 and includes novel 4A1 32.1 SCIENCES expression cassettes and transgenic inserts LLC ; MS comprising multiple traits conferring TECHNOL- resistance to glyphosate, aryloxyalkanoate, OGIES and glufosinate herbicides. This invention LLC also relates in part to methods of controlling resistant weeds, plant breeding and herbicide tolerant plants. In some embodiments, the event sequence can be “stacked” with other traits, including, for example, other herbicide tolerance gene(s) and/or insect- inhibitory proteins. This invention further relates in part to endpoint TAQMAN PCR assays for the detection of Event pDAB8264.42.32.1 in soybeans and related plant material. Some embodiments can perform high throughput zygosity analysis of plant material and other embodiments can be used to uniquely identify the zygosity of and breed soybean lines comprising the event of the subject invention. Kits and conditions useful in conducting these assays are also provided. MZDT SYNGNETA A transgenic corn event designated maize WO201301277 09Y PARTICIPA- MZDTO9Y is disclosed. The invention 5A1 TIONS relates to nucleic acids that are unique to AG event MZDTO9Y and to methods of detecting the presence of event MZDTO9Y based on DNA sequences of the recombinant constructs inserted into the corn genome that resulted in the MZDTO9Y event and of genomic sequences flanking the insertion site. The invention further relates to corn plants comprising the transgenic genotype of event MZDTO9Y and to methods for producing a corn plant by cross 

 ing a corn plant comprising the MZDTO9Y genotype with itself or another corn variety. Seeds of corn plants comprising the MZDTO9Y genotype are also objects of the invention.

Plants that may be treated according to the invention are hybrid plants that already express the characteristic of heterosis or hybrid vigor which results in generally higher yield, vigor, health and resistance towards biotic and abiotic stresses). Such plants are typically made by crossing an inbred male-sterile parent line (the female parent) with another inbred male-fertile parent line (the male parent). Hybrid seed is typically harvested from the male sterile plants and sold to growers. Male sterile plants can sometimes (e.g. in corn) be produced by detasseling, i.e. the mechanical removal of the male reproductive organs (or males flowers) but, more typically, male sterility is the result of genetic determinants in the plant genome. In that case, and especially when seed is the desired product to be harvested from the hybrid plants it is typically useful to ensure that male fertility in the hybrid plants is fully restored. This can be accomplished by ensuring that the male parents have appropriate fertility restorer genes which are capable of restoring the male fertility in hybrid plants that contain the genetic determinants responsible for male-sterility. Genetic determinants for male sterility may be located in the cytoplasm. Examples of cytoplasmic male sterility (CMS) were for instance described in Brassica species (WO 92/05251, WO 95/09910, WO 98/27806, WO 05/002324, WO 06/021972 and U.S. Pat. No. 6,229,072). However, genetic determinants for male sterility can also be located in the nuclear genome. Male sterile plants can also be obtained by plant biotechnology methods such as genetic engineering. A particularly useful means of obtaining male-sterile plants is described in WO 89/10396 in which, for example, a ribonuclease such as barnase is selectively expressed in the tapetum cells in the stamens. Fertility can then be restored by expression in the tapetum cells of a ribonuclease inhibitor such as barstar (e.g. WO 91/02069).

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may be treated according to the invention are herbicide-tolerant plants, i.e. plants made tolerant to one or more given herbicides. Such plants can be obtained either by genetic transformation, or by selection of plants containing a mutation imparting such herbicide tolerance.

Herbicide-resistant plants are for example glyphosate-tolerant plants, i.e. plants made tolerant to the herbicide glyphosate or salts thereof. Plants can be made tolerant to glyphosate through different means. For example, glyphosate-tolerant plants can be obtained by transforming the plant with a gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS). Examples of such EPSPS genes are the AroA gene (mutant CT7) of the bacterium Salmonella typhimurium (Science 1983, 221, 370-371), the CP4 gene of the bacterium Agrobacterium sp. (Curr. Topics Plant Physiol. 1992, 7, 139-145), the genes encoding a Petunia EPSPS (Science 1986, 233, 478-481), a Tomato EPSPS (J. Biol. Chem. 1988, 263, 4280-4289), or an Eleusine EPSPS (WO 01/66704). It can also be a mutated EPSPS as described in for example EP 0837944, WO 00/66746, WO 00/66747 or WO 02/26995, WO 11/000498. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate oxido-reductase enzyme as described in U.S. Pat. No. 5,776,760 and U.S. Pat. No. 5,463,175. Glyphosate-tolerant plants can also be obtained by expressing a gene that encodes a glyphosate acetyl transferase enzyme as described in for example WO 02/036782, WO 03/092360, WO 05/012515 and WO 07/024782. Glyphosate-tolerant plants can also be obtained by selecting plants containing naturally-occurring mutations of the above-mentioned genes, as described in for example WO 01/024615 or WO 03/013226. Plants expressing EPSPS genes that confer glyphosate tolerance are described in e.g. U.S. patent application Ser. Nos. 11/517,991, 10/739,610, 12/139,408, 12/352,532, 11/312,866, 11/315,678, 12/421,292, 11/400,598, 11/651,752, 11/681,285, 11/605,824, 12/468,205, 11/760,570, 11/762,526, 11/769,327, 11/769,255, 11/943,801 or 12/362,774. Plants comprising other genes that confer glyphosate tolerance, such as decarboxylase genes, are described in e.g. U.S. patent application Ser. Nos. 11/588,811, 11/185,342, 12/364,724, 11/185,560 or 12/423,926.

Other herbicide resistant plants are for example plants that are made tolerant to herbicides inhibiting the enzyme glutamine synthase, such as bialaphos, phosphinothricin or glufosinate. Such plants can be obtained by expressing an enzyme detoxifying the herbicide or a mutant glutamine synthase enzyme that is resistant to inhibition, e.g. described in U.S. patent application Ser. No. 11/760,602. One such efficient detoxifying enzyme is an enzyme encoding a phosphinothricin acetyltransferase (such as the bar or pat protein from Streptomyces species). Plants expressing an exogenous phosphinothricin acetyltransferase are for example described in U.S. Pat. Nos. 5,561,236; 5,648,477; 5,646,024; 5,273,894; 5,637,489; 5,276,268; 5,739,082; 5,908,810 and 7,112,665.

Further herbicide-tolerant plants are also plants that are made tolerant to the herbicides inhibiting the enzyme hydroxyphenylpyruvatedioxygenase (HPPD). HPPD is an enzyme that catalyze the reaction in which para-hydroxyphenylpyruvate (HPP) is transformed into homogentisate. Plants tolerant to HPPD-inhibitors can be transformed with a gene encoding a naturally-occurring resistant HPPD enzyme, or a gene encoding a mutated or chimeric HPPD enzyme as described in WO 96/38567, WO 99/24585, WO 99/24586, WO 09/144079, WO 02/046387, U.S. Pat. No. 6,768,044, WO 11/076877, WO 11/076882, WO 11/076885, WO 11/076889. WO 11/076892. WO13/026740, WO13/092552, WO13/092551 or WO12/092555. Tolerance to HPPD-inhibitors can also be obtained by transforming plants with genes encoding certain enzymes enabling the formation of homogentisate despite the inhibition of the native HPPD enzyme by the HPPD-inhibitor. Such plants and genes are described in WO 99/34008 and WO 02/36787. Tolerance of plants to HPPD inhibitors can also be improved by transforming plants with a gene encoding an enzyme having prephenate deshydrogenase (PDH) activity in addition to a gene encoding an HPPD-tolerant enzyme, as described in WO 04/024928. Further, plants can be made more tolerant to HPPD-inhibitor herbicides by adding into their genome a gene encoding an enzyme capable of metabolizing or degrading HPPD inhibitors, such as the CYP450 enzymes shown in WO 07/103567 and WO 08/150473.

Still further herbicide resistant plants are plants that are made tolerant to acetolactate synthase (ALS) inhibitors. Known ALS-inhibitors include, for example, sulfonylurea, imidazolinone, triazolo-pyrimidines, pyrimidinyoxy(thio)benzoates, and/or sulfonylaminocarbonyltriazolinone herbicides. Different mutations in the ALS enzyme (also known as acetohydroxyacid synthase, AHAS) are known to confer tolerance to different herbicides and groups of herbicides, as described for example in Tranel and Wright (Weed Science 2002, 50, 700-712), but also, in U.S. Pat. Nos. 5,605,011, 5,378,824, 5,141,870, and 5,013,659. The production of sulfonylurea-tolerant plants and imidazolinone-tolerant plants is described in U.S. Pat. Nos. 5,605,011; 5,013,659; 5,141,870; 5,767,361; 5,731,180; 5,304,732; 4,761,373; 5,331,107; 5,928,937; and 5,378,824; and WO 96/33270. Other imidazolinone-tolerant plants are also described in for example WO 04/040012, WO 04/106529, WO 05/020673, WO 05/093093, WO 06/007373, WO 06/015376, WO 06/024351, and WO 06/060634. Further sulfonylurea- and imidazolinone-tolerant plants are also described in for example WO 07/024782, WO 2011/076345, WO 2012058223, WO 2012150335 and U.S. Patent Application 61/288,958.

Other plants tolerant to imidazolinone and/or sulfonylurea can be obtained by induced mutagenesis, selection in cell cultures in the presence of the herbicide or mutation breeding as described for example for soybeans in U.S. Pat. No. 5,084,082, for rice in WO 97/41218, for sugar beet in U.S. Pat. No. 5,773,702 and WO 99/057965, for lettuce in U.S. Pat. No. 5,198,599, or for sunflower in WO 01/065922.

Plants tolerant to 2,4 D or dicamba are for example described in U.S. Pat. No. 6,153,401.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are insect-resistant transgenic plants, i.e. plants made resistant to attack by certain target insects. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such insect resistance.

An “insect-resistant transgenic plant”, as used herein, includes any plant containing at least one transgene comprising a coding sequence encoding:

-   1) an insecticidal crystal protein from Bacillus thuringiensis or an     insecticidal portion thereof, such as the insecticidal crystal     proteins listed by Crickmore et al. (Microbiology and Molecular     Biology Reviews 1998, 62, 807-813), updated by Crickmore et     al. (2005) at the Bacillus thuringiensis toxin nomenclature, online     at: http://www.lifesci.sussex.ac.uk/Home/Neil_Crickmore/Bt/), or     insecticidal portions thereof, e.g., proteins of the Cry protein     classes Cry1Ab, Cry1Ac, Cry1B, Cry1C, Cry1D, Cry1F, Cry2Ab, Cry3Aa,     or Cry3Bb or insecticidal portions thereof (e.g. EP-A 1 999 141 and     WO 07/107302), or such proteins encoded by synthetic genes as e.g.     described in and U.S. patent application Ser. No. 12/249,016; or -   2) a crystal protein from Bacillus thuringiensis or a portion     thereof which is insecticidal in the presence of a second other     crystal protein from Bacillus thuringiensis or a portion thereof,     such as the binary toxin made up of the Cry34 and Cry35 crystal     proteins (Nat. Biotechnol. 2001, 19, 668-72; Applied Environm.     Microbiol. 2006, 71, 1765-1774) or the binary toxin made up of the     Cry1A or Cry1F proteins and the Cry2Aa or Cry2Ab or Cry2Ae proteins     (U.S. patent application Ser. No. 12/214,022 and EP-A 2 300 618); or -   3) a hybrid insecticidal protein comprising parts of different     insecticidal crystal proteins from Bacillus thuringiensis, such as a     hybrid of the proteins of 1) above or a hybrid of the proteins of 2)     above, e.g., the Cry1A.105 protein produced by corn event MON89034     (WO 07/027777); or -   4) a protein of any one of 1) to 3) above wherein some, particularly     1 to 10, amino acids have been replaced by another amino acid to     obtain a higher insecticidal activity to a target insect species,     and/or to expand the range of target insect species affected, and/or     because of changes introduced into the encoding DNA during cloning     or transformation, such as the Cry3Bb1 protein in corn events MON863     or MON88017, or the Cry3A protein in corn event MIR604; or -   5) an insecticidal secreted protein from Bacillus thuringiensis or     Bacillus cereus, or an insecticidal portion thereof, such as the     vegetative insecticidal (VIP) proteins listed at:     -   http://www.lifesci.sussex.ac.uk/home/Neil_Crickmore/Bt/vip.html,         e.g., proteins from the VIP3Aa protein class; or -   6) a secreted protein from Bacillus thuringiensis or Bacillus cereus     which is insecticidal in the presence of a second secreted protein     from Bacillus thuringiensis or B. cereus, such as the binary toxin     made up of the VIP1A and VIP2A proteins (WO 94/21795); or -   7) a hybrid insecticidal protein comprising parts from different     secreted proteins from Bacillus thuringiensis or Bacillus cereus,     such as a hybrid of the proteins in 1) above or a hybrid of the     proteins in 2) above; or -   8) a protein of any one of 5) to 7) above wherein some, particularly     1 to 10, amino acids have been replaced by another amino acid to     obtain a higher insecticidal activity to a target insect species,     and/or to expand the range of target insect species affected, and/or     because of changes introduced into the encoding DNA during cloning     or transformation (while still encoding an insecticidal protein),     such as the VIP3Aa protein in cotton event COT102; or -   9) a secreted protein from Bacillus thuringiensis or Bacillus cereus     which is insecticidal in the presence of a crystal protein from     Bacillus thuringiensis, such as the binary toxin made up of VIP3 and     Cry1A or Cry1F (U.S. Patent Applications 61/126,083 and 61/195,019),     or the binary toxin made up of the VIP3 protein and the Cry2Aa or     Cry2Ab or Cry2Ae proteins (U.S. patent application Ser. No.     12/214,022 and EP-A 2 300 618). -   10) a protein of 9) above wherein some, particularly 1 to 10, amino     acids have been replaced by another amino acid to obtain a higher     insecticidal activity to a target insect species, and/or to expand     the range of target insect species affected, and/or because of     changes introduced into the encoding DNA during cloning or     transformation (while still encoding an insecticidal protein)

Of course, an insect-resistant transgenic plant, as used herein, also includes any plant comprising a combination of genes encoding the proteins of any one of the above classes 1 to 10. In one embodiment, an insect-resistant plant contains more than one transgene encoding a protein of any one of the above classes 1 to 10, to expand the range of target insect species affected when using different proteins directed at different target insect species, or to delay insect resistance development to the plants by using different proteins insecticidal to the same target insect species but having a different mode of action, such as binding to different receptor binding sites in the insect.

An “insect-resistant transgenic plant”, as used herein, further includes any plant containing at least one transgene comprising a sequence producing upon expression a double-stranded RNA which upon ingestion by a plant insect pest inhibits the growth of this insect pest, as described e.g. in WO 07/080126, WO 06/129204, WO 07/074405, WO 07/080127 and WO 07/035650.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are tolerant to abiotic stresses. Such plants can be obtained by genetic transformation, or by selection of plants containing a mutation imparting such stress resistance. Particularly useful stress tolerance plants include:

-   1) plants which contain a transgene capable of reducing the     expression and/or the activity of poly(ADP-ribose) polymerase (PARP)     gene in the plant cells or plants as described in WO 00/04173, WO     06/045633, EP-A 1 807 519, or EP-A 2 018 431. -   2) plants which contain a stress tolerance enhancing transgene     capable of reducing the expression and/or the activity of the PARG     encoding genes of the plants or plants cells, as described e.g. in     WO 04/090140. -   3) plants which contain a stress tolerance enhancing transgene     coding for a plant-functional enzyme of the nicotinamide adenine     dinucleotide salvage synthesis pathway including nicotinamidase,     nicotinate phosphoribosyltransferase, nicotinic acid mononucleotide     adenyl transferase, nicotinamide adenine dinucleotide synthetase or     nicotine amide phosphoribosyltransferase as described e.g. in EP-A 1     794 306, WO 06/133827, WO 07/107326, EP-A 1 999 263, or WO     07/107326.

Plants or plant cultivars (obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention show altered quantity, quality and/or storage-stability of the harvested product and/or altered properties of specific ingredients of the harvested product such as:

-   1) transgenic plants which synthesize a modified starch, which in     its physical-chemical characteristics, in particular the amylose     content or the amylose/amylopectin ratio, the degree of branching,     the average chain length, the side chain distribution, the viscosity     behaviour, the gelling strength, the starch grain size and/or the     starch grain morphology, is changed in comparison with the     synthesised starch in wild type plant cells or plants, so that this     is better suited for special applications. Said transgenic plants     synthesizing a modified starch are disclosed, for example, in EP-A 0     571 427, WO 95/04826, EP-A 0 719 338, WO 96/15248, WO 96/19581, WO     96/27674, WO 97/11188, WO 97/26362, WO 97/32985, WO 97/42328, WO     97/44472, WO 97/45545, WO 98/27212, WO 98/40503, WO 99/58688, WO     99/58690, WO 99/58654, WO 00/08184, WO 00/08185, WO 00/08175, WO     00/28052, WO 00/77229, WO 01/12782, WO 01/12826, WO 02/101059, WO     03/071860, WO 04/056999, WO 05/030942, WO 05/030941, WO 05/095632,     WO 05/095617, WO 05/095619, WO 2005/095618, WO 05/123927, WO     06/018319, WO 06/103107, WO 06/108702, WO 07/009823, WO 00/22140, WO     06/063862, WO 06/072603, WO 02/034923, WO 08/017518, WO 08/080630,     WO 08/080631, WO 08/090008, WO 01/14569, WO 02/79410, WO 03/33540,     WO 04/078983, WO 01/19975, WO 95/26407, WO 96/34968, WO 98/20145, WO     99/12950, WO 99/66050, WO 99/53072, U.S. Pat. No. 6,734,341, WO     00/11192, WO 98/22604, WO 98/32326, WO 01/98509, WO 01/98509, WO     05/002359, U.S. Pat. No. 5,824,790, U.S. Pat. No. 6,013,861, WO     94/04693, WO 94/09144, WO 94/11520, WO 95/35026, WO 97/20936, WO     10/012796, WO 10/003701, WO 13/053729, WO 13/053730, -   2) transgenic plants which synthesize non starch carbohydrate     polymers or which synthesize non starch carbohydrate polymers with     altered properties in comparison to wild type plants without genetic     modification. Examples are plants producing polyfructose, especially     of the inulin and levan-type, as disclosed in EP-A 0 663 956, WO     96/01904, WO 96/21023, WO 98/39460, and WO 99/24593, plants     producing alpha-1,4-glucans as disclosed in WO 95/31553, US     2002031826, U.S. Pat. No. 6,284,479, U.S. Pat. No. 5,712,107, WO     97/47806, WO 97/47807, WO 97/47808 and WO 00/14249, plants producing     alpha-1,6 branched alpha-1,4-glucans, as disclosed in WO 00/73422,     plants producing alternan, as disclosed in e.g. WO 00/47727, WO     00/73422, U.S. Pat. No. 5,908,975 and EP-A 0 728 213, -   3) transgenic plants which produce hyaluronan, as for example     disclosed in WO 06/032538, WO 07/039314, WO 07/039315, WO 07/039316,     JP-A 2006-304779, and WO 05/012529. -   4) transgenic plants or hybrid plants, such as onions with     characteristics such as ‘high soluble solids content’, low pungency′     (LP) and/or ‘long storage’ (LS), as described in U.S. patent     application Ser. No. 12/020,360. -   5) Transgenic plants displaying an increase yield as for example     disclosed in WO 11/095528     -   Plants or plant cultivars (that can be obtained by plant         biotechnology methods such as genetic engineering) which may         also be treated according to the invention are plants, such as         cotton plants, with altered fiber characteristics. Such plants         can be obtained by genetic transformation, or by selection of         plants contain a mutation imparting such altered fiber         characteristics and include: -   a) Plants, such as cotton plants, containing an altered form of     cellulose synthase genes as described in WO 98/00549. -   b) Plants, such as cotton plants, containing an altered form of rsw2     or rsw3 homologous nucleic acids as described in WO 04/053219. -   c) Plants, such as cotton plants, with increased expression of     sucrose phosphate synthase as described in WO 01/17333. -   d) Plants, such as cotton plants, with increased expression of     sucrose synthase as described in WO 02/45485. -   e) Plants, such as cotton plants, wherein the timing of the     plasmodesmatal gating at the basis of the fiber cell is altered,     e.g. through downregulation of fiber-selective β-1,3-glucanase as     described in WO 05/017157, or as described in WO 09/143995. -   f) Plants, such as cotton plants, having fibers with altered     reactivity, e.g. through the expression of     N-acetylglucosaminetransferase gene including nodC and chitin     synthase genes as described in WO 06/136351, WO 11/089021, WO     11/089021, WO 12/074868.     -   Plants or plant cultivars (that can be obtained by plant         biotechnology methods such as genetic engineering) which may         also be treated according to the invention are plants, such as         oilseed rape or related Brassica plants, with altered oil         profile characteristics. Such plants can be obtained by genetic         transformation, or by selection of plants contain a mutation         imparting such altered oil profile characteristics and include: -   a) Plants, such as oilseed rape plants, producing oil having a high     oleic acid content as described e.g. in U.S. Pat. No. 5,969,169,     U.S. Pat. No. 5,840,946 or U.S. Pat. No. 6,323,392 or U.S. Pat. No.     6,063,947 -   b) Plants such as oilseed rape plants, producing oil having a low     linolenic acid content as described in U.S. Pat. No. 6,270,828, U.S.     Pat. No. 6,169,190, U.S. Pat. No. 5,965,755 or WO 11/060946 -   c) Plant such as oilseed rape plants, producing oil having a low     level of saturated fatty acids as described e.g. in U.S. Pat. No.     5,434,283 or U.S. patent application Ser. No. 12/668,303 -   d) Plants such as oilseed rape plants, producing oil having an alter     glucosinolate content as described in WO 2012075426.

Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as oilseed rape or related Brassica plants, with altered seed shattering characteristics. Such plants can be obtained by genetic transformation, or by selection of plants contain a mutation imparting such altered seed shattering characteristics and include plants such as oilseed rape plants with delayed or reduced seed shattering as described in WO 2009/068313 and WO 2010/006732, WO 2012090499.

Plants or plant cultivars (that can be obtained by plant biotechnology methods such as genetic engineering) which may also be treated according to the invention are plants, such as Tobacco plants, with altered post-translational protein modification patterns, for example as described in WO 10/121818 and WO 10/145846.

Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or combination of transformation events, that are the subject of petitions for non-regulated status, in the United States of America, to the Animal and Plant Health Inspection Service (APHIS) of the United States Department of Agriculture (USDA) whether such petitions are granted or are still pending. At any time this information is readily available from APHIS (4700 River Road, Riverdale, Md. 20737, USA), for instance on its internet site (URL http://www.aphis.usda.gov/brs/not_reg.html). On the filing date of this application the petitions for nonregulated status that were pending with APHIS or granted by APHIS were those listed in Table B which contains the following information:

-   -   Petition: the identification number of the petition. Technical         descriptions of the transformation events can be found in the         individual petition documents which are obtainable from APHIS,         for example on the APHIS website, by reference to this petition         number. These descriptions are herein incorporated by reference.     -   Extension of Petition: reference to a previous petition for         which an extension is requested.     -   Institution: the name of the entity submitting the petition.     -   Regulated article: the plant species concerned.     -   Transgenic phenotype: the trait conferred to the plants by the         transformation event.     -   Transformation event or line: the name of the event or events         (sometimes also designated as lines or lines) for which         nonregulated status is requested.     -   APHIS documents: various documents published by APHIS in         relation to the Petition and which can be requested with APHIS.

TABLE B Petition No. Applicant Crop Phenotype/Event 11-342-01p Genective Corn Glyphosate Tolerant/ VCO-Ø1981-5 11-234-01p Dow Soybean 2, 4-D, Glyphosate and Glufosinate Tolerant/DAS-444Ø6-6 11-202-01p Monsanto Soybean Increased Yield/MON 87712 11-188-01p Monsanto Canola Glyphosate Tolerant/ MON 88302 11-063-01p Pioneer Canola Glyphosate Tolerant/73496 10-281-01p Monsanto Corn Male Sterile/MON 87427 10-188-01p Monsanto Soybean Dicamba Tolerant/MON 87708 10-161-01p Okanagan Apple Non-Browning/GD743, GS784 09-015-01p BASF Soybean Imadazolinone Tolerant/ BPS-CV127-9 The following pending petitions will proceed with the previous process for soliciting public input (simultaneous notice of availability of the petition and decisionmaking documents). 12-033-01p Bayer Cotton Glufosinate Tolerant, Extension of Lepidopteran Resistant/T303-3 08-340-01p 11-244-01p Pioneer Corn Insect Resistant and Glufosinate Tolerant/DP-ØØ4114-3 10-336-01p Syngenta Corn Rootworm Resistant/ 5307 09-349-01p Dow Soybean 2,4-D and Glufosinate Tolerant/ DAS-68416-4 09-328-01p Bayer Soybean Glyphosate and Isoxaflutole Tolerant/FG72 09-233-01p Dow Corn 2,4-D and ACCase-Inhibitor Tolerant/DAS-40278-9 03-104-01p Scotts Creeping Glyphosate Tolerant/ Bentgrass ASR368 Determinations of Nonregulated Status 09-201-01p Monsanto Soybean Improved Fatty Acid Profile/ MON 87705 09-183-01p Monsanto Soybean Stearidonic Acid Produced/ MON 87769 09-082-01p Monsanto Soybean Insect Resistant/ MON 87701 09-055-01p Monsanto Corn Drought Tolerant/ MON 87460 08-340-01p Bayer Cotton Glufosinate Tolerant, Lepidopteran Resistant/ T304-40 x GHB119 08-338-01p Pioneer Corn Male Sterile, Fertility Restored, Visual Marker/ DP-32138-1 08-315-01p Florigene Rose Altered Flower Color/ IFD-52401-4, IFD-52901-9 07-253-01p Syngenta Corn Lepidopteran Resistant/ MIR 162 07-152-01p Pioneer Corn Glyphosate & Imidazolinone Tolerant/98140 07-108-01p Syngenta Cotton Lepidopteran Resistant/ COT67B 06-354-01p Pioneer Soybean High Oleic Acid/ Event 305423 06-332-01p Bayer Cotton Glyphosate Tolerant/ CropScience GHB614 06-298-01p Monsanto Corn European Corn Borer Resistant/ MON 89034 06-271-01p Pioneer Soybean Glyphosate & Acetolactate Synthase Tolerant/ DP-356Ø43-5 06-234-01p Bayer Crop ScienceRice Phosphinothricin Tolerant/ Extension of LLRICE601 98-329-01p 06-178-01p Monsanto Soybean Glyphosate Tolerant/ MON 89788 05-280-01p Syngenta Corn Thermostable Alpha-amylase/ 3272 04-362-01p Syngenta Corn Corn Rootworm Protected/ MIR604 04-337-01p University Papaya Papaya Ringspot Virus of Resistant/X17-2 Florida 04-264-01p ARS Plum Plum Pox Virus Resistant/ C5 04-229-01p Monsanto Corn High Lysine/ LY038 04-125-01p Monsanto Corn Corn Rootworm Resistant/ MON 88017 04-110- Monsanto Alfalfa Glyphosate Tolerant/ 01p_a1 & Forage J101, J103 04-110-01p Genetics 04-086-01p Monsanto Cotton Glyphosate Tolerant/ MON 88913 03-353-01p Dow Corn Corn Rootworm Resistant/ 59122 03-323- Monsanto Sugar Beet Glyphosate Tolerant/ 01p_a1 and H7-1 03-323-01p KWS SAAT AG 03-181-01p Dow Corn Lepidopteran Resistant Extension of & Phosphinothricin 00-136-01p Tolerant/ 6275 03-155-01p Syngenta Cotton Lepidopteran Resistant/ COT102 03-036-02p Mycogen/ Cotton Lepidopteran Resistant/ Dow 3006-210-23 03-036-01p Mycogen/ Cotton Lepidopteran Resistant/ Dow 281-24-236 02-042-01p Aventis Cotton Phosphinothericin Tolerant/ LLCotton25 01-324-01p Monsanto Rapeseed Glyphosate tolerant/ Extension of GT200 98-216-01p 01-206-02p Aventis Rapeseed Phosphinothricin Tolerant Extension of & Pollination Control/ 97-205-01p Topas 19/2 01-206-01p Aventis Rapeseed Phosphinothricin Tolerant/ Extension of MS1 98-T78-01p 01-137-01p Monsanto Corn Corn Rootworm Resistant/ MON 863 01-121-01p Vector Tobacco Reduced Nicotine/ Vector 21-41 00-342-01p Monsanto Cotton Lepidopteran Resistant/ 15985 00-136-01p Mycogen Corn Lepidopteran Resistant c/o Dow Phosphinothricin Tolerant/ & Pioneer 1507 00-011-01p Monsanto Corn Glyphosate Tolerant/ Extension of NK603 97-099-01p 99-173-01p Monsanto Potato Potato Leafroll Virus & Extension of Colorado Potato 97-204-01p Beetle Resistant/ RBMT22-82 98-349-01p AgrEvo Corn Phosphinothricin Tolerant Extension of and Male Sterile/MS6 95-228-01p 98-335-01p U. of Flax Tolerant to Soil Residues Saskat- of Sulfonylurea chewan Herbicide/ CDC Triffid 98-329-01p AgrEvo Rice Phosphinothricin Tolerant/ LLRICE06, LLRICE62 98-278-01p AgrEvo Rapeseed Phosphinothricin Tolerant and Pollination Control/ MS8, RF3 98-238-01p AgrEvo Soybean Phosphinothricin Tolerant/ GU262 98-216-01p Monsanto Rapeseed Glyphosate Tolerant/ RT73 98-173-01p Novartis Beet Glyphosate Tolerant/ Seeds & GTSB77 Monsanto 98-014-01p AgrEvo Soybean Phosphinothricin Tolerant/ Extension of A5547-127 96-068-01p 97-342-01p Pioneer Corn Male Sterile and Phosphinothricin Tolerant/ 676, 678, 680 97-339-01p Monsanto Potato Colorado Potato Beetle and Potato Virus Y Resistant/ RBMT15-101, SEMT15-02, SEMT15-15 97-336-01p AgrEvo Beet Phosphinothricin Tolerant/ T120-7 97-287-01p Monsanto Tomato Lepidopteran Resistant/ 5345 97-265-01p AgrEvo Corn Phosphinothricin Tolerant and Lepidopteran Resistant/ CBH-351 97-205-01p AgrEvo Rapeseed Phosphinothricin Tolerant/ T45 97-204-01p Monsanto Potato Potato Leafroll Virus & Colorado Potato Beetle Resistant/ RBMT21-129, RBMT21-152, RBMT21-350, RBMT22-82, RBMT22-186, RBMT22-238, RBMT22-262 97-148-01p Bejo Cichorium Male Sterile/ intybus RM3-3, RM3-4, RM3-6 97-099-01p Monsanto Corn Glyphosate Tolerant/ GA21 97-013-01p Calgene Cotton Bromoxynil Tolerant and Lepidopteran Resistant/ 31807, 31808 97-008-01p Du Pont Soybean High Oleic Acid Oil/ G94-1, G94-19, G-168 96-317-01p Monsanto Corn Glyphosate Tolerant and European Corn Borer Resistant/ MON 802 96-291-01p DeKalb Corn European Corn Borer Resistant/DBT418 96-248-01p Calgene Tomato Fruit Ripening Altered/ Extension of 532A 4109a 5166 92-196-01p 96-068-01p AgrEvo Soybean Glufosinate Tolerant/ W62, W98, A2704-12, A2704-21, A5547-35 96-051-01p Cornell U Papaya Papaya Ringspot Virus Resistant/55-1, 63-1 96-017-01p Monsanto Corn European Corn Extension of Borer Resistant/ 95-093-01p MON 809, MON 810 95-352-01p Asgrow Squash Cucumber Mosaic Virus, Watermelon Mosaic Virus 2, and Zucchini Yellow Mosaic Virus Resistant/ CZW-3 95-338-01p Monsanto Potato Colorado Potato Beetle Resistant/ SPBT02-5, SPBT02-7, ATBT04-6, ATBT04- 27, ATBT04-30, ATBT04-31, ATBT04-36 95-324-01p Agritope Tomato Fruit Ripening Altered/ 35-1-N 95-256-01p Du Pont Cotton Sulfonylurea Tolerant/ 19-51A 95-228-01p Plant Genetic Corn Male Sterile/MS3 Systems 95-195-01p Northrup Corn European Corn Borer Resistant/ King Bt11 95-179-01p Calgene Tomato Fruit Ripening Altered/ Extension of 519a 4109a-4645, 92-196-01p 540a 4109a-1823 95-145-01p DeKalb Corn Glufosinate Tolerant/ B16 95-093-01p Monsanto Corn Lepidopteran Resistant/ MON 80100 95-053-01p Monsanto Tomato Fruit Ripening Altered/ 8338 95-045-01p Monsanto Cotton Glyphosate Tolerant/ 1445, 1698 95-030-01p Calgene Tomato Fruit Ripening Altered/ Extension of 105F 1436 2018, 105F 92-196-01p 1436 2035, 105F 1436 2049, 35F 4109a 3023, 84F 4109a 148, 88F 4109a 2797, 121F 4109a 333, 121F 4109a 1071, 121F 4109a 1120, 137F 4109a 71, 138F 4109a 164, 519A 4109a 4527, 519A 4109a 4621, 519A 4109a 4676, 531A 4109a 2105, 531A 4109a 2270, 532A 4109a 5097, 540A 4109a 1739, 585A 4109a 3604, 585A 4109a 3530 94-357-01p AgrEvo Corn Glufosinate Tolerant/ T14, T25 94-319-01p Ciba Seeds Corn Lepidopteran Resistant/ 176 94-308-01p Monsanto Cotton Lepidopteran Resistant/ 531, 757, 1076 94-290-01p Zeneca & Tomato Fruit Polygalacturonase Petoseed Level Decreased/ B, Da, F 94-257-01p Monsanto Potato Coleopteran Resistant/ BT6, BT10, BT12, BT16, BT17, BT18, BT23 94-230-01p Calgene Tomato Fruit Ripening Altered/ Extension of 114F 4109a 26, 92-196-01p 114F 4109a 81 94-228-01p DNA Plant Tomato Fruit Ripening Altered/ Tech 1345-4 94-227-01p Calgene Tomato Fruit Ripening Altered/ Extension of pCGN1436, pCGN4109 92-196-01p 94-090-01p Calgene Rapeseed Oil Profile Altered/ pCGN3828-212/86-18, pCGN3828-212/86-23 93-258-01p Monsanto Soybean Glyphosate Tolerant/ 4-30-2 93-196-01p Calgene Cotton Bromoxynil Tolerant/ BXN 92-204-01p Upjohn Squash Watermelon Mosaic Virus and Zucchini Yellow Mosaic Virus Resistant/ZW-20 92-196-01p Calgene Tomato Fruit Ripening Altered/ pCGN1547, pCGN1548, pCGN1557, pCGN1559, pCGN1578

Additional particularly useful plants containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.cera-gmc.org/?action=gm_crop_database).

Further particularly transgenic plants include plants containing a transgene in an agronomically neutral or beneficial position as described in any of the patent publications listed in Table C.

TABLE C Trait Reference Remarks Water use efficiency WO 2000/073475 WO2009/150541 WO2009/150541 WO2012075429 WO2012077020 WO2012158594 Nitrogen use efficiency WO 1995/009911 WO 1997/030163 WO 2007/092704 WO 2007/076115 WO 2005/103270 WO 2002/002776 WO2008/051608 WO2008/112613 WO2009/015096 WO2009/061776 WO2009/105492 WO2009/105612 WO2009/117853 WO2010/006010 WO2009/117853 WO2009/061776 WO2009/015096 WO2009/105492 WO2009/105612 WO 2010/053621 WO 2010/053867 WO2010/077890 WO 2010/086220 WO 2010/111568 WO 2010/140388 WO2010/007496 WO2011/022597 WO2011/022608 WO2012087140 Improved WO 2008/056915 photosynthesis WO 2004/101751 Nematode WO 1995/020669 resistance WO 2001/051627 WO 2008/139334 WO 2008/095972 WO 2006/085966 WO 2003/033651 WO 1999/060141 WO 1998/012335 WO 1996/030517 WO 1993/018170 WO2008/095886 WO2008/095887 WO2008/095888 WO2008/095889 WO2008/095910 WO2008/095911 WO2008/095916 WO2008/095919 WO2008/095969 WO2008/095970 WO2008/095972 WO2008/110522 WO2008/139334 — WO2008/152008 — W02010/077858 — WO 2010/091230 — WO 2010/102172 — WO 2010/106163 WO2011/003783 WO2011/082217 WO2011/104153 WO2012007916 WO2012007919 WO2012009551 WO2012011034 WO2012012403 WO2012153274 WO2012156902 Reduced pod WO 2006/009649 dehiscence WO 2004/113542 WO 1999/015680 WO 1999/000502 WO 1997/013865 WO 1996/030529 WO 1994/023043 Aphid resistance WO 2006/125065 WO 1997/046080 WO 2008/067043 WO 2004/072109 WO2009/091860 WO2010036764 Sclerotinia resistance WO 2006/135717 WO 2006/055851 WO 2005/090578 WO 2005/000007 WO 2002/099385 WO 2002/061043 Botrytis resistance WO 2006/046861 WO 2002/085105 Bremia resistance US 20070022496 WO 2000/063432 WO 2004/049786 WO2009/111627 WO2009/111627 Erwinia resistance WO 2004/049786 Closterovirus resistance WO 2007/073167 WO 2007/053015 WO 2002/022836 Stress tolerance WO 2010/019838 (including WO 2009/049110 drought tolerance) WO2008/002480 WO2005/033318 WO2008/002480 WO2008/005210 WO2008/006033 WO2008/008779 WO2008/022486 WO2008/025097 WO2008/027534 WO2008/027540 WO2008/037902 WO2008/046069 WO2008/053487 WO2008/057642 WO2008/061240 WO2008/064222 WO2008/064341 WO2008/073617 WO2008/074025 WO2008/076844 WO2008/096138 WO2008/110848 WO2008/116829 WO2008/117537 WO2008/121320 WO2008/125245 WO2008/142034 WO2008/142036 WO2008/150165 WO2008/092935 WO2008/145675 WO2009/010460 WO2009/016240 WO2009/031664 WO2009/038581 WO2009/049110 WO2009/053511 WO2009/054735 WO2009/067580 WO2009/073605 WO2009/077611 WO2009/079508 Also yield WO2009/079529 WO2009/083958 Also yield WO2009/086229 Also yield WO2009/092009 WO2009/094401 WO2009/094527 WO2009/102965 Also biomass/ starch/oil WO2009/114733 WO2009/117448 WO2009/126359 Also grain yield WO2009/126462 WO2009/129162 WO2009/132057 WO2009/141824 WO2009/148330 WO 2010/055024 WO 2010/058428 WO 2010/064934 WO2010/076756 WO 2010/083178 WO 2010/086221 WO 2010/086277 WO 2010/101818 WO 2010/104848 WO 2010/118338 WO 2010/120017 WO 2010/120054 WO 2010/121316 WO 2010/127579 WO 2010/134654 WO 2010/139993 WO2010/039750 WO2011/034968 WO2011/001286 WO2011/017492 WO2011/018662 WO2011/024065 WO2011/038389 WO2011/46772 WO2011/053897 WO2011/052169 WO2011/063706 WO2011/067745 WO2011/079277 WO2011/080674 WO2011/083290 WO2011/083298 WO2011/091764 WO2011/052169 WO2011/053897 WO2011/056769 WO2011/063706 WO2011/067745 WO2011/083290 WO2011/083298 WO2011/091764 WO2011/096609 WO2011/122761 WO2012176167 WO2012139532 WO2012159196 WO2012162193 WO2012167023 WO2012172556 WO2012116396 Tobamovirus resistance WO 2006/038794 WO2009086850 Yield WO 2010/046221 NUE WO 2010/046471 WO 2010/049897 WO 2010/055837 WO 2010/065867 ABST WO2010/069847 WO2010/075143 WO2010/075243 WO 2010/100595 WO 2010/102220 NUE WO 2010/104092 WO 2010/108836 WO 2010/120862 ABST WO 2010/123667 WO 2010/124953 WO 2010/125036 WO 2010/127969 WO 2010/129501 WO 2010/140388 WO 2010/140672 WO2011/011273 WO2011/000466 WO2011/003800 WO2011/006717 WO2011/008510 WO2011/009801 WO2011/011412 WO2011/015985 WO2011/020746 WO2011/021190 WO2011/025514 WO2011/025515 WO2011/025516 WO2011/025840 WO2011/031680 WO2011/036160 WO2011/036232 WO2011/041796 WO2011/044254 WO2011/048009 WO2011/053898 WO2011/051120 WO2011/058029 WO2011/061656 WO2011/085062 WO2011/088065 WO2011/053898 WO2011/058029 WO2011/061656 WO2011/085062 WO2011/088065 WO2011/095958 WO2011/097215 WO2011/099006 WO2011/104128 WO2011/104141 WO2011/104143 WO2011/104155 WO2011/106734 WO2011/106794 WO2011/109661 WO2011/114279 WO2011/114305 WO2011/114312 WO2011/114313 WO2011/117800 WO2011/135527 WO2011/136909 WO2011/139431 WO2011/140329 WO2011/146754 WO2011/147826 WO2011/157976 WO2011/161617 WO2011/161620 WO2011/109618 WO2011/159452 WO2012078949 WO2012083219 WO2012084742 WO2012084756 WO2012087903 WO2012087940 WO2012090500 WO2012091939 WO2012092106 WO2012092327 WO2012092573 WO2012092580 WO2012092596 WO2012093032 WO2012093833 WO2012097720 WO2012098517 WO2012102999 WO2012106321 WO2012158630 WO2012165678 WO2012112518 WO2012117324 WO2012117330 WO2012117368 WO2012119152 WO2012142106 WO2012142116 WO2012143830 WO2012143865 WO2012145269 WO2012148121 WO2012148122 WO2012148835 WO2012150598 WO2012153267 WO2012153277 WO2012156865 WO2012158926 Oil content/ WO 2010/045324 composition WO 2010/053541 WO 2010/130725 WO 2010/140682 WO2011/006948 WO2011/049627 WO2011/060946 W02011/062748 WO2011/064181 WO2011/064183 WO2011/075716 WO2011/079005 WO2011/049627 W02011/062748 WO2011/064181 WO2011/064183 WO2011/079005 WO2011/146524 WO2011/161093 WO2011/163557 WO2011/163632 WO2011/163632 WO2012074385 WO2012074386 WO2012103452 WO2012117256 Biopharmaceutical WO 2010/121818 production WO2011/119115 Improved recombination WO2010/071418 WO 2010/133616 plant appearance WO 2010/069004 WO2011/060552 Disease control (other) WO 2010/059558 fungi WO2010/075352 Insects/non-Bt WO2010/075498 insects/Bt WO 2010/085289 insects/Bt WO 2010/085295 insects/Bt WO 2010/085373 insects/Bt WO2009/000736 fungi WO2009/065863 fungi WO2009/112505 fungi WO 2010/089374 bacteria WO 2010/120452 insects/Bt WO 2010/123904 virus WO 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No. 20080052798 Protox-inhibitor WO2011/022470 WO2011/034936 WO2011/028832 WO2011/028833 WO2011/028836 WO2011/068567 HPPD-inhibitor WO2011/076345 HPPD-inhibitor WO2011/085221 HPPD-inhibitor WO2011/094199 WO2011/094205 HPPD-inhibitor WO2011/068567 HPPD-inhibitor WO2011/085221 saflufenacil WO2011/094199 HPPD-inhibitor WO2011/094205 HPPD-inhibitor WO2011/145015 HPPD-inhibitor WO2012047595 2,4-D WO2012048124 ACCase-inhibotor WO2012048136 Glyphosate WO2012048807 Glyphosate WO2012049663 Glyphosate WO2012050962 Glyphosate WO2012056401 HPPD-inhibitor WO2012057466 PPX WO2012057465 Protox-inhibitor WO2012058223 ALS/SU WO2012115968 ,4-D WO2012148818 2,4-D WO2012148820 2,4-D WO2012106321 ACC-ase WO2012124808 Dicamba WO2012148275 Glyphosate plant metabolism WO2011/060920 WO2011/119115 WO2011/102394 reproduction/pollination WO2011/113839 control WO2012142311 WO2012163389 Biofuels WO2012073493 Fruit ripening WO2012073494 Fiber quality WO2012074386 Carbohydrates WO2012115697 WO2012132348 WO2012134906 WO2012174462

Additional particularly useful plants containing single transformation events or combinations of transformation events are listed for example in the databases from various national or regional regulatory agencies (see for example http://gmoinfo.jrc.it/gmp_browse.aspx and http://www.cera-gmc.org/?action=gm_crop_database).

Particularly useful transgenic plants which may be treated according to the invention are plants containing transformation events, or a combination of transformation events, and that are listed for example in the databases for various national or regional regulatory agencies including Event 531/PV-GHBK04 (cotton, insect control, described in WO 2002/040677), Event 1143-14A (cotton, insect control, not deposited, described in WO 06/128569); Event 1143-51B (cotton, insect control, not deposited, described in WO 06/128570); Event 1445 (cotton, herbicide tolerance, not deposited, described in US-A 2002-120964 or WO 02/034946Event 17053 (rice, herbicide tolerance, deposited as PTA-9843, described in WO 10/117737); Event 17314 (rice, herbicide tolerance, deposited as PTA-9844, described in WO 10/117735); Event 281-24-236 (cotton, insect control—herbicide tolerance, deposited as PTA-6233, described in WO 05/103266 or US-A 2005-216969); Event 3006-210-23 (cotton, insect control—herbicide tolerance, deposited as PTA-6233, described in US-A 2007-143876 or WO 05/103266); Event 3272 (corn, quality trait, deposited as PTA-9972, described in WO 06/098952 or US-A 2006-230473); Event 33391 (wheat, herbicide tolerance, deposited as PTA-2347, described in WO 2002/027004), Event 40416 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-11508, described in WO 11/075593); Event 43A47 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-11509, described in WO 11/075595); Event 5307 (corn, insect control, deposited as ATCC PTA-9561, described in WO 10/077816); Event ASR-368 (bent grass, herbicide tolerance, deposited as ATCC PTA-4816, described in US-A 2006-162007 or WO 04/053062); Event B16 (corn, herbicide tolerance, not deposited, described in US-A 2003-126634); Event BPS-CV127-9 (soybean, herbicide tolerance, deposited as NCIMB No. 41603, described in WO 10/080829); Event BLR1 (oilseed rape, restoration of male sterility, deposited as NCIMB 41193, described in WO 2005/074671), Event CE43-67B (cotton, insect control, deposited as DSM ACC2724, described in US-A 2009-217423 or WO 06/128573); Event CE44-69D (cotton, insect control, not deposited, described in US-A 2010-0024077); Event CE44-69D (cotton, insect control, not deposited, described in WO 06/128571); Event CE46-02A (cotton, insect control, not deposited, described in WO 06/128572); Event COT102 (cotton, insect control, not deposited, described in US-A 2006-130175 or WO 04/039986); Event COT202 (cotton, insect control, not deposited, described in US-A 2007-067868 or WO 05/054479); Event COT203 (cotton, insect control, not deposited, described in WO 05/054480); Event DAS21606-3/1606 (soybean, herbicide tolerance, deposited as PTA-11028, described in WO 012/033794), Event DAS40278 (corn, herbicide tolerance, deposited as ATCC PTA-10244, described in WO 11/022469); Event DAS-44406-6/pDAB8264.44.06.1 (soybean, herbicide tolerance, deposited as PTA-11336, described in WO 2012/075426), Event DAS-14536-7/pDAB8291.45.36.2 (soybean, herbicide tolerance, deposited as PTA-11335, described in WO 2012/075429), Event DAS-59122-7 (corn, insect control—herbicide tolerance, deposited as ATCC PTA 11384, described in US-A 2006-070139); Event DAS-59132 (corn, insect control—herbicide tolerance, not deposited, described in WO 09/100188); Event DAS68416 (soybean, herbicide tolerance, deposited as ATCC PTA-10442, described in WO 11/066384 or WO 11/066360); Event DP-098140-6 (corn, herbicide tolerance, deposited as ATCC PTA-8296, described in US-A 2009-137395 or WO 08/112019); Event DP-305423-1 (soybean, quality trait, not deposited, described in US-A 2008-312082 or WO 08/054747); Event DP-32138-1 (corn, hybridization system, deposited as ATCC PTA-9158, described in US-A 2009-0210970 or WO 09/103049); Event DP-356043-5 (soybean, herbicide tolerance, deposited as ATCC PTA-8287, described in US-A 2010-0184079 or WO 08/002872); Event EE-1 (brinjal, insect control, not deposited, described in WO 07/091277); Event FI117 (corn, herbicide tolerance, deposited as ATCC 209031, described in US-A 2006-059581 or WO 98/044140); Event FG72 (soybean, herbicide tolerance, deposited as PTA-11041, described in WO 2011/063413), Event GA21 (corn, herbicide tolerance, deposited as ATCC 209033, described in US-A 2005-086719 or WO 98/044140); Event GG25 (corn, herbicide tolerance, deposited as ATCC 209032, described in US-A 2005-188434 or WO 98/044140); Event GHB119 (cotton, insect control—herbicide tolerance, deposited as ATCC PTA-8398, described in WO 08/151780); Event GHB614 (cotton, herbicide tolerance, deposited as ATCC PTA-6878, described in US-A 2010-050282 or WO 07/017186); Event GJ11 (corn, herbicide tolerance, deposited as ATCC 209030, described in US-A 2005-188434 or WO 98/044140); Event GM RZ13 (sugar beet, virus resistance, deposited as NCIMB-41601, described in WO 10/076212); Event H7-1 (sugar beet, herbicide tolerance, deposited as NCIMB 41158 or NCIMB 41159, described in US-A 2004-172669 or WO 04/074492); Event JOPLIN1 (wheat, disease tolerance, not deposited, described in US-A 2008-064032); Event LL27 (soybean, herbicide tolerance, deposited as NCIMB41658, described in WO 06/108674 or US-A 2008-320616); Event LL55 (soybean, herbicide tolerance, deposited as NCIMB 41660, described in WO 06/108675 or US-A 2008-196127); Event LLcotton25 (cotton, herbicide tolerance, deposited as ATCC PTA-3343, described in WO 03/013224 or US-A 2003-097687); Event LLRICE06 (rice, herbicide tolerance, deposited as ATCC 203353, described in U.S. Pat. No. 6,468,747 or WO 00/026345); Event LLRice62 (rice, herbicide tolerance, deposited as ATCC 203352, described in WO 2000/026345), Event LLRICE601 (rice, herbicide tolerance, deposited as ATCC PTA-2600, described in US-A 2008-2289060 or WO 00/026356); Event LY038 (corn, quality trait, deposited as ATCC PTA-5623, described in US-A 2007-028322 or WO 05/061720); Event MIR162 (corn, insect control, deposited as PTA-8166, described in US-A 2009-300784 or WO 07/142840); Event MIR604 (corn, insect control, not deposited, described in US-A 2008-167456 or WO 05/103301); Event MON15985 (cotton, insect control, deposited as ATCC PTA-2516, described in US-A 2004-250317 or WO 02/100163); Event MON810 (corn, insect control, not deposited, described in US-A 2002-102582); Event MON863 (corn, insect control, deposited as ATCC PTA-2605, described in WO 04/011601 or US-A 2006-095986); Event MON87427 (corn, pollination control, deposited as ATCC PTA-7899, described in WO 11/062904); Event MON87460 (corn, stress tolerance, deposited as ATCC PTA-8910, described in WO 09/111263 or US-A 2011-0138504); Event MON87701 (soybean, insect control, deposited as ATCC PTA-8194, described in US-A 2009-130071 or WO 09/064652); Event MON87705 (soybean, quality trait—herbicide tolerance, deposited as ATCC PTA-9241, described in US-A 2010-0080887 or WO 10/037016); Event MON87708 (soybean, herbicide tolerance, deposited as ATCC PTA-9670, described in WO 11/034704); Event MON87712 (soybean, yield, deposited as PTA-10296, described in WO 2012/051199), Event MON87754 (soybean, quality trait, deposited as ATCC PTA-9385, described in WO 10/024976); Event MON87769 (soybean, quality trait, deposited as ATCC PTA-8911, described in US-A 2011-0067141 or WO 09/102873); Event MON88017 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-5582, described in US-A 2008-028482 or WO 05/059103); Event MON88913 (cotton, herbicide tolerance, deposited as ATCC PTA-4854, described in WO 04/072235 or US-A 2006-059590); Event MON88302 (oilseed rape, herbicide tolerance, deposited as PTA-10955, described in WO 2011/153186), Event MON88701 (cotton, herbicide tolerance, deposited as PTA-11754, described in WO 2012/134808), Event MON89034 (corn, insect control, deposited as ATCC PTA-7455, described in WO 07/140256 or US-A 2008-260932); Event MON89788 (soybean, herbicide tolerance, deposited as ATCC PTA-6708, described in US-A 2006-282915 or WO 06/130436); Event MS11 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-850 or PTA-2485, described in WO 01/031042); Event MS8 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or US-A 2003-188347); Event NK603 (corn, herbicide tolerance, deposited as ATCC PTA-2478, described in US-A 2007-292854); Event PE-7 (rice, insect control, not deposited, described in WO 08/114282); Event RF3 (oilseed rape, pollination control—herbicide tolerance, deposited as ATCC PTA-730, described in WO 01/041558 or US-A 2003-188347); Event RT73 (oilseed rape, herbicide tolerance, not deposited, described in WO 02/036831 or US-A 2008-070260); Event SYHT0H2/SYN-000H2-5 (soybean, herbicide tolerance, deposited as PTA-11226, described in WO 2012/082548), Event T227-1 (sugar beet, herbicide tolerance, not deposited, described in WO 02/44407 or US-A 2009-265817); Event T25 (corn, herbicide tolerance, not deposited, described in US-A 2001-029014 or WO 01/051654); Event T304-40 (cotton, insect control—herbicide tolerance, deposited as ATCC PTA-8171, described in US-A 2010-077501 or WO 08/122406); Event T342-142 (cotton, insect control, not deposited, described in WO 06/128568); Event TC1507 (corn, insect control—herbicide tolerance, not deposited, described in US-A 2005-039226 or WO 04/099447); Event VIP1034 (corn, insect control—herbicide tolerance, deposited as ATCC PTA-3925, described in WO 03/052073), Event 32316 (corn, insect control-herbicide tolerance, deposited as PTA-11507, described in WO 11/084632), Event 4114 (corn, insect control-herbicide tolerance, deposited as PTA-11506, described in WO 11/084621), EE-GM3/FG72 (soybean, herbicide tolerance, ATCC Accession N^(o) PTA-11041, WO 2011/063413A2), event DAS-68416-4 (soybean, herbicide tolerance, ATCC Accession N^(o) PTA-10442, WO2 011/066360A1), event DAS-68416-4 (soybean, herbicide tolerance, ATCC Accession N^(o) PTA-10442, WO 2011/066384A1), event DP-040416-8 (corn, insect control, ATCC Accession N^(o) PTA-11508, WO 2011/075593A1), event DP-043A47-3 (corn, insect control, ATCC Accession N^(o) PTA-11509, WO 2011/075595A1), event DP-004114-3 (corn, insect control, ATCC Accession N^(o) PTA-11506, WO 2011/084621A1), event DP-032316-8 (corn, insect control, ATCC Accession N^(o) PTA-11507, WO 2011/084632A1), event MON-88302-9 (oilseed rape, herbicide tolerance, ATCC Accession N^(o) PTA-10955, WO 2011/153186A1), event DAS-21606-3 (soybean, herbicide tolerance, ATCC Accession No. PTA-11028, WO 2012/033794A2), event MON-87712-4 (soybean, quality trait, ATCC Accession N^(o). PTA-10296, WO 2012/051199A2), event DAS-44406-6 (soybean, stacked herbicide tolerance, ATCC Accession N^(o). PTA-11336, WO 2012/075426A1), event DAS-14536-7 (soybean, stacked herbicide tolerance, ATCC Accession N^(o). PTA-11335, WO 2012/075429A1), event SYN-000H2-5 (soybean, herbicide tolerance, ATCC Accession N^(o). PTA-11226, WO 2012/082548A2), event DP-061061-7 (oilseed rape, herbicide tolerance, no deposit N^(o) available, WO 2012071039A1), event DP-073496-4 (oilseed rape, herbicide tolerance, no deposit N^(o) available, US2012131692), event 8264.44.06.1 (soybean, stacked herbicide tolerance, Accession N^(o) PTA-11336, WO 2012075426A2), event 8291.45.36.2 (soybean, stacked herbicide tolerance, Accession N^(o). PTA-11335, WO 2012075429A2), event SYHT0H2 (soybean, ATCC Accession N^(o). PTA-11226, WO 2012/082548A2), event MON88701 (cotton, ATCC Accession N^(o) PTA-11754, WO 2012/134808A1), event KK179-2 (alfalfa, ATCC Accession N^(o) PTA-11833, WO2013003558A1), event pDAB8264.42.32.1 (soybean, stacked herbicide tolerance, ATCC Accession N^(o) PTA-11993, WO 2013010094A1), event MZDT09Y (corn, ATCC Accession N^(o) PTA-13025, WO 2013012775A1), event KK179-2 (alfalfa, ATCC Accession N^(o) PTA-11833), WO2013003558A1, event pDAB8264.42.32.1 (soybean, stacked herbicide tolerance, ATCC Accession N^(o) PTA-1 1993), WO2013010094A1, event MZDT09Y (corn, ATCC Accession N^(o) PTA-13025), WO2013012775A1, event VCO-01981-5 (corn, herbicide tolerance, NCIMB Accession N^(o) 41842), WO2013014241A1, event DAS-81419-2 X DAS-68416-4 (soybean stacked insect resistance and herbicide tolerance, ATCC Accession N^(o) PTA-10442), WO2013016516A1, event DAS-81419-2 (soybean stacked insect resistance and herbicide tolerance, ATCC Accession N^(o) PTA-12006), WO2013016527A1, event HCEM485 (corn, herbicide tolerance, ATCC Accession N^(o) PTA-12014), WO2013025400A1, event pDAB4468.18.07.1 (cotton, herbicide tolerance, ATCC Accession N^(o) PTA-12456), WO2013112525A2, event pDAB4468.19.10.3 (cotton, herbicide tolerance, ATCC Accession N^(o) PTA-12457), WO2013112527A1.

In an advantageous embodiment, the compounds of the formula (I) are used for treating transgenic plants comprising at least one gene or gene fragment coding for a Bt toxin or Vip-related toxin.

Preferably, the compounds of the formula (I) are used for treating transgenic plants comprising at least one gene or gene fragment coding for a Bt toxin. A Bt toxin is a protein originating from or derived from the soil bacterium Bacillus thuringiensis which either belongs to the group of the crystal toxins (Cry) or the cytolytic toxins (Cyt). In the bacterium, they are originally formed as protoxins and are only metabolized in alkaline medium—for example in the digestive tract of certain feed insects—to their active form. There, the active toxin then binds to certain hydrocarbon structures at cell surfaces causing pores to be formed which destroy the osmotic potential of the cell, which may effect cell lysis. The result is the death of the insects. Bt toxins are active in particular against certain harmful species from the orders of the Lepidoptera (butterflies), Homoptera, Diptera and Coleoptera (beetles) in all their development stages; i.e. from the egg larva via their juvenile forms to their adult forms.

It has been known for a long time that gene sequences coding for Bt toxins, parts thereof or else peptides or proteins derived from Bt toxins can be cloned with the aid of genetic engineering into agriculturally useful plants to generate transgenic plants having endogenous resistance to pests sensitive to Bt toxins. For the purpose of the invention, the transgenic plants coding for at least one Bt toxin or proteins derived therefrom are defined as “Bt plants”.

The “first generation” of such Bt plants generally only comprise the genes enabling the formation of a certain toxin, thus only providing resistance to one group of pathogens. An example of a commercially available maize variety comprising the gene for forming the Cry1Ab toxin is “YieldGard®” from Monsanto which is resistant to the European corn borer. In contrast, in the Bt cotton variety (Bollgard®), resistance to other pathogens from the family of the Lepidoptera is generated by introduction by cloning of the genes for forming the Cry1Ac toxin. Other transgenic crop plants, in turn, express genes for forming Bt toxins with activity against pathogens from the order of the Coleoptera. Examples that may be mentioned are the Bt potato variety “NewLeaf®” (Monsanto) capable of forming the Cry3A toxin, which is thus resistant to the Colorado potato beetle, and the transgenic maize variety “YieldGard®” (Monsanto) which is capable of forming the Cry 3Bb1 toxin and is thus protected against various species of the Western corn rootworm.

In a “second generation”, the multiply transgenic plants, already described above, expressing or comprising at least two foreign genes were generated.

Preference according to the invention is given to transgenic plants with Bt toxins from the group of the Cry family (see, for example, http://www.lifesci.susx.ac.uk/home/Neil_Crickmore/Bt/.

Preferred are transgenic plants with Bt toxins from the group of the

NCBI Source Name Acc No. Protein NCBI Nuc Authors Year Strain Comment Cry1Aa1 AAA22353 142765 142764 Schnepf et al 1985 Bt kurstaki HD1 Cry1Aa2 AAA22552 551713 143100 Shibano et al 1985 Bt sotto Cry1Aa3 BAA00257 216284 216283 Shimizu et al 1988 Bt aizawai IPL7 Cry1Aa4 CAA31886 40267 40266 Masson et al 1989 Bt entomocidus Cry1Aa5 BAA04468 535781 506190 Udayasuriyan et 1994 Bt Fu-2-7 al Cry1Aa6 AAA86265 1171233 1171232 Masson et al 1994 Bt kurstaki NRD-12 Cry1Aa7 AAD46139 5669035 5669034 Osman et al 1999 Bt C12 Cry1Aa8 I26149 Liu 1996 DNA sequence only Cry1Aa9 BAA77213 4666284 4666283 Nagamatsu et al 1999 Bt dendrolimus T84A1 Cry1Aa10 AAD55382 5901703 5901702 Hou and Chen 1999 Bt kurstaki HD-1-02 Cry1Aa11 CAA70856 6687073 6687072 Tounsi et al 1999 Bt kurstaki Cry1Aa12 AAP80146 32344731 32344730 Yao et al 2001 Bt Ly30 Cry1Aa13 AAM44305 21239436 21239435 Zhong et al 2002 Bt sotto Cry1Aa14 AAP40639 37781497 37781496 Ren et al 2002 unpublished Cry1Aa15 AAY66993 67089177 67089176 Sauka et al 2005 Bt INTA Mol-12 Cry1Aa16 HQ439776 Liu et al 2010 Bt Ps9-E2 No NCBI link June 13 Cry1Aa17 HQ439788 Liu et al 2010 Bt PS9-C12 No NCBI link June 13 Cry1Aa18 HQ439790 Liu et al 2010 Bt PS9-D12 No NCBI link June 13 Cry1Aa19 HQ685121 337732098 337732097 Li & Luo 2011 Bt LS-R-21 Cry1Aa20 JF340156 Kumari & Kaur 2011 Bt SK-798 Cry1Aa21 JN651496 Li Yuhong 2011 Bt LTS-209 No NCBI link June 13 Cry1Aa22 KC158223 El Khoury et al 2013 Bt Lip Cry1Ab1 AAA22330 142720 142719 Wabiko et al 1986 Bt berliner 1715 Cry1Ab2 AAA22613 143227 143226 Thorne et al 1986 Bt kurstaki Cry1Ab3 AAA22561 143124 143123 Geiser et al 1986 Bt kurstaki HD1 Cry1Ab4 BAA00071 216280 216279 Kondo et al 1987 Bt kurstaki HD1 Cry1Ab5 CAA28405 40255 40254 Hofte et al 1986 Bt berliner 1715 Cry1Ab6 AAA22420 142886 142885 Hefford et al 1987 Bt kurstaki NRD-12 Cry1Ab7 CAA31620 40278 40277 Haider & Ellar 1988 Bt aizawai IC1 Cry1Ab8 AAA22551 143099 143098 Oeda et al 1987 Bt aizawai IPL7 Cry1Ab9 CAA38701 40273 40272 Chak & Jen 1993 Bt aizawai HD133 Cry1Ab10 A29125 Fischhoff et al 1987 Bt kurstaki HD1 Cry1Ab11 I12419 Ely & Tippett 1995 Bt A20 DNA sequence only Cry1Ab12 AAC64003 3746545 3746544 Silva-Werneck 1998 Bt kurstaki et al S93 Cry1Ab13 AAN76494 25990352 25990351 Tan et al 2002 Bt c005 Cry1Ab14 AAG16877 10440886 10440885 Meza-Basso & 2000 Native Theoduloz Chilean Bt Cry1Ab15 AAO13302 27436100 27436098 Li et al 2001 Bt B-Hm-16 Cry1Ab16 AAK55546 14190061 14190060 Yu et al 2002 Bt AC-11 Cry1Ab17 AAT46415 48734426 48734425 Huang et al 2004 Bt WB9 Cry1Ab18 AAQ88259 37048803 37048802 Stobdan et al 2004 Bt Cry1Ab19 AAW31761 56900936 56900935 Zhong et al 2005 Bt X-2 Cry1Ab20 ABB72460 82395049 82395048 Liu et al 2006 BtC008 Cry1Ab21 ABS18384 151655610 151655609 Swiecicka et al 2007 Bt IS5056 Cry1Ab22 ABW87320 159024156 159024155 Wu and Feng 2008 BtS2491Ab Cry1Ab23 HQ439777 Liu et al 2010 Bt N32-2-2 No NCBI link June 13 Cry1Ab24 HQ439778 Liu et al 2010 Bt HD12 No NCBI link June 13 Cry1Ab25 HQ685122 337732100 337732099 Li & Luo 2011 Bt LS-R-30 Cry1Ab26 HQ847729 320090245 320090244 Prathap Reddy et 2011 DOR BT-1 al Cry1Ab27 JN135249 Ammouneh et al 2011 Cry1Ab28 JN135250 Ammouneh et al 2011 Cry1Ab29 JN135251 Ammouneh et al 2011 Cry1Ab30 JN135252 Ammouneh et al 2011 Cry1Ab31 JN135253 Ammouneh et al 2011 Cry1Ab32 JN135254 Ammouneh et al 2011 Cry1Ab33 AAS93798 Li et al 2012 Bt kenyae K3 partial cds Cry1Ab34 KC156668 Sampson et al 2012 No NCBI link June 13 Cry1Ab- AAK14336 13173238 13173237 Nagarathinam et 2001 Bt kunthala uncertain like al RX24 sequence Cry1Ab- AAK14337 13173240 13173239 Nagarathinam et 2001 Bt kunthala uncertain like al RX28 sequence Cry1Ab- AAK14338 13173242 13173241 Nagarathinam et 2001 Bt kunthala uncertain like al RX27 sequence Cry1Ab- ABG88858 110734449 110734448 Lin et al 2006 Bt ly4a3 insufficient like sequence Cry1Ac1 AAA22331 Adang et al 1985 Bt kurstaki HD73 Cry1Ac2 AAA22338 Von Tersch et al 1991 Bt kenyae Cry1Ac3 CAA38098 Dardenne et al 1990 Bt BTS89A Cry1Ac4 AAA73077 Feitelson 1991 Bt kurstaki PS85A1 Cry1Ac5 AAA22339 Feitelson 1992 Bt kurstaki PS81GG Cry1Ac6 AAA86266 Masson et al 1994 Bt kurstaki NRD-12 Cry1Ac7 AAB46989 Herrera et al 1994 Bt kurstaki HD73 Cry1Ac8 AAC44841 Omolo et al 1997 Bt kurstaki HD73 Cry1Ac9 AAB49768 Gleave et al 1992 Bt DSIR732 Cry1Ac10 CAA05505 Sun 1997 Bt kurstaki YBT-1520 Cry1Ac11 CAA10270 Makhdoom & 1998 Riazuddin Cry1Ac12 I12418 Ely & Tippett 1995 Bt A20 DNA sequence only Cry1Ac13 AAD38701 Qiao et al 1999 Bt kurstaki HD1 Cry1Ac14 AAQ06607 Yao et al 2002 Bt Ly30 Cry1Ac15 AAN07788 Tzeng et al 2001 Bt from Taiwan Cry1Ac16 AAU87037 Zhao et al 2005 Bt H3 Cry1Ac17 AAX18704 Hire et al 2005 Bt kenyae HD549 Cry1Ac18 AAY88347 Kaur & Allam 2005 Bt SK-729 Cry1Ac19 ABD37053 Gao et al 2005 Bt C-33 Cry1Ac20 ABB89046 Tan et al 2005 Cry1Ac21 AAY66992 Sauka et al 2005 INTA Mol-12 Cry1Ac22 ABZ01836 Zhang & Fang 2008 Bt W015-1 Cry1Ac23 CAQ30431 Kashyap et al 2008 Bt Cry1Ac24 ABL01535 Arango et al 2008 Bt 146-158- 01 Cry1Ac25 FJ513324 237688242 237688241 Guan et al 2011 Bt Tm37-6 Cry1Ac26 FJ617446 256003038 256003037 Guan et al 2011 Bt Tm41-4 Cry1Ac27 FJ617447 256003040 256003039 Guan et al 2011 Bt Tm44-1B Cry1Ac28 ACM90319 Li et al 2009 Bt Q-12 Cry1Ac29 DQ438941 Diego Sauka 2009 INTA TA24-6 Cry1Ac30 GQ227507 Zhang et al 2010 Bt S1478-1 Cry1Ac31 GU446674 319433505 Zhao et al 2010 Bt S3299-1 Cry1Ac32 HM061081 Lu et al 2010 Bt ZQ-89 Cry1Ac33 GQ866913 306977639 306977638 Kaur & Meena 2011 Bt SK-711 Cry1Ac34 HQ230364 314906994 Kaur & Kumari 2010 Bt SK-783 Cry1Ac35 JF340157 Kumari & Kaur 2011 Bt SK-784 Cry1Ac36 JN387137 Kumari & Kaur 2011 Bt SK-958 Cry1Ac37 JQ317685 Kumari & Kaur 2011 Bt SK-793 Cry1Ac38 ACC86135 Lin et al 2008 Bt LSZ9408 Cry1Ad1 AAA22340 Feitelson 1993 Bt aizawai PS81I Cry1Ad2 CAA01880 Anonymous 1995 Bt PS81RR1 Cry1Ae1 AAA22410 Lee & Aronson 1991 Bt alesti Cry1Af1 AAB82749 Kang et al 1997 Bt NT0423 Cry1Ag1 AAD46137 Mustafa 1999 Cry1Ah1 AAQ14326 Tan et al 2000 Cry1Ah2 ABB76664 Qi et al 2005 Bt alesti Cry1Ah3 HQ439779 Liu et al 2010 Bt S6 No NCBI link June 13 Cry1Ai1 AAO39719 Wang et al 2002 Cry1Ai2 HQ439780 Liu et al 2010 Bt SC6H8 No NCBI link June 13 Cry1A- AAK14339 Nagarathinam et 2001 Bt kunthala uncertain like al nags3 sequence Cry1Ba1 CAA29898 Brizzard & 1988 Bt Whiteley thuringiensis HD2 Cry1Ba2 CAA65003 Soetaert 1996 Bt entomocidus HD110 Cry1Ba3 AAK63251 Zhang et al 2001 Cry1Ba4 AAK51084 Nathan et al 2001 Bt entomocidus HD9 Cry1Ba5 ABO20894 Song et al 2007 Bt sfw-12 Cry1Ba6 ABL60921 Martins et al 2006 Bt S601 Cry1Ba7 HQ439781 Liu et al 2010 Bt N17-37 No NCBI link June 13 Cry1Bb1 AAA22344 Donovan et al 1994 Bt EG5847 Cry1Bb2 HQ439782 Liu et al 2010 Bt WBT-2 No NCBI link June 13 Cry1Bc1 CAA86568 Bishop et al 1994 Bt morrisoni Cry1Bd1 AAD10292 Kuo et al 2000 Bt wuhanensis HD525 Cry1Bd2 AAM93496 Isakova et al 2002 Bt 834 Cry1Be1 AAC32850 Payne et al 1998 Bt PS158C2 Cry1Be2 AAQ52387 Baum et al 2003 Cry1Be3 ACV96720 259156864 Sun et al 2010 Bt g9 Cry1Be4 HM070026 Shu et al 2010 No NCBI link June 13 Cry1Bf1 CAC50778 Arnaut et al 2001 Cry1Bf2 AAQ52380 Baum et al 2003 Cry1Bg1 AAO39720 Wang et al 2002 Cry1Bh1 HQ589331 315076091 Lira et al 2010 Bt PS46L Cry1Bi1 KC156700 Sampson et al 2012 No NCBI link June 13 Cry1Ca1 CAA30396 Honee et al 1988 Bt entomocidus 60.5 Cry1Ca2 CAA31951 Sanchis et al 1989 Bt aizawai 7.29 Cry1Ca3 AAA22343 Feitelson 1993 Bt aizawai PS81I Cry1Ca4 CAA01886 Van Mellaert et 1990 Bt al entomocidus HD110 Cry1Ca5 CAA65457 Strizhov 1996 Bt aizawai 7.29 Cry1Ca6 AAF37224 Yu et al 2000 Bt AF-2 [1] Cry1Ca7 AAG50438 Aixing et al 2000 Bt J8 Cry1Ca8 AAM00264 Chen et al 2001 Bt c002 Cry1Ca9 AAL79362 Kao et al 2003 Bt G10-01A Cry1Ca10 AAN16462 Lin et al 2003 Bt E05-20a Cry1Ca11 AAX53094 Cai et al 2005 Bt C-33 Cry1Ca12 HM070027 Shu et al 2010 No NCBI link June 13 Cry1Ca13 HQ412621 312192962 Li & Luo 2010 Bt LB-R-78 Cry1Ca14 JN651493 Li Yuhong 2011 Bt LTS-38 No NCBI link June 13 Cry1Cb1 M97880 Kalman et al 1993 Bt galleriae DNA sequence HD29 only Cry1Cb2 AAG35409 Song et al 2000 Bt c001 Cry1Cb3 ACD50894 Huang et al 2008 Bt 087 Cry1Cb- AAX63901 Thammasittirong 2005 Bt TA476-1 insufficient like et al sequence Cry1Da1 CAA38099 Hofte et al 1990 Bt aizawai HD68 Cry1Da2 I76415 Payne & Sick 1997 DNA sequence only Cry1Da3 HQ439784 Liu et al 2010 Bt HD12 No NCBI link June 13 Cry1Db1 CAA80234 Lambert 1993 Bt BTS00349A Cry1Db2 AAK48937 Li et al 2001 Bt B-Pr-88 Cry1Dc1 ABK35074 Lertwiriyawong 2006 Bt JC291 et al Cry1Ea1 CAA37933 Visser et al 1990 Bt kenyae 4F1 Cry1Ea2 CAA39609 Bosse et al 1990 Bt kenyae Cry1Ea3 AAA22345 Feitelson 1991 Bt kenyae PS81F Cry1Ea4 AAD04732 Barboza-Corona 1998 Bt kenyae et al LBIT-147 Cry1Ea5 A15535 Botterman et al 1994 DNA sequence only Cry1Ea6 AAL50330 Sun et al 1999 Bt YBT-032 Cry1Ea7 AAW72936 Huehne et al 2005 Bt JC190 Cry1Ea8 ABX11258 Huang et al 2007 Bt HZM2 Cry1Ea9 HQ439785 Liu et al 2010 Bt S6 No NCBI link June 13 Cry1Ea10 ADR00398 Goncalves et al 2010 Bt BR64 Cry1Ea11 JQ652456 Lin Qunxin et al 2012 Bt Cry1Ea12 KF601559 Baonan He 2013 Bt strain V4 No NCBI link Sep 13 Cry1Eb1 AAA22346 Feitelson 1993 Bt aizawai PS81A2 Cry1Fa1 AAA22348 Chambers et al 1991 Bt aizawai EG6346 Cry1Fa2 AAA22347 Feitelson 1993 Bt aizawai PS81I Cry1Fa3 HM070028 Shu et al 2010 No NCBI link June 13 Cry1Fa4 HM439638 Liu et al 2010 Bt mo3-D10 No NCBI link June 13 Cry1Fb1 CAA80235 Lambert 1993 Bt BTS00349A Cry1Fb2 BAA25298 Masuda & 1998 Bt morrisoni Asano INA67 Cry1Fb3 AAF21767 Song et al 1998 Bt morrisoni Cry1Fb4 AAC10641 Payne et al 1997 Cry1Fb5 AAO13295 Li et al 2001 Bt B-Pr-88 Cry1Fb6 ACD50892 Huang et al 2008 Bt 012 Cry1Fb7 ACD50893 Huang et al 2008 Bt 087 Cry1Ga1 CAA80233 Lambert 1993 Bt BTS0349A Cry1Ga2 CAA70506 Shevelev et al 1997 Bt wuhanensis Cry1Gb1 AAD10291 Kuo & Chak 1999 Bt wuhanensis HD525 Cry1Gb2 AAO13756 Li et al 2000 Bt B-Pr-88 Cry1Gc1 AAQ52381 Baum et al 2003 Cry1Ha1 CAA80236 Lambert 1993 Bt BTS02069AA Cry1Hb1 AAA79694 Koo et al 1995 Bt morrisoni BF190 Cry1Hb2 HQ439786 Liu et al 2010 Bt WBT-2 No NCBI link June 13 Cry1H- AAF01213 Srifah et al 1999 Bt JC291 insufficient like sequence Cry1Ia1 CAA44633 Tailor et al 1992 Bt kurstaki Cry1Ia2 AAA22354 Gleave et al 1993 Bt kurstaki Cry1Ia3 AAC36999 Shin et al 1995 Bt kurstaki HD1 Cry1Ia4 AAB00958 Kostichka et al 1996 Bt AB88 Cry1Ia5 CAA70124 Selvapandiyan 1996 Bt 61 Cry1Ia6 AAC26910 Zhong et al 1998 Bt kurstaki S101 Cry1Ia7 AAM73516 Porcar et al 2000 Bt Cry1Ia8 AAK66742 Song et al 2001 Cry1Ia9 AAQ08616 Yao et al 2002 Bt Ly30 Cry1Ia10 AAP86782 Espindola et al 2003 Bt thuringiensis Cry1Ia11 CAC85964 Tounsi et al 2003 Bt kurstaki BNS3 Cry1Ia12 AAV53390 Grossi de Sa et 2005 Bt al Cry1Ia13 ABF83202 Martins et al 2006 Bt Cry1Ia14 ACG63871 Liu & Guo 2008 Bt11 Cry1Ia15 FJ617445 256003036 256003035 Guan et al 2011 Bt E-1B Cry1Ia16 FJ617448 256003042 256003041 Guan et al 2011 Bt E-1A Cry1Ia17 GU989199 Li et al 2010 Bt MX2 Cry1Ia18 ADK23801 300492624 Li et al 2010 Bt MX9 Cry1Ia19 HQ439787 Liu et al 2010 Bt SC6H6 No NCBI link June 13 Cry1Ia20 JQ228426 Zhao Can 2011 Bt wu1H-3 No NCBI link June 13 Cry1Ia21 JQ228424 Zhao Can 2011 Bt you1D-9 No NCBI link June 13 Cry1Ia22 JQ228427 Zhao Can 2011 Bt wu1E-3 No NCBI link June 13 Cry1Ia23 JQ228428 Zhao Can 2011 Bt wu1E-4 No NCBI link June 13 Cry1Ia24 JQ228429 Zhao Can 2011 Bt wu2B-6 No NCBI link June 13 Cry1Ia25 JQ228430 Zhao Can 2011 Bt wu2G-11 No NCBI link June 13 Cry1Ia26 JQ228431 Zhao Can 2011 Bt wu2G-12 No NCBI link June 13 Cry1Ia27 JQ228432 Zhao Can 2011 Bt you2D-3 No NCBI link June 13 Cry1Ia28 JQ228433 Zhao Can 2011 Bt you2E-3 No NCBI link June 13 Cry1Ia29 JQ228434 Zhao Can 2011 Bt you2F-3 No NCBI link June 13 Cry1Ia30 JQ317686 Kumari & Kaur 2011 Bt 4J4 Cry1Ia31 JX944038 Song et al 2012 Bt SC-7 Cry1Ia32 JX944039 Song et al 2012 Bt SC-13 Cry1Ia33 JX944040 Song et al 2012 Bt SC-51 Cry1Ib1 AAA82114 Shin et al 1995 Bt entomocidus BP465 Cry1Ib2 ABW88019 Guan et al 2007 Bt PP61 Cry1Ib3 ACD75515 Liu & Guo 2008 Bt GS8 Cry1Ib4 HM051227 301641366 Zhao et al 2010 Bt BF-4 Cry1Ib5 HM070028 Shu et al 2010 No NCBI link June13 Cry1Ib6 ADK38579 300836937 Li et al 2010 Bt LB52 Cry1Ib7 JN571740 Kumari & Kaur 2011 Bt SK-935 Cry1Ib8 JN675714 Swamy et al 2011 Cry1Ib9 JN675715 Swamy et al 2011 Cry1Ib10 JN675716 Swamy et al 2011 Cry1Ib11 JQ228423 Zhao Can 2011 Bt HD12 No NCBI link June 13 Cry1Ic1 AAC62933 Osman et al 1998 Bt C18 Cry1Ic2 AAE71691 Osman et al 2001 Cry1Id1 AAD44366 Choi 2000 Cry1Id2 JQ228422 Zhao Can 2011 Bt HD12 No NCBI link June 13 Cry1Ie1 AAG43526 Song et al 2000 Bt BTC007 Cry1Ie2 HM439636 Liu et al 2010 Bt T03B001 No NCBI link June 13 Cry1Ie3 KC156647 Sampson et al 2012 No NCBI link June 13 Cry1Ie4 KC156681 Sampson et al 2012 No NCBI link June 13 Cry1If1 AAQ52382 Baum et al 2003 Cry1Ig1 KC156701 Sampson et al 2012 No NCBI link June 13 Cry1I-like AAC31094 Payne et al 1998 insufficient sequence Cry1I-like ABG88859 Lin & Fang 2006 Bt 1y4a3 insufficient sequence Cry1Ja1 AAA22341 Donovan 1994 Bt EG5847 Cry1Ja2 HM070030 Shu et al 2010 No NCBI link June 13 Cry1Ja3 JQ228425 Zhao Shiyuan 2011 Bt FH21 No NCBI link June 13 Cry1Jb1 AAA98959 Von Tersch & 1994 Bt EG5092 Gonzalez Cry1Jc1 AAC31092 Payne et al 1998 Cry1Jc2 AAQ52372 Baum et al 2003 Cry1Jd1 CAC50779 Arnaut et al 2001 Bt Cry1Ka1 AAB00376 Koo et al 1995 Bt morrisoni BF190 Cry1Ka2 HQ439783 Liu et al 2010 Bt WBT-2 No NCBI link June 13 Cry1La1 AAS60191 Je et al 2004 Bt kurstaki K1 Cry1La2 HM070031 Shu et al 2010 No NCBI link June 13 Cry1Ma1 FJ884067 Noguera & 2010 LBIT 1189 Ibarra Cry1Ma2 KC156659 Sampson et al 2012 No NCBI link June 13 Cry1Na1 KC156648 Sampson et al 2012 No NCBI link June 13 Cry1Nb1 KC156678 Sampson et al 2012 No NCBI link June 13

Particular preference is given to the genes or gene sections of the subfamilies cry1, cry2, cry3, cry5 and cry9; especially preferred are members of the subfamily cry1A such as cry1Aa, cry1Ac, cry2Ab.

Furthermore, it is preferred to use plants which, in addition to the genes for one or more Bt toxins, express or contain, if appropriate, also genes for expressing, for example, a protease or peptidase inhibitor (such as in WO-A 95/35031), of herbicide resistances (for example to glufosinate or glyphosate by expression of the pat gene or bar gene) or for becoming resistant to nematodes, fungi or viruses (for example by expressing a gluconase, chitinase). However, they may also be genetically modified in their metabolic properties, so that they show a qualitative and/or quantitative change of ingredients (for example by modification of the energy, carbohydrate, fatty acid or nitrogen metabolism or by metabolite currents influencing these (see above).

In one preferred embodiment, a Bt-plant, preferably a Bt-soybean, comprises event MON87701 which is described in, e.g., WO2009/064652. Thus, in one preferred embodiment, a Bt-soybean seeds comprising said event of which a representative sample was deposited at the ATCC under Accession No. PTA-8194 are treated with a ryanodine receptor modulator according to the present invention.

In another preferred embodiment, a Bt-soybean comprises event pDAB9582.814.19.1 and/or event pDAB4468.04.16.1 which are described in, e.g., WO 2013/016516. This breeding stacks comprise cry1F, cry1Ac and pat and aad-12 and pat, as described in WO 2012/075426. Thus, in one preferred embodiment, a Bt-soybean seeds of which comprising said events were deposited at the ATCC under Accession No. PTA-10442 (pDAB4468.04.16.1) are treated with a ryanodine receptor modulator according to the present invention.

In one preferred embodiment, the method of the invention is characterized in that the Bt-plant, preferably a Bt-soybean plant, comprises at least one cry-gene or a cry-gene fragment coding for a Bt toxin.

In one preferred embodiment, said method is characterized in that the Bt-plant, preferably Bt-soybean plant, comprises at least one cry1A-gene or cry1A-gene fragment coding for a Bt toxin.

In one preferred embodiment, said method is characterized in that said Bt-plant, preferably Bt-soybean plant, further comprising a cryF gene or cryF-gene fragment coding for a Bt toxin.

In another preferred embodiment, said method is characterized in that said plant, preferably said soybean plant, comprises event MON87701.

In a more preferred embodiment, said soybean plant comprises event MON87701 and event MON89788, e.g. Intacta™ Roundup Ready™ 2 Pro.

In another preferred embodiment, said method is characterized in that said soybean plant comprising DNA that comprises a first sequence selected from the group consisting of bp 1385-1415 of SEQ ID NO: 1; bp 1350-1450 of SEQ ID NO: 1; bp 1300-1500 of SEQ ID NO: 1; bp 1200-1600 of SEQ ID NO: 1; bp 137-168 of SEQ ID NO:2; bp 103-203 of SEQ ID NO:2; and bp 3-303 of SEQ ID NO:2; and a second sequence selected from the group consisting bp 2680-2780 of SEQ ID NO: 3; bp 2630-2830 of SEQ ID NO: 15; bp 2530-2930 of SEQ ID NO: 15; bp 9071-9171 of SEQ ID NO: 15; bp 9021-9221 of SEQ ID NO: 15; and, bp 8921-9321 of SEQ ID NO: 15 said first and second sequences being diagnostic for the presence of soybean event pDAB9582.814.19.1::pDAB4468.04.16.1. pDAB9582.814.19.1::pDAB4468.04.16.1 are disclosed in WO 2013/016516.

In one preferred embodiment, said method is characterized in that said soybean plant comprising a nucleotide sequence of SEQ ID NO: 4, SEQ ID NO:5, or complement thereof.

In one preferred embodiment, said method is characterized in that said soybean plant comprising a nucleotide sequence of SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:9 or complement thereof.

In one preferred embodiment, said method is characterized in that said soybean plant comprising a nucleotide sequence of SEQ ID NO:6 from positions 1 to 5757, the nucleotide sequence of SEQ ID NO:8 from positions 1 to 6426, and the nucleotide sequence of SEQ ID NO:7 from positions 379 to 2611, or complement thereof.

In one preferred embodiment, said method is characterized in that said soybean plant comprising a nucleotide sequence essentially of the nucleotide sequence of SEQ ID NO: 9 or complement thereof.

In another preferred embodiment, said method is characterized in that said pest is selected from the group consisting of Pseudoplusia includens (soybean looper), Anticarsia gemmatalis (velvet bean caterpillar) and Spodoptera frugiperda (fall armyworm).

In another preferred embodiment, said method is characterized in that the use form of the ryanodine receptor modulator is present in a mixture with at least one mixing partner.

A second aspect refers to a method for improving the utilization of the production potential of transgenic soybean plants in the absent of a pest. Preferred embodiments of this aspect are identical to the preferred embodiments disclosed for the first aspect of the present invention.

A third aspect refers to a synergistic composition comprising Bt toxins encoded by a nucleotide sequence that comprises

-   -   a first sequence selected from the group consisting of bp         1385-1415 of SEQ ID NO: 1; bp 1350-1450 of SEQ ID NO: 1; bp         1300-1500 of SEQ ID NO: 1; bp 1200-1600 of SEQ ID NO: 1; by         137-168 of SEQ ID NO:2; bp 103-203 of SEQ ID NO:2; and bp 3-303         of SEQ ID NO:2; and a second sequence selected from the group         consisting bp 2680-2780 of SEQ ID NO: 3; bp 2630-2830 of SEQ ID         NO: 15; bp 2530-2930 of SEQ ID NO: 15; bp 9071-9171 of SEQ ID         NO: 15; bp 9021-9221 of SEQ ID NO: 15; and, bp 8921-9321 of SEQ         ID NO: 15 or     -   a nucleotide sequence of SEQ ID NO: 4, SEQ ID NO:5, or         complement thereof         and a ryanodine receptor modulator as described herein.

A fourth aspect refers to a Bt-soybean plant, characterized in that at least 0.00001 g of a ryanodine receptor modulator as described herein is attached to it.

SEQ ID No: 1 (disclosed in WO 2013/016516) is the 5′ DNA flanking border sequence for soybean event pDAB9582.814.19.1. Nucleotides 1-1400 are genomic sequence. Nucleotides 1401-1535 are a rearranged sequence from pDAB9582. Nucleotides 1536-1836 are insert sequence.

SEQ ID No: 2 (disclosed in WO 2013/016516) is the 3′ DNA flanking border sequence for soybean event pDAB9582.814.19.1. Nucleotides 1-152 are insert sequence. Nucleotides 153-1550 are genomic sequence.

SEQ ID No: 3 (disclosed in WO 2013/016516) is the confirmed sequence of soybean event pDAB4468.04.16.1. Including the 5′ genomic flanking sequence, pDAB4468 T-strand insert, and 3′ genomic flanking sequence.

SEQ ID No:4 (disclosed in WO 2009/064652) is a A 20 nucleotide sequence representing the junction between the soybean genomic DNA and an integrated expression cassette. This sequence corresponds to positions 5748 to 5767 of SEQ ID NO:9. In addition, SEQ ID NO: 1 is a nucleotide sequence corresponding to positions 5748 through 5757 of SEQ ID NO:6 and the integrated right border of the TIC 107 expression cassette corresponding to positions 1 through 10 of SEQ ID NO:8. SEQ ID NO:1 also corresponds to positions 5748 to 5767 of the 5′ flanking sequence, SEQ ID NO:6.

SEQ ID No: 5 (disclosed in WO 2009/064652) is a 20 nucleotide sequence representing the junction between an integrated expression cassette and the soybean genomic DNA. This sequence corresponds to positions 12174 to 12193 of SEQ ID NO:9. In addition, SEQ ID NO:2 is a nucleotide sequence corresponding positions 6417 through 6426 of SEQ ID NO:8 and the 3′ flanking sequence corresponding to positions 379 through 388 of SEQ ED NO:7.

SEQ ID No: 6 (disclosed in WO 2009/064652) is the 5′ sequence flanking the inserted DNA of MON87701 up to and including a region of transformation DNA (T-DNA) insertion.

SEQ ID No: 7 (disclosed in WO 2009/064652) is the 3′ sequence flanking the inserted DNA of MON87701 up to and including a region of T-DNA insertion.

SEQ ID No: 8 (disclosed in WO 2009/064652) is the sequence of the integrated TIC 107 expression cassette, including right and left border sequence after integration.

SEQ ID No: 9 (disclosed in WO 2009/064652) is a 14,416 bp nucleotide sequence representing the contig of the 5′ sequence flanking the inserted DNA of MON87701 (SEQ ID NO:6), the sequence of the integrated expression cassette (SEQ ID NO:8) and the 3′ sequence flanking the inserted DNA of MON87701 (SEQ ID NO: 7).

A nucleic acid molecule is said to be the “complement” of another nucleic acid molecule if they exhibit complete complementarity. As used herein, molecules are said to exhibit “complete complementarity” when every nucleotide of one of the molecules is complementary to a nucleotide of the other. Two molecules are said to be “minimally complementary” if they can hybridize to one another with sufficient stability to permit them to remain annealed to one another under at least conventional “low-stringency” conditions. Similarly, the molecules are said to be “complementary” if they can hybridize to one another with sufficient stability to permit them to remain annealed to one another under conventional “high-stringency” conditions. Conventional stringency conditions are described by Sambrook et al, 1989, and by Haymes et al, In: Nucleic Acid Hybridization, A Practical Approach, IRL Press, Washington, D.C. (1985), Departures from complete complementarity are therefore permissible, as long as such departures do not completely preclude the capacity of the molecules to form a double-stranded structure. In order for a nucleic acid molecule to serve as a primer or probe it need only be sufficiently complementary in sequence to be able to form a stable double-stranded structure under the particular solvent and salt concentrations employed.

As used herein, a “substantially homologous sequence” is a nucleic acid sequence that will specifically hybridize to the complement of the nucleic acid sequence to which it is being compared under high stringency conditions. Appropriate stringency conditions which promote DNA hybridization, for example, 6.0× sodium chloride/sodium citrate (SSC) at about 45<0>C, followed by a wash of 2.0×SSC at 50<0>C, are known to those skilled in the art or can be found in Current Protocols in Molecular Biology, John Wiley & Sons, N.Y. (1989), 6.3.1-6.3.6. For example, the salt concentration in the wash step can be selected from a low stringency of about 2.0×SSC at 50<0>C to a high stringency of about 0.2×SSC at 50<0>C. In addition, the temperature in the wash step can be increased from low stringency conditions at room temperature, about 22<0>C, to high stringency conditions at about 65<0>C. Both temperature and salt may be varied, or either the temperature or the salt concentration may be held constant while the other variable is changed. In a preferred embodiment, a nucleic acid of the present invention will specifically hybridize to one or more of the nucleic acid molecules set forth in SEQ ID NO: 1 and 2 or complements thereof or fragments of either under moderately stringent conditions, for example at about 2.0×SSC and about 65<0>C. In a particularly preferred embodiment, a nucleic acid of the present invention will specifically hybridize to one or more of the nucleic acid molecules set forth in SEQ ID NO: 1 and SEQ ID NO:2 or complements or fragments of either under high stringency conditions. In one aspect of the present invention, a preferred marker nucleic acid molecule of the present invention has the nucleic acid sequence set forth in SEQ ID NO:1 and SEQ ID NO:2 or complements thereof or fragments of either. In another aspect of the present invention, a preferred marker nucleic acid molecule of the present invention shares 80%, 81%, 82%, 83%, 84%, 85%, 86%, 87%, 88%, 89%, 90%, 91%, 92%, 93%, 94%, 95%, 96%, 97%, 98%, 99% and 100% sequence identity with the nucleic acid sequence set forth in SEQ ID NO:1 and SEQ ID NO:2 or complement thereof or fragments of either. In a further aspect of the present invention, a preferred marker nucleic acid molecule of the present invention shares 95% 96%, 97%, 98%, 99% and 100% sequence identity with the sequence set forth in SEQ ID NO:1 and SEQ ID NO: 2 or complement thereof or fragments of either. SEQ ID NO:1 and SEQ ID NO:2 may be used as markers in plant breeding methods to identify the progeny of genetic crosses similar to the methods described for simple sequence repeat DNA marker analysis, in “DNA markers: Protocols, applications, and overviews: (1997) 173-185, Cregan, et al., eds., Wiley-Liss NY”; all of which is herein incorporated by reference. The hybridization of the probe to the target DNA molecule can be detected by any number of methods known to those skilled in the art, these can include, but are not limited to, fluorescent tags, radioactive tags, antibody based tags, and chemilluminescent tags.

Regarding the amplification of a target nucleic acid sequence (e.g., by PCR) using a particular amplification primer pair, “stringent conditions” are conditions that permit the primer pair to hybridize only to the target nucleic-acid sequence to which a primer having the corresponding wild-type sequence (or its complement) would bind and preferably to produce a unique amplification product, the amplicon, in a DNA thermal amplification reaction.

The term “specific for (a target sequence)” indicates that a probe or primer hybridizes under stringent hybridization conditions only to the target sequence in a sample comprising the target sequence.

In a particularly preferred variant, the process according to the invention is used for treating transgenic vegetable, maize, soya bean, cotton, tobacco, rice, potato and sugar beet varieties. These are preferably Bt plants.

The vegetable plants or varieties are, for example, the following useful plants:

-   -   potatoes: preferably starch potatoes, sweet potatoes and table         potatoes;     -   root vegetables: preferably carrots, turnips (swedes, stubble         turnips (Brassica rapa var. rapa), spring turnips, autumn         turnips (Brassica campestris ssp. rapifera), Brassica rapa L.         ssp. rapa f. teltowiensis), scorzonera, Jerusalem artichoke,         turnip-rooted parsley, parsnip, radish and horseradish;     -   tuber vegetables: preferably kohlrabi, beetroot, celeriac,         garden radish;     -   bulb crops: preferably scallion, leek and onions (planting         onions and seed onions);     -   brassica vegetables: preferably headed cabbage (white cabbage,         red cabbage, kale, savoy cabbage), cauliflowers, broccoli, curly         kale, marrow-stem kale, seakale and Brussels sprouts;     -   fruiting vegetables: preferably tomatoes (outdoor tomatoes,         vine-ripened tomatoes, beef tomatoes, greenhouse tomatoes,         cocktail tomatoes, industrial and fresh market tomatoes),         melons, eggplants, aubergines, pepper (sweet pepper and hot         pepper, Spanish pepper), chilli pepper, pumpkins, courgettes and         cucumbers (outdoor cucumbers, greenhouse cucumbers snake gourds         and gherkins);     -   vegetable pulses: preferably bush beans (as sword beans, string         beans, flageolet beans, wax beans, corn beans of green- and         yellow-podded cultivars), pole beans (as sword beans, string         beans, flageolet beans, wax beans of green-, blue- and         yellow-podded cultivars), broadbeans (field beans, Windsor         beans, cultivars having white- and black-spotted flowers), peas         (chickling vetch, chickpeas, marrow peas, shelling peas,         sugar-peas, smooth peas, cultivars having light- and dark-green         fresh fruits) and lentils;     -   green vegetables and stem vegetables: preferably Chinese         cabbage, round-headed garden lettuce, curled lettuce,         lamb's-lettuce, iceberg lettuce, romaine lettuce, oakleaf         lettuce, endives, radicchio, lollo rossa, ruccola lettuce,         chicory, spinach, chard (leaf chard and stem chard) and parsley;     -   other vegetables: preferably asparagus, rhubarb, chives,         artichokes, mint varieties, sunflowers, Florence fennel, dill,         garden cress, mustard, poppy seed, peanuts, sesame and salad         chicory.

Bt vegetables including exemplary methods for preparing them are described in detail, for example, in Barton et al., 1987, Plant Physiol. 85: 1103-1109; Vaeck et al., 1987, Nature 328: 33-37; Fischhoff et al., 1987, Bio/Technology 5: 807-813. In addition, Bt vegetable plants are already known as commercial varieties, for example the potato cultivar NewLeaf® (Monsanto). The preparation of Bt vegetables is also described in U.S. Pat. No. 6,072,105.

Likewise, Bt cotton is already known in principle, for example from U.S. Pat. No. 5,322,938. In the context of the present invention, particular preference is given to Bt cotton with the trade names NuCOTN33® and NuCOTN33B®.

The use and preparation of Bt maize has likewise already been known for a long time, for example from Ishida, Y., Saito, H., Ohta, S., Hiei, Y., Komari, T., and Kumashiro, T. (1996). High efficiency transformation of maize (Zea mayz L.) mediated by Agrobacterium tumefaciens, Nature Biotechnology 4: 745-750. EP-B-0485506, too, describes the preparation of Bt maize plants. Furthermore, different varieties of Bt maize are commercially available, for example under the following names (company/companies is/are in each case given in brackets): KnockOut® (Novartis Seeds), NaturGard® (Mycogen Seeds), Yieldgard® (Novartis Seeds, Monsanto, Cargill, Golden Harvest, Pioneer, DeKalb inter alia), Bt-Xtra® (DeKalb) and StarLink® (Aventis CropScience, Garst inter alia). For the purpose of the present invention, particular preference is given especially to the following maize cultivars: KnockOut®, NaturGard®, Yieldgard®, Bt-Xtra® and StarLink®.

For soya beans, too, Roundup®Ready cultivar or cultivars resistant to the herbicide Liberty Link® are available and can be treated according to the invention. In the case of rice, a large number of “Golden Rice” lines are available which are likewise characterized in that, by virtue of a transgenic modification, they have an increased content of provitamin A. They, too, are examples of plants which can be treated by the method according to the invention, with the advantages described.

The method according to the invention is suitable for controlling a large number of harmful organisms which occur in particular in vegetables, maize and cotton, in particular insects and arachnids, very particularly preferably insects. The pests mentioned include:

-   -   From the order of the Anoplura (Phthiraptera), for example,         Damalinia spp., Haematopinus spp., Linognathus spp., Pediculus         spp., Trichodectes spp.     -   From the class of the Arachnida, for example, Acarus siro,         Aceria sheldoni, Aculops spp., Aculus spp., Amblyomma spp.,         Argas spp., Boophilus spp., Brevipalpus spp., Bryobia praetiosa,         Chorioptes spp., Dermanyssus gallinae, Eotetranychus spp.,         Epitrimerus pyri, Eutetranychus spp., Eriophyes spp.,         Hemitarsonemus spp., Hyalomma spp., Ixodes spp., Latrodectus         mactans, Metatetranychus spp., Oligonychus spp., Ornithodoros         spp., Panonychus spp., Phyllocoptruta oleivora,         Polyphagotarsonemus latus, Psoroptes spp., Rhipicephalus spp.,         Rhizoglyphus spp., Sarcoptes spp., Scorpio maurus,         Stenotarsonemus spp., Tarsonemus spp., Tetranychus spp., Vasates         lycopersici.     -   From the class of the Bivalva, for example, Dreissena spp.     -   From the order of the Chilopoda, for example, Geophilus spp.,         Scutigera spp.     -   From the order of the Coleoptera, for example, Acanthoscelides         obtectus, Adoretus spp., Agelastica alni, Agriotes spp.,         Amphimallon solstitialis, Anobium punctatum, Anoplophora spp.,         Anthonomus spp., Anthrenus spp., Apogonia spp., Atomaria spp.,         Attagenus spp., Bruchidius obtectus, Bruchus spp.,         Ceuthorhynchus spp., Cleonus mendicus, Conoderus spp.,         Cosmopolites spp., Costelytra zealandica, Curculio spp.,         Cryptorhynchus lapathi, Dermestes spp., Diabrotica spp.,         Epilachna spp., Faustinus cubae, Gibbium psylloides,         Heteronychus arator, Hylamorpha elegans, Hylotrupes bajulus,         Hypera postica, Hypothenemus spp., Lachnosterna consanguinea,         Leptinotarsa decemlineata, Lissorhoptrus oryzophilus, Lixus         spp., Lyctus spp., Meligethes aeneus, Melolontha melolontha,         Migdolus spp., Monochamus spp., Naupactus xanthographus, Niptus         hololeucus, Oryctes rhinoceros, Oryzaephilus surinamensis,         Otiorrhynchus sulcatus, Oxycetonia jucunda, Phaedon cochleariae,         Phyllophaga spp., Popillia japonica, Premno-trypes spp.,         Psylliodes chrysocephala, Ptinus spp., Rhizobius ventralis,         Rhizopertha dominica, Sitophilus spp., Sphenophorus spp.,         Sternechus spp., Symphyletes spp., Tenebrio molitor, Tribolium         spp., Trogoderma spp., Tychius spp., Xylotrechus spp., Zabrus         spp.     -   From the order of the Collembola, for example, Onychiurus         armatus.     -   From the order of the Dermaptera, for example, Forficula         auricularia.     -   From the order of the Diplopoda, for example, Blaniulus         guttulatus.     -   From the order of the Diptera, for example, Aedes spp.,         Anopheles spp., Bibio hortulanus, Calliphora erythrocephala,         Ceratitis capitata, Chrysomyia spp., Cochliomyia spp.,         Cordylobia anthropophaga, Culex spp., Cuterebra spp., Dacus         oleae, Dermatobia hominis, Drosophila spp., Fannia spp.,         Gastrophilus spp., Hylemyia spp., Hyppobosca spp., Hypo-derma         spp., Liriomyza spp. Lucilia spp., Musca spp., Nezara spp.,         Oestrus spp., Oscinella frit, Pegomyia hyoscyami, Phorbia spp.,         Stomoxys spp., Tabanus spp., Tannia spp., Tipula paludosa,         Wohlfahrtia spp.     -   From the class of the Gastropoda, for example, Anion spp.,         Biomphalaria spp., Bulinus spp., Deroceras spp., Galba spp.,         Lymnaea spp., Oncomelania spp., Succinea spp.     -   From the class of the helminths, for example, Ancylostoma         duodenale, Ancylostoma ceylanicum, Acylostoma braziliensis,         Ancylostoma spp., Ascaris lumbricoides, Ascaris spp., Brugia         malayi, Brugia timori, Bunostomum spp., Chabertia spp.,         Clonorchis spp., Cooperia spp., Dicrocoelium spp, Dictyocaulus         filaria, Diphyllobothrium latum, Dracunculus medinensis,         Echinococcus granulosus, Echinococcus multilocularis, Enterobius         vermicularis, Faciola spp., Haemonchus spp., Heterakis spp.,         Hymenolepis nana, Hyostrongulus spp., Loa Loa, Nematodirus spp.,         Oesophagostomum spp., Opisthorchis spp., Onchocerca volvulus,         Ostertagia spp., Paragonimus spp., Schistosomen spp.,         Strongyloides fuelleborni, Strongyloides stercoralis,         Stronyloides spp., Taenia saginata, Taenia solium, Trichinella         spiralis, Trichinella nativa, Trichinella britovi, Trichinella         nelsoni, Trichinella pseudopsiralis, Trichostrongulus spp.,         Trichuris trichiura, Wuchereria bancrofti.     -   It is furthermore possible to control Protozoa, such as Eimeria.     -   From the order of the Heteroptera, for example, Anasa tristis,         Antestiopsis spp., Blissus spp., Calocoris spp., Campylomma         livida, Cavelerius spp., Cimex spp., Creontiades dilutus,         Dasynus piperis, Dichelops furcatus, Diconocoris hewetti,         Dysdercus spp., Euschistus spp., Eurygaster spp., Heliopeltis         spp., Horcias nobilellus, Leptocorisa spp., Leptoglossus         phyllopus, Lygus spp., Macropes excavatus, Miridae, Nezara spp.,         Oebalus spp., Pentomidae, Piesma quadrata, Piezodorus spp.,         Psallus seriatus, Pseudacysta persea, Rhodnius spp.,         Sahlbergella singularis, Scotinophora spp., Stephanitis nashi,         Tibraca spp., Triatoma spp.     -   From the order of the Homoptera, for example, Acyrthosipon spp.,         Aeneolamia spp., Agonoscena spp., Aleurodes spp., Aleurolobus         barodensis, Aleurothrixus spp., Amrasca spp., Anuraphis cardui,         Aonidiella spp., Aphanostigma pini, Aphis spp., Arboridia         apicalis, Aspidiella spp., Aspidiotus spp., Atanus spp.,         Aulacorthum solani, Bemisia spp., Brachycaudus helichrysii,         Brachycolus spp., Brevicoryne brassicae, Calligypona marginata,         Carneocephala fulgida, Ceratovacuna lanigera, Cercopidae,         Ceroplastes spp., Chaetosiphon fragaefolii, Chionaspis         tegalensis, Chlorita onukii, Chromaphis juglandicola,         Chrysomphalus ficus, Cicadulina mbila, Coccomytilus halli,         Coccus spp., Cryptomyzus ribis, Dalbulus spp., Dialeurodes spp.,         Diaphorina spp., Diaspis spp., Doralis spp., Drosicha spp.,         Dysaphis spp., Dysmicoccus spp., Empoasca spp., Eriosoma spp.,         Erythroneura spp., Euscelis bilobatus, Geococcus coffeae,         Homalodisca coagulata, Hyalopterus arundinis, Icerya spp.,         Idiocerus spp., Idioscopus spp., Laodelphax striatellus,         Lecanium spp., Lepidosaphes spp., Lipaphis erysimi, Macrosiphum         spp., Mahanarva fimbriolata, Melanaphis sacchari, Metcalfiella         spp., Metopolophium dirhodum, Monellia costalis, Monelliopsis         pecanis, Myzus spp., Nasonovia ribisnigri, Nephotettix spp.,         Nilaparvata lugens, Oncometopia spp., Orthezia praelonga,         Parabemisia myricae, Paratrioza spp., Parlatoria spp., Pemphigus         spp., Peregrinus maidis, Phenacoccus spp., Phloeomyzus         passerinii, Phorodon humuli, Phylloxera spp., Pinnaspis         aspidistrae, Planococcus spp., Protopulvinaria pyriformis,         Pseudaulacaspis pentagona, Pseudococcus spp., Psylla spp.,         Pteromalus spp., Pyrilla spp., Quadraspidiotus spp., Quesada         gigas, Rastrococcus spp., Rhopalosiphum spp., Saissetia spp.,         Scaphoides titanus, Schizaphis graminum, Selenaspidus         articulatus, Sogata spp., Sogatella furcifera, Sogatodes spp.,         Stictocephala festina, Tenalaphara malayensis, Tinocallis         caryaefoliae, Tomaspis spp., Toxoptera spp., Trialeurodes         vaporariorum, Trioza spp., Typhlocyba spp., Unaspis spp., Viteus         vitifolii.     -   From the order of the Hymenoptera, for example, Diprion spp.,         Hoplocampa spp., Lasius spp., Monomorium pharaonis, Vespa spp.     -   From the order of the Isopoda, for example, Armadillidium         vulgare, Oniscus asellus, Por-cellio scaber.     -   From the order of the Isoptera, for example, Reticulitermes         spp., Odontotermes spp.     -   From the order of the Lepidoptera, for example, Acronicta major,         Aedia leucomelas, Agrotis spp., Alabama argillacea, Anticarsia         spp., Barathra brassicae, Bucculatrix thur-beriella, Bupalus         piniarius, Cacoecia podana, Capua reticulana, Carpocapsa         pomonella, Cheimatobia brumata, Chilo spp., Choristoneura         fumiferana, Clysia ambiguella, Cnaphalo-cerus spp., Earias         insulana, Ephestia kuehniella, Euproctis chrysorrhoea, Euxoa         spp., Feltia spp., Galleria mellonella, Helicoverpa spp.,         Heliothis spp., Hofmannophila pseudospretella, Homona magnanima,         Hyponomeuta padella, Laphygma spp., Lithocolletis blancardella,         Lithophane antennata, Loxagrotis albicosta, Lymantria spp.,         Malacosoma neustria, Mame-stra brassicae, Mocis repanda,         Mythimna separata, Oria spp., Oulema oryzae, Panolis flammea,         Pectinophora gossypiella, Phyllocnistis citrella, Pieris spp.,         Plutella xylostella, Prodenia spp., Pseudaletia spp.,         Pseudoplusia includens, Pyrausta nubilalis, Spodoptera spp.,         Thermesia gemmatalis, Tinea pellionella, Tineola bisselliella,         Tortrix viridana, Trichoplusia spp.     -   From the order of the Orthoptera, for example, Acheta         domesticus, Blatta orientalis, Blattella germanica, Gryllotalpa         spp., Leucophaea maderae, Locusta spp., Melanoplus spp.,         Periplaneta americana, Schistocerca gregaria.     -   From the order of the Siphonaptera, for example, Ceratophyllus         spp., Xenopsylla cheopis.     -   From the order of the Symphyla, for example, Scutigerella         immaculata.     -   From the order of the Thysanoptera, for example, Baliothrips         biformis, Enneothrips flavens, Frankliniella spp., Heliothrips         spp., Hercinothrips femoralis, Kakothrips spp., Rhipiphorothrips         cruentatus, Scirtothrips spp., Taeniothrips cardamoni, Thrips         spp.     -   From the order of the Thysanura, for example, Lepisma         saccharina.     -   The phytoparasitic nematodes include, for example, Anguina spp.,         Aphelenchoides spp., Belonoaimus spp., Bursaphelenchus spp.,         Ditylenchus dipsaci, Globodera spp., Heliocotylenchus spp.,         Heterodera spp., Longidorus spp., Meloidogyne spp., Pratylenchus         spp., Radopholus similis, Rotylenchus spp., Trichodorus spp.,         Tylenchorhynchus spp., Tylenchulus spp., Tylenchulus         semipenetrans, Xiphinema spp.

The method according to the invention for the treatment of Bt vegetables, Bt maize, Bt cotton, Bt soya beans, Bt tobacco and also Bt rice, Bt sugar beets or Bt potatoes is particularly suitable for controlling aphids (Aphidina), whiteflies (Trialeurodes), thrips (Thysanoptera), spider mites (Arachnida), soft scale insects or mealy bugs (Coccoidae and Pseudococcoidae, respectively).

The active compounds which can be used according to the invention can be employed in customary formulations, such as solutions, emulsions, wettable powders, water- and oil-based suspensions, powders, dusts, pastes, soluble powders, soluble granules, granules for broadcasting, suspoemulsion concentrates, natural compounds impregnated with active compound, synthetic substances impregnated with active compound, fertilizers and also microencapsulations in polymeric substances.

These formulations are prepared in a known manner, for example by mixing the active compounds with extenders, i.e. liquid solvents and/or solid carriers, if appropriate using surfactants, i.e. emulsifiers and/or dispersants and/or foam-formers. The formulations are prepared either in suitable plants or else before or during application.

Wettable powders are preparations which can be dispersed homogeneously in water and which, in addition to the active compound and beside a diluent or inert substance, also comprise wetting agents, for example polyethoxylated alkylphenols, polyethoxylated fatty alcohols, alkylsulphonates or alkylphenylsulphonates and dispersants, for example sodium lignosulphonate, sodium 2,2′-dinaphthylmethane-6,6′-disulphonate.

Dusts are obtained by grinding the active compound with finely distributed solid substances, for example talc, natural clays, such as kaolin, bentonite, pyrophillite or diatomaceous earth. Granules can be prepared either by spraying the active compound onto granular inert material capable of adsorption or by applying active compound concentrates to the surface of carrier substances, such as sand, kaolinites or granular inert material, by means of adhesives, for example polyvinyl alcohol, sodium polyacrylate or mineral oils. Suitable active compounds can also be granulated in the manner customary for the preparation of fertilizer granules—if desired as a mixture with fertilizers.

Suitable for use as auxiliaries are substances which are suitable for imparting to the composition itself and/or to preparations derived therefrom (for example spray liquors, seed dressings) particular properties such as certain technical properties and/or also particular biological properties. Typical suitable auxiliaries are: extenders, solvents and carriers.

Suitable extenders are, for example, water, polar and nonpolar organic chemical liquids, for example from the classes of the aromatic and non-aromatic hydrocarbons (such as paraffins, alkylbenzenes, alkylnaphthalenes, chlorobenzenes), the alcohols and polyols (which, if appropriate, may also be substituted, etherified and/or esterified), the ketones (such as acetone, cyclohexanone), esters (including fats and oils) and (poly)ethers, the unsubstituted and substituted amines, amides, lactams (such as N-alkylpyrrolidones) and lactones, the sulphones and sulphoxides (such as dimethyl sulphoxide).

If the extender used is water, it is also possible to employ, for example, organic solvents as auxiliary solvents. Essentially, suitable liquid solvents are: aromatics such as xylene, toluene or alkylnaphthalenes, chlorinated aromatics and chlorinated aliphatic hydrocarbons such as chlorobenzenes, chloroethylenes or methylene chloride, aliphatic hydrocarbons such as cyclohexane or paraffins, for example petroleum fractions, mineral and vegetable oils, alcohols such as butanol or glycol and also their ethers and esters, ketones such as acetone, methyl ethyl ketone, methyl isobutyl ketone or cyclohexanone, strongly polar solvents such as dimethyl sulphoxide, and also water.

Suitable solid carriers are for example, ammonium salts and ground natural minerals such as kaolins, clays, talc, chalk, quartz, attapulgite, montmorillonite or diatomaceous earth, and ground synthetic minerals, such as finely divided silica, alumina and silicates; suitable solid carriers for granules are: for example, crushed and fractionated natural rocks such as calcite, marble, pumice, sepiolite and dolomite, and also synthetic granules of inorganic and organic meals, and granules of organic material such as paper, sawdust, coconut shells, maize cobs and tobacco stalks; suitable emulsifiers and/or foam-formers are: for example, nonionic and anionic emulsifiers, such as polyoxyethylene fatty acid esters, polyoxyethylene fatty alcohol ethers, for example alkylaryl polyglycol ethers, alkylsulphonates, alkyl sulphates, arylsulphonates and also protein hydrolysates; suitable dispersants are nonionic and/or ionic substances, for example from the classes of the alcohol-POE and/or -POP ethers, acid and/or POP POE esters, alkylaryl and/or POP POE ethers, fat and/or POP POE adducts, POE- and/or POP-polyol derivatives, POE- and/or POP-sorbitan or -sugar adducts, alkyl or aryl sulphates, alkyl- or arylsulphonates and alkyl or aryl phosphates or the corresponding PO-ether adducts. Furthermore, suitable oligo- or polymers, for example those derived from vinylic monomers, from acrylic acid, from EO and/or PO alone or in combination with, for example, (poly)alcohols or (poly)amines. It is also possible to employ lignin and its sulphonic acid derivatives, unmodified and modified celluloses, aromatic and/or aliphatic sulphonic acids and their adducts with formaldehyde.

Tackifiers such as carboxymethylcellulose and natural and synthetic polymers in the form of powders, granules or lattices, such as gum arabic, polyvinyl alcohol and polyvinyl acetate, as well as natural phospholipids such as cephalins and lecithins, and synthetic phospholipids, can be used in the formulations.

It is possible to use colorants such as inorganic pigments, for example iron oxide, titanium oxide and Prussian Blue, and organic dyestuffs, such as alizarin dyestuffs, azo dyestuffs and metal phthalocyanine dyestuffs, and trace nutrients such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Other possible additives are perfumes, mineral or vegetable, optionally modified oils, waxes and nutrients (including trace nutrients), such as salts of iron, manganese, boron, copper, cobalt, molybdenum and zinc.

Stabilizers, such as low-temperature stabilizers, preservatives, antioxidants, light stabilizers or other agents which improve chemical and/or physical stability may also be present.

These individual types of formulation are known in principle and are described, for example, in: “Pesticides Formulations”, 2nd Ed., Marcel Dekker N.Y.; Martens, 1979, “Spray Drying Handbook”, 3rd Ed., G. Goodwin Ltd. London.

Based on his general expert knowledge, the person skilled in the art is able to choose suitable formulation auxiliaries (in this context, see, for example, Watkins, “Handbook of Insecticide Dust Diluents and Carriers”, 2nd Ed., Darland Books, Caldwell N.J.).

In a preferred embodiment, the plants or plant parts are treated according to the invention with an oil-based suspension concentrate. An advantageous suspension concentrate is known from WO 2005/084435 (EP 1 725 104 A2). It consists of at least one room-temperature-solid active agrochemical substance, at least one “closed” penetrant, at least one vegetable oil or mineral oil, at least one nonionic surfactant and/or at least one anionic surfactant, and optionally one or more additives from the groups of the emulsifiers, foam inhibitors, preservatives, antioxidants, colorants and/or inert filler materials. Preferred embodiments of the suspension concentrate are described in the above-mentioned WO 2005/084435. For the purpose of the disclosure, both documents are incorporated herein in their entirety by way of reference.

In a further preferred embodiment, the plants or plant parts are treated according to the invention with compositions comprising ammonium or phosphonium salts and, if appropriate, penetrants. Advantageous compositions are known from WO2007/068355 and from the not prior-published EP 07109732.3. They consist of at least one compound of the formula (I) and at least one ammonium or phosphonium salt and, if appropriate, penetrants. Preferred embodiments are described in WO2007/068355 and the not prior-published EP 07109732.3. For the purpose of the disclosure, these documents are incorporated herein in their entirety by way of reference.

In general, the formulations comprise from 0.01 to 98% by weight of active compound, preferably from 0.5 to 90%. In wettable powders, the active compound concentration is, for example, from about 10 to 90% by weight, the remainder to 100% by weight consisting of customary formulation components. In the case of emulsifiable concentrates, the active compound concentration can be from about 5 to 80% by weight. In most cases, formulations in the form of dusts comprise from 5 to 20% by weight of active compound, sprayable solutions comprise about 2 to 20% by weight. In the case of granules, the active compound content depends partially on whether the active compound is present in liquid or solid form and on which granulation auxiliaries, fillers, etc., are used.

The required application rate may also vary with external conditions such as, inter alia, temperature and humidity. It may vary within wide limits, for example between 0.1 g/h and 5.0 kg/ha or more of active substance. However, they are preferably between 0.1 g/ha and 1.0 kg/ha. Owing to the synergistic effects between Bt vegetables and the insecticide, particular preference is given to application rates of from 0.1 to 500 g/ha.

For compounds of the formula (I), preference is given to application rates of from 10 to 500 g/ha; particularly preferred are from 10 to 200 g/ha.

In a particular embodiment of the method according to the invention, the compound of the formula (I) is employed in an application rate of from 0.1 g/ha to 5.0 kg/ha, preferably from 0.1 to 500 g/ha and particularly preferably from 50 to 500 g/ha and especially preferably from 50 to 200 g/ha.

In their commercial formulations and in the use forms prepared from these formulations, the active compounds according to the invention may be present as mixtures with other active compounds, such as insecticides, attractants, sterilants, acaricides, nematicides, fungicides, growth-regulating substances or herbicides.

A mixture with other known compounds, such as herbicides, fertilizers, growth regulators, safeners, semiochemicals, or else with agents for improving plant properties is also possible.

The active compound content of the use forms prepared from the commercial formulations can be from 0.00000001 to 95% by weight, preferably between 0.00001 and 1% by weight, of active compound.

Example Compound (1-5) on Transgenic Bt-Plant Spodoptera frugiperda—Spray Application on Transgenic Soy Bean, Field Trial

For preparing the stock solution, 20 mg of active compound is solved in 200 μl of dimethylformamide and filled-up with 9.78 ml SC blank formulation of Belt. The final test concentrations are prepared by dilution with water.

The test is conducted with conventional soybean plants (Glycine max; non-transgenic) and transgenic soybean plants containing a Cry1Ac gene (Intacta from Monsanto). When the plants are in stage V2 (3 nodes with 2 unfolded trifoliolates), they are treated by spray application with the active compound preparation. After application, clip-cages with 5-6 L2 larvae of the fall army worm (Spodoptera frugiperda) are placed on the leaves.

After the specified period of time, feeding damage (white holes on leaves) of Spodoptera frugiperda on conventional soybean, FIG. 1 a, in comparison to Intacta soybean, FIG. 1 b, is visualized on 3 randomly picked soybean leaves out of 5 replicate plots (R₁-R₅).

According to the present application in this test the following combinations of transgenic plant and compound shows a superior effect compared to the treated, non-transgenic plant respectively the non-treated, transgenic plant:

TABLE A 3 days after application (3 DAA) Infection 1 + 3 days (Inf 1 + 3) 5 replicates per variety Compound Conc. [g ai/ha] Soy variety 1 Untreated control Conventional 2 Untreated control Intacta 9 Compound (I-5) 12 Conventional 10 Compound (I-5) 24 Conventional 11 Compound (I-5) 36 Conventional 12 Compound (I-5) 12 Intacta 13 Compound (I-5) 24 Intacta 14 Compound (I-5) 36 Intacta 15 SC blank formulation  0 Conventional 16 SC blank formulation  0 Intacta 17 Water  0 Conventional 18 Water  0 Intacta Results of the experiments 1, 2 and 9 to 18 of Table A are shown in FIGS. 1 a and 1 b 

1. Method for improving utilization of production potential of a transgenic plant and/or for controlling/combating/treating insect and/or nematode pests, comprising treating the plant with an effective amount of at least one compound of formula (I)

wherein A represents individually halogen, cyano, nitro, hydroxyl, amino, C₁-C₈ alkyl group, substituted C₁-C₈ alkyl group having at least one substituent elected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group, C₁-C₃ alkylthio group, halo C₁-C₃ alkylthio group, C₁-C₃ alkylsulfinyl group, halo C₁-C₃ alkylsulfinyl group, C₁-C₃ alkylsulfonyl group, halo C₁-C₃ alkylsulfonyl group and C₁-C₃ alkylthio, C₁-C₃ alkyl group; further, an arbitrary saturated carbon atom in said optionally substituted C₁-C₈ alkyl group; n represents 0, 1, 2, 3 or 4, optionally 0, 1 or 2; R₁ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₂ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₃ represents O or S; R₄ represents O or S; Y represents individually hydrogen, halogen, cyano, nitro, C₁-C₆ alkyl group, halo C₁-C₆ alkyl group, C₂-C₆ alkenyl group, halo C₂-C₆ alkenyl group, C₂-C₆ alkynyl group, halo C₂-C₆ alkynyl group, C₃-C₆ cycloalkyl group, halo C₃-C₆ cycloalkyl group, C₁-C₆ alkoxy group, halo C₁-C₆ alkoxy group, C₁-C₆ alkylthio group, halo C₁-C₆ alkylthio group, C₁-C₆ alkylsulfinyl group, halo C₁-C₆ alkylsulfinyl group, C₁-C₆ alkylsulfonyl group, or halo C₁-C₆ alkylsulfonyl group; m represents 0, 1, 2, 3, or 4; X represents a C₁-C₈ alkyl group or a substituted C₁-C₈ alkyl group having at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group.
 2. Method according to claim 1, wherein the compound of formula (I) is formula (I-1):

wherein Hal represents F, Cl, I or Br; and X′ represents C₁-C₆ alkyl or substituted C₁-C₆ alkyl having at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, optionally a C₁-C₆ cyanoalkyl; A′ represents C₁-C₃ alkyl, C₁-C₃ haloalkyl, halogen, optionally methyl, halomethyl, ethyl or haloethyl, optionally methyl or ethyl; n represents 0, 1, 2, 3 or 4, optionally 0, 1 or 2, optionally
 1. 3. Method according to claim 1, wherein the compound of the formula (I) is selected from the group consisting of compound (I-2), (I-3), (I-4) or (I-5):


4. Method according to claim 3, wherein the compound of formula (I) is compound (I-5).
 5. Method according to claim 1, wherein the transgenic plant contains at least one cry-gene or a cry-gene fragment coding for a Bt toxin.
 6. Method according to claim 5, wherein the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the subgroup cry1A.
 7. Method according to claim 6, wherein the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the subgroups cry1Aa, cry1Ab and cry1Ac or a hybrid thereof.
 8. Method according to claim 5, wherein the Bt toxin is encoded by a bt-gene or fragment thereof comprising event MON87701.
 9. Method according to claim 1, wherein the transgenic plant is a vegetable plant, maize plant, soya bean plant, cotton plant, tobacco plant, rice plant, sugar beet plant, oilseed rape plant or potato plant.
 10. Method according to claim 1, wherein the compound of formula (I) is present in a mixture with at least one mixing partner.
 11. Synergistic composition comprising a Bt toxin, optionally a Bt toxin encoded by a bt-gene or fragment thereof comprising event MON87701, and a compound of formula (I)

wherein A represents individually halogen, cyano, nitro, hydroxyl, amino, C₁-C₈ alkyl group, substituted C₁-C₈ alkyl group having at least one substituent elected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group, C₁-C₃ alkylthio group, halo C₁-C₃ alkylthio group, C₁-C₃ alkylsulfinyl group, halo C₁-C₃ alkylsulfinyl group, C₁-C₃ alkylsulfonyl group, halo C₁-C₃ alkylsulfonyl group and C₁-C₃ alkylthio, C₁-C₃ alkyl group; further, an arbitrary saturated carbon atom in said optionally substituted C₁-C₈ alkyl group; n represents 0, 1, 2, 3 or 4, optionally 0, 1 or 2; R₁ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₂ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₃ represents O or S; R₄ represents O or S; Y represents individually hydrogen, halogen, cyano, nitro, C₁-C₆ alkyl group, halo C₁-C₆ alkyl group, C₂-C₆ alkenyl group, halo C₂-C₆ alkenyl group, C₂-C₆ alkynyl group, halo C₂-C₆ alkynyl group, C₃-C₆ cycloalkyl group, halo C₃-C₆ cycloalkyl group, C₁-C₆ alkoxy group, halo C₁-C₆ alkoxy group, C₁-C₆ alkylthio group, halo C₁-C₆ alkylthio group, C₁-C₆ alkylsulfinyl group, halo C₁-C₆ alkylsulfinyl group, C₁-C₆ alkylsulfonyl group, or halo C₁-C₆ alkylsulfonyl group; m represents 0, 1, 2, 3, or 4; X represents a C₁-C₈ alkyl group or a substituted C₁-C₈ alkyl group having at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group.
 12. Synergistic composition according to claim 11, wherein the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the group consisting of cry1, cry2, cry3, cry5 and cry9, optionally cry1.
 13. Synergistic composition according to claim 12, wherein the Bt toxin is encoded by a cry gene or a cry-gene fragment selected from the subgroup cry1A, optionally cry1Aa, cry1Ab and cry1Ac.
 14. Synergistic composition according to claim 13, wherein the Bt toxin is encoded by a bt-gene or fragment thereof comprising event MON87701.
 15. A Bt plant, wherein at least 0.00001 g of a compound of formula (I),

wherein A represents individually halogen, cyano, nitro, hydroxyl, amino, C₁-C₈ alkyl group, substituted C₁-C₈ alkyl group having at least one substituent elected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group, C₁-C₃ alkylthio group, halo C₁-C₃ alkylthio group, C₁-C₃ alkylsulfinyl group, halo C₁-C₃ alkylsulfinyl group, C₁-C₃ alkylsulfonyl group, halo C₁-C₃ alkylsulfonyl group and C₁-C₃ alkylthio, C₁-C₃ alkyl group; further, an arbitrary saturated carbon atom in said optionally substituted C₁-C₈ alkyl group; n represents 0, 1, 2, 3 or 4, optionally 0, 1 or 2; R₁ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₂ represents hydrogen, halogen, cyano C₁-C₈ alkyl or C₁-C₈ haloalkyl; R₃ represents O or S; R₄ represents O or S; Y represents individually hydrogen, halogen, cyano, nitro, C₁-C₆ alkyl group, halo C₁-C₆ alkyl group, C₂-C₆ alkenyl group, halo C₂-C₆ alkenyl group, C₂-C₆ alkynyl group, halo C₂-C₆ alkynyl group, C₃-C₆ cycloalkyl group, halo C₃-C₆ cycloalkyl group, C₁-C₆ alkoxy group, halo C₁-C₆ alkoxy group, C₁-C₆ alkylthio group, halo C₁-C₆ alkylthio group, C₁-C₆ alkylsulfinyl group, halo C₁-C₆ alkylsulfinyl group, C₁-C₆ alkylsulfonyl group, or halo C₁-C₆ alkylsulfonyl group; m represents 0, 1, 2, 3, or 4; X represents a C₁-C₈ alkyl group or a substituted C₁-C₈ alkyl group having at least one substituent selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, halo C₁-C₃ alkyl group, C₁-C₃ alkoxy group, halo C₁-C₃ alkoxy group optionally compound (I-5),

is attached to said plant. 